• @About this App Makindo
  • @Contributers
  • @Developer and Author
  • @Join Team Makindo
  • @Makindo Questions
  • @Privacy and Data Policy
  • ACTH (Adrenocorticotropic hormone)
  • AF and Anticoagulation ✅
  • AFP (Alpha-fetoprotein) Testing
  • AIDS (HIV) Neurological Disease
  • AIDS (HIV) Respiratory disease
  • AIDS Dementia Complex (HIV) ✅
  • AIDS HAART Antiretroviral Drugs ✅
  • AIDS HIV Infection and a Fever ✅
  • AIDS(HIV) Gastrointestinal Disease ✅
  • APGAR Scoring (Children)
  • APTT and Coagulation
  • Abacavir 💊
  • Abatacept 💊
  • Abbey Pain Scale
  • Abbreviated Mental Test Score (AMTS)
  • Abciximab 💊
  • Abdominal Aortic Aneurysm (AAA) ✅
  • Abdominal Distension
  • Abdominal Mass (Child health)
  • Abdominal Masses: Clinical Approach and Considerations
  • Abdominal X Ray Collections
  • Abdominal X-Ray (AXR)
  • Abdominal paracentesis for ascites
  • Abducent Nerve (Cranial Nerve VI)
  • Abetalipoproteinemia (Bassen-Kornzweig Syndrome)
  • Abnormal Involuntary Movements
  • Abnormal eating exercising behaviour (Children)
  • Abnormal urinalysis
  • Abscess - General
  • Absence Seizure
  • Acamprosate 💊
  • Acanthocytes
  • Acanthosis Nigricans
  • Acarbose 💊
  • Accelerated Idioventricular Rhythm ❤️
  • Accessory Nerve (Cranial Nerve XI)
  • Acetazolamide 💊
  • Acetylcholine Receptor Antibodies
  • Acetylcholinesterase inhibitors
  • Achalasia
  • Achenbach’s syndrome
  • Achilles Tendon rupture
  • Achondroplasia ✅
  • Aciclovir 💊
  • Acid maltase deficiency (Pompe disease)
  • Acid-Base abnorrmalities
  • Acne Vulgaris ✅
  • Acoustic Neuroma ✅
  • Acquired Long QT syndrome (LQTS)
  • Acrodermatitis enteropathica (Children)
  • Acromegaly and Giantism ✅
  • Acromio-clavicular joint
  • Actinic Keratosis
  • Actinomyces israeli
  • Action Potential Neuron Versus Cardiac Ventricular Myocyte
  • Activated Charcoal
  • Active Proctitis ✅
  • Actrapid (Insulin) 💊
  • Acute (Ascending) Cholangitis ✅
  • Acute Abdomen - Perforation of a Viscus
  • Acute Abdominal Pain (OSCE focused)
  • Acute Abdominal Pain - Children ✅
  • Acute Abdominal Pain in Adults
  • Acute Acalculous Cholecystitis✅
  • Acute Airway Obstruction
  • Acute Anaphylactoid Reactions
  • Acute Anaphylaxis ✅
  • Acute Appendicitis (OSCE focused)
  • Acute Appendicitis in Children ✅
  • Acute Appendicitis ✅
  • Acute Bacterial Meningitis (Adults) ✅
  • Acute Bacterial Meningitis in Children ✅
  • Acute Bacterial Prostatitis ✅
  • Acute Blepharitis 👁️
  • Acute Bronchitis ✅
  • Acute Cardiogenic Pulmonary Oedema (CPO/LVF) ❤️
  • Acute Change in Vision or Vision Loss (OSCE focused)
  • Acute Chest Syndrome (Sickle Cell) ✅
  • Acute Cholecystitis ✅
  • Acute Colonic Pseudo-obstruction
  • Acute Compartment Syndrome
  • Acute Coronary Syndrome (ACS) NSTEMI USA ❤️ ✅
  • Acute Coronary Syndrome (ACS) STEMI ❤️ ✅
  • Acute Coronary Syndrome (ACS): Chest Pain ❤️ ✅
  • Acute Coronary Syndrome (ACS): Complications
  • Acute Coronary Syndrome Grace score ❤️
  • Acute Coronary Syndrome TIMI Score
  • Acute Coronary Syndrome: Cardiac Thrombolysis ❤️
  • Acute Coronary Syndrome: LBBB and AMI
  • Acute Coronary Syndrome: Overview
  • Acute Coronary Syndrome: Unstable Angina
  • Acute Coronary: Percutaneous Coronary Intervention
  • Acute Delirium
  • Acute Disc Prolapse
  • Acute Disseminated Encephalomyelitis
  • Acute Dystonic Reaction
  • Acute Encephalitis ✅
  • Acute Eosinophilic Pneumonia
  • Acute Epiglottitis
  • Acute Exacerbation of COPD✅
  • Acute Fatty Liver of Pregnancy
  • Acute Glaucoma
  • Acute Glomerulonephritis in Children ✅
  • Acute Hepatic Porphyrias ✅
  • Acute Hepatitis and Acute Liver disease
  • Acute Hydrocephalus
  • Acute Hypotension ✅
  • Acute Inflammation
  • Acute Intermittent Porphyria (AIP)
  • Acute Interstitial nephritis
  • Acute Joint Pain and Swelling (Children)
  • Acute Kidney Injury ✅
  • Acute Limb Ischaemia
  • Acute Liver Disease & Acute Liver Failure ✅
  • Acute Lymphangitis
  • Acute Lymphoblastic Leukaemia (ALL) ✅
  • Acute Monoarthritis
  • Acute Myeloblastic Leukaemia (AML) ✅
  • Acute Myocarditis ✅
  • Acute Neck Injury (no fracture)
  • Acute Necrotizing Ulcerative Gingivitis
  • Acute Pancreatitis ✅
  • Acute Pericarditis ✅
  • Acute Phase reactants
  • Acute Promyelocytic Leukaemia (APML)
  • Acute Psychosis / Agitation
  • Acute Pyelonephritis and Urosepsis (UTI) ✅
  • Acute Radiation Syndromes
  • Acute Renal / Ureteric Colic and Urinary Tract Stones ✅
  • Acute Respiratory Distress Syndrome (ARDS)✅
  • Acute Retroviral Syndrome (HIV)
  • Acute Rhabdomyolysis ✅
  • Acute Right-Sided Weakness (OSCE focused) 🧠
  • Acute Rotator Cuff Tear ✅
  • Acute Severe Asthma (Status Asthmaticus)✅
  • Acute Severe Colitis
  • Acute Stroke Care Guidance UK Ireland 2023
  • Acute Tracheitis
  • Acute Urinary Retention
  • Acute Uterine Haemorrhage ✅
  • Acute and Chronic Diarrhoea ✅
  • Acute and Chronic Gout ✅
  • Acute on Chronic Liver Disease Decompensation
  • Acute rash (Child Health)
  • Acutely Ill Critical care patient with High NEWS
  • Acutely Ill Patient with Parkinson's disease
  • Adalimumab 💊
  • Addenbrooke's Cognitive Examination-Revised (ACER)
  • Addison Disease (Adrenal Insufficiency)
  • Adefovir 💊
  • Adenocarcinoma of the Ampulla of vater
  • Adenosine deaminase deficiency
  • Adenosine 💊
  • Adhesive Capsulitis (Frozen Shoulder) ✅
  • Administer IV Injection
  • Adrenal Adenomas
  • Adrenal Cancer
  • Adrenal Masses Incidentalomas
  • Adrenal crises (Paediatric) ✅
  • Adrenaline (Epinephrine) 💊
  • Adrenoleukodystrophy
  • Adrenomyeloneuropathy
  • Adult Hypertension ✅
  • Adult Onset Stills Disease
  • Adult Polycystic kidney disease ✅
  • Adverse Drug Effects
  • African Trypanosomiasis (Sleeping sickness)
  • Age-Related Macular Degeneration (ARMD)
  • Aicardi syndrome
  • Air Embolism ✅
  • Alberta Stroke program Early CT score (ASPECT) scoring system
  • Albumin
  • Albumin-Protein Creatinine Ratio (PCR)
  • Alcohol Metabolism
  • Alcohol Withdrawal (Delirium Tremens)
  • Alcoholic Hepatitis
  • Alcoholic Ketoacidosis
  • Aldosterone
  • Alendronate (Alendronic acid) 💊
  • Alfacalcidol 💊
  • Algorithms
  • Alkaline phosphatase (ALP)
  • Alkalinisation of urine
  • Alkaptonuria
  • Allergic Bronchopulmonary Aspergillosis
  • Allergic Rhinitis
  • Allergic disorders
  • Allergies
  • Allogeneic stem cell transplantation
  • Allopurinol 💊
  • Alogliptin (Vipidia) 💊
  • Alopecia Areata
  • Alopecia ✅
  • Alpha Thalassaemia ✅
  • Alpha subunit (ASU) of TSH
  • Alpha-1 Antitrypsin (AAT) deficiency
  • Alpha-gal syndrome
  • Alport's Syndrome
  • Alteplase 💊
  • Altitude sickness / Acute Mountain sickness
  • Aluminium and Magnesium Antacids
  • Alveolar Gas Equation
  • Alzheimer disease (Dementia) ✅
  • Amantadine 💊
  • Amaurosis fugax
  • Amblyopia 👁️
  • Ameloblastoma
  • Amenorrhoea
  • American Trypanosomiasis (Chagas Disease)
  • Amiloride
  • Amino acids
  • Aminoglycosides 💊
  • Aminophylline 💊
  • Aminosalicylates 💊
  • Amiodarone and Thyroid disease
  • Amiodarone 💊
  • Amitriptyline 💊
  • Amlodipine 💊
  • Ammonia Encephalopathy
  • Amnestic syndromes and Memory Disorders
  • Amoebiasis Amoebic (Entamoeba histolytica)
  • Amoxicillin 💊
  • Amphetamine toxicity⚠️
  • Amphotericin B 💊
  • Ampicillin 💊
  • Amputations
  • Anaemia (Child Health)
  • Anaemia (Pregnancy)
  • Anaemia in Chronic Kidney Disease
  • Anaemia of Chronic Disease ✅
  • Anaemia: Assessment ✅
  • Anaesthetics and Critical Care Revision Guide ✅
  • Anagrelide 💊
  • Anakinra 💊
  • Anal Cancer ✅
  • Anal Fissure
  • Analgesic Nephropathy
  • Anaromy and Physiology of the Brain
  • Anatomy and Phsyiology of the Ear
  • Anatomy and Physiology of the Pituitary
  • Anatomy and Physiology of Cilia
  • Anatomy and Physiology of Female Genitalia and Reproduction
  • Anatomy and Physiology of Male Genitalia
  • Anatomy and Physiology of Nerves
  • Anatomy and Physiology of Ribs and Chest Wall
  • Anatomy and Physiology of Small Bowel
  • Anatomy and Physiology of the Abdomen
  • Anatomy and Physiology of the Adrenal Gland
  • Anatomy and Physiology of the Basal Ganglia
  • Anatomy and Physiology of the Biliary system
  • Anatomy and Physiology of the Bladder
  • Anatomy and Physiology of the Bone Marrow
  • Anatomy and Physiology of the Brainstem
  • Anatomy and Physiology of the Breast
  • Anatomy and Physiology of the Cauda equina
  • Anatomy and Physiology of the Cerebellum
  • Anatomy and Physiology of the Cerebral Cortex
  • Anatomy and Physiology of the Coronary Arteries
  • Anatomy and Physiology of the Diaphragm
  • Anatomy and Physiology of the Eye
  • Anatomy and Physiology of the Glomerulus
  • Anatomy and Physiology of the Heart
  • Anatomy and Physiology of the Kidneys
  • Anatomy and Physiology of the Large Bowel (Colon, Rectum, Anal Canal)
  • Anatomy and Physiology of the Larynx
  • Anatomy and Physiology of the Liver
  • Anatomy and Physiology of the Lungs
  • Anatomy and Physiology of the Nose
  • Anatomy and Physiology of the Oesophagus
  • Anatomy and Physiology of the Ovary
  • Anatomy and Physiology of the Pancreas
  • Anatomy and Physiology of the Parathyroid Gland
  • Anatomy and Physiology of the Pelvis
  • Anatomy and Physiology of the Pharynx
  • Anatomy and Physiology of the Rectum
  • Anatomy and Physiology of the Spinal Cord
  • Anatomy and Physiology of the Spine
  • Anatomy and Physiology of the Spleen
  • Anatomy and Physiology of the Stomach
  • Anatomy and Physiology of the Thorax
  • Anatomy and Physiology of the Thymus Gland
  • Anatomy and Physiology of the Thyroid Gland
  • Anatomy and Physiology of the Uterus and Fallopian Tubes
  • Anatomy and Physiology of the Vascular System
  • Anatomy and Physiology of the vagina
  • Anatomy and Physiology: Human
  • Anatomy of Cells and Physiology
  • Anatomy of Dentistry
  • Anatomy of the Hand
  • Anatomy of the Inguinal and Femoral canal
  • Anatomy of the Muscles
  • Anatomy of the Skin
  • Anatony and Physiology of the Nephron
  • Andexanet alfa
  • Androgen insensitivity syndrome
  • Aneurysms, ischaemic limb and occlusions
  • Angina bullosa haemorrhagica
  • Angiodysplasia
  • Angiomyolipoma
  • Angioneurotic Oedema
  • Angiotensin Converting Enzyme Inhibitors
  • Angiotensin Converting enzyme (ACE) 💊
  • Angular Stomatitis - Cheilitis
  • Anion Gap and Metabolic Acidosis
  • Ankle-Brachial Pressure Index (OSCE focused)
  • Ankylosing spondylitis
  • Anogenital Warts (HPV) ✅
  • Anomalous Coronary Arteries
  • Anorexia Nervosa
  • Anosmia
  • Antacid medication
  • Anterior / Medial Medullary Infarct (Dejerine Syndrome)
  • Anterior Choroidal Artery Ischaemic Stroke
  • Anterior Cruciate ligament injury
  • Anterior Horn Cell diseases
  • Anterior Spinal Cord syndrome
  • Anterior circulation Brain
  • Anthrax (Bacillus anthracis)
  • Anti microbial stewardship ✅
  • Anti-Citrullinated Protein Antibody (ACPA)
  • Anti-D immunoglobulin
  • Anti-Hu antibodies
  • Anti-NMDA (NMDAR) receptor encephalitis
  • Anti-OKT3 antibodies
  • Anti-RNP Antibody
  • Anti-Yo antibodies
  • Anti-neutrophilic cytoplasmic antibodies (ANCA)
  • Antiarrhythmic agents
  • Antibiotic Guidelines✅
  • Antibiotics Mechanisms
  • Antibiotics for Abdominal Infections
  • Anticholinergic Burden
  • Anticholinergic syndrome
  • Anticipation
  • Anticoagulation and Antithrombotic
  • Antidiuretic hormone (Vasopressin)
  • Antigen presenting cells
  • Antimicrobial Choices
  • Antimicrobial agents
  • Antimuscarinic drugs 💊
  • Antiphospholipid Syndrome
  • Antithrombin III deficiency (AT3)
  • Anuria and Oliguria
  • Anxiety Phobias and OCD
  • Anxiety disorder: generalised (GAD)
  • Aortic Dissection ✅
  • Aortic Regurgitation ✅
  • Aortic Sclerosis
  • Aortic Stenosis ✅
  • Aortoenteric fistula
  • Apathetic thyrotoxicosis
  • Apixaban 💊
  • Aplastic anaemia ✅
  • Apomorphine 💊
  • Apoptosis
  • Appendix Cancer Tumours
  • Approach to the Child with Respiratory Distress
  • Apraxia
  • Arachnoid cyst
  • Arnold Chiari malformation
  • Arrhythmias
  • Arrhythmogenic Right Ventricular Cardiomyopathy
  • Artemisinins 💊
  • Arterial blood gas sampling
  • Arterial thrombosis
  • Arteriovenous Malformations
  • Artery of Percheron stroke
  • Artery-to-artery embolic stroke
  • Artesunate
  • Arthritis Diagnosis Compared
  • Arthrocentesis and Synovial fluid analysis
  • Asbestos Related Lung disease
  • Ascites ✅
  • Aspergilloma
  • Aspergillus fumigatus
  • Aspirin 💊
  • Aspirin/Salicylate Toxicity
  • Assessing Hearing Loss
  • Assessing Significance
  • Assessing a Patient who is Shocked
  • Assessing and Painful Red eye
  • Assessment of Causes of Nausea 🤢
  • Assessment of causes of Vaginal Discharge
  • Asteatotic eczema
  • Asthma COPD overlap syndrome
  • Asthma✅
  • Astigmatism
  • Astrocytomas
  • Ataxia Telangiectasia
  • Atazanavir 💊
  • Atenolol 💊
  • Atherosclerosis ❤️
  • Atorvastatin 💊
  • Atracurium
  • Atrial Ectopic beats
  • Atrial Fibrillation and Rhythm Control ✅
  • Atrial Natriuretic Peptide (ANP)
  • Atrial myxoma ❤️
  • Atrial septal defect (ASD) ✅
  • Atrioventricular Block
  • Atrioventricular Nodal Reentrant Tachycardia AVNRT ❤️
  • Atrophic vaginitis
  • Atropine Sulfate 💊
  • Attention deficit hyperactivity disorder
  • Auditory hallucinations
  • Autism spectrum disorder
  • Autoimmune Haemolytic anaemia (AIHA) ✅
  • Autoimmune Hepatitis ✅
  • Autoimmune Liver Disease Table ✅
  • Autoimmune Polyendocrine Syndromes
  • Automatic Implantable Cardioverter Defibrillator (AICD)
  • Autonomic Nervous System
  • Autonomic neuropathy ✅
  • Autosomal Dominant
  • Autosomal Recessive
  • Avascular Necrosis of Femoral head
  • Axillary Nerve
  • Azathioprine 💊
  • Azithromycin 💊
  • B lymphocytes
  • BRASH syndrome
  • BRCA genes (Familial Breast Cancer)
  • Bacillary Dysentery
  • Bacillus cereus poisoning
  • Back pain ✅
  • Backpain / Backache
  • Baclofen 💊
  • Bacteria and their Infections
  • Bacterial Vaginosis
  • Bacteroides fragilis
  • Baker's (Popliteal) Cyst
  • Balanitis (Adults)
  • Balanitis (Children)
  • Balkan endemic nephropathy (BEN)
  • Balsalazide (Aminosalicylate) 💊
  • Barrett's oesophagus ✅
  • Barthel Index
  • Bartonella
  • Bartonella henselae (Cat Scratch Disease)
  • Bartters syndrome
  • Basal Cell Carcinoma (BCC) ✅
  • Basic Chemistry for Medicine
  • Basic Concepts of Pregnancy
  • Basic Neuroscience
  • Basic Neuroscience
  • Basic Physics for Medicine
  • Basic Statistics
  • Basics of Endocrinology
  • Basilar artery thrombosis
  • Bayes' Theorem
  • Becker Muscular dystrophy
  • Beclometasone (Beclomethasone) 💊
  • Beer Potomania
  • Behaviour/personality change ✅
  • Behavioural and Psychological (BPSD) Symptoms of Dementia
  • Behavioural difficulties in Adults ✅
  • Behavioural difficulties in childhood
  • Behcet's Syndrome
  • Bejel ( Treponema pallidum subspecies endemicum)
  • Belantamab mafodotin (Blenrep)
  • Bell's Palsy (Facial nerve palsy)
  • Bendroflumethiazide (Bendrofluazide) 💊
  • Benign Breast Disease
  • Benign Eyelid Conditions
  • Benign Paroxysmal Positional Vertigo (BPPV)
  • Benign Prostatic Hyperplasia✅
  • Benign recurrent intrahepatic cholestasis
  • Benzodiazepine Toxicity
  • Benzodiazepines
  • Benzylpenicillin Sodium (Penicillin G) 💊
  • Berg Balance Scale
  • Beriplex 💊
  • Berylliosis
  • Beta Agonists 💊
  • Beta Antagonists/Blockers
  • Beta Blocker toxicity⚠️
  • Beta Thalassaemia ✅
  • Beta-2 Microglobulin
  • Beta-lactamases 💊
  • Betahistine (Serc) 💊
  • Bezafibrate 💊
  • Bezafibrate 💊
  • Biceps tendon rupture
  • Bilateral Pontine Infarction due to Basilar Artery Thrombosis
  • Bile salt malabsorption (BAM)
  • Biliary atresia
  • Bilirubin
  • Biochemical Lab values
  • Biochemistry and Physiology of Globins
  • Biological Agents
  • Bioterrorism
  • Bipolar disorder: mania and hypomania ✅
  • Birt-Hogg-Dubé Syndrome
  • Bisacodyl 💊
  • Bisoprolol 💊
  • Bisphosphonates 💊
  • Bites and stings
  • Blackouts and faints (TLOC)
  • Bladder Cancer
  • Bladder Stones
  • Blank Templates
  • Bleeding Antepartum
  • Bleeding or High INR on Warfarin or other Anticoagulation
  • Bleomycin
  • Blindness - global causes
  • Blood
  • Blood Pressure
  • Blood Transfusion Reactions
  • Blood cultures
  • Blood film interpretation
  • Blood transfusion
  • Blotting Techniques: Gel Electrophoresis
  • Body Mass Index
  • Bone Pain
  • Bone Physiology
  • Bone disease Lab results
  • Bone metabolism RANK RANKL OPG pathway
  • Bone scintigraphy (Bone scan)
  • Bordetella pertussis (Whooping cough)
  • Borrelia burgdorferi
  • Borrelia recurrentis
  • Bortezomib
  • Botulism
  • Boxer's fracture
  • Brachial neuritis (neuralgic amyotrophy) Parsonage-Turner syndrome
  • Brain Abscess
  • Brain CT Collection
  • Brain Embryology
  • Brain Herniation syndromes
  • Brain MRI
  • Brain MRI Collection
  • Brain Metastases
  • Brain Natriuretic Peptide (BNP)
  • Brain Tumours in Children
  • Brain Tumours ✅
  • Branchial cleft cyst
  • Breaking Bad News (OSCE)
  • Breast Cancer ✅
  • Breast Cysts
  • Breast Lump Evaluation
  • Breast abscess and Mastitis and Fat Necrosis
  • Breast tenderness/pain
  • Breathlessness
  • Bretylium 💊
  • Brighton Mobility Score
  • Broad Complex Tachycardia
  • Bromocriptine 💊
  • Bronchial adenoma
  • Bronchiectasis
  • Bronchiolitis
  • Bronchoscopy
  • Brown-Sequard Spinal Cord syndrome
  • Brucella
  • Brucellosis
  • Brugada syndrome ✅
  • Bruising
  • Budd-Chiari syndrome ✅
  • Budesonide 💊
  • Buerger disease (Thromboangiitis obliterans) ✅
  • Bulbar vs Pseudobulbar palsy
  • Bulimia Nervosa
  • Bullous Pemphigoid ✅
  • Bumetanide
  • Bunions
  • Buprenorphine 💊
  • Bupropion 💊
  • Burkholderia cepacia
  • Burkitt's lymphoma
  • Burns Management Guide
  • Busulphan (Busulfan)
  • Byssinosis
  • C Programming
  • C# programming
  • C++ Programming
  • CADASIL
  • CARASIL
  • CNS fungal Infections
  • CNS infections
  • CSF Interpretation
  • CSF Rhinorrhoea
  • CT Basics for Stroke
  • CT Pulmonary angiogram (CTPA)
  • Cabergoline
  • Caesarean Section (CS)
  • Café-au-lait spots
  • Caisson Disease Decompression sickness (The Bends)
  • Calcific Uraemic Arteriolopathy (Calciphyalxis)
  • Calcitonin
  • Calcitriol (1,25 Dihydroxycholecalciferol) 💊
  • Calcium Channel Blockers
  • Calcium Chloride or Gluconate
  • Calcium Physiology
  • Calcium Pyrophosphate Deposition (Pseudogout)
  • Calcium Resonium
  • Calcium channel blockers toxicity⚠️
  • Calot's triangle
  • Campylobacter jejuni
  • Canaliculitis 👁️
  • Cancer Pathology
  • Cancer and Stroke
  • Cancer of Unknown Primary
  • Candesartan 💊
  • Candida Skin Infections ✅
  • Candidiasis
  • Cannabinoid Hyperemesis Syndrome (CHS)
  • Cannabis toxicity⚠️
  • Cannonball Metastases
  • Capacity in Older Adult
  • Capecitabine 💊
  • Caplacizumab 💊
  • Capnocytophaga canimorsus
  • Capnography
  • Capreomycin
  • Capsular and Pontine Warning Syndromes
  • Captopri 💊
  • Carbamazepine 💊
  • Carbapenemase-producing Enterobacteriaceae
  • Carbimazole 💊
  • Carbohydrates
  • Carbon Monoxide Toxicity
  • Carbon Tetrachloride Toxicity
  • Carbon dioxide embolism
  • Carcinoembryonic antigen (CEA)
  • Carcinoid Heart Disease ❤️
  • Carcinoid Tumour Syndrome
  • Carcinoma of the Bile Duct
  • Carcinoma of the Gallbladder ✅
  • Cardiac Amyloid heart disease
  • Cardiac Arrest in Pregnancy
  • Cardiac Catheter ablation
  • Cardiac Crib Sheets
  • Cardiac Echocardiography: Basics and Uses
  • Cardiac Electrophysiology and Arrhythmia management
  • Cardiac Embryology
  • Cardiac MRI ❤️
  • Cardiac Resynchronisation Therapy (CRT) Pacemaker
  • Cardiac Syndrome X (Microvascular Angina)
  • Cardiac Troponins
  • Cardiac Troponins
  • Cardiac and Respiratory Rehabilitation
  • Cardioembolic stroke
  • Cardiogenic shock
  • Cardiological Emergencies: Revision ✅
  • Cardiology Examination (OSCE)
  • Cardiology Investigations
  • Cardiology Revision Guide ✅
  • Cardiology: Cardiology Emergencies
  • Cardiology: Anatomy Physiology and Pharmacology
  • Cardiology: Heart Failure (Complete) ✅
  • Cardiology: History and Examination
  • Cardiology: Infective Endocardits
  • Cardiology: Ischaemic Heart Disease (ACS)
  • Cardiology: Pericardial Disease
  • Cardiology: Valvular heart disease
  • Cardiology: Venous Thromboembolism and Pulmonary Vascular Disease
  • Cardiology:Cardiac Arrhythmias
  • Cardiology:Cardiomyopathies
  • Cardiology:Congenital heart disease
  • Cardiology:Heart Failure
  • Cardiology:Hypertension, Blood Pressure and Prevention
  • Cardiopulmonary bypass
  • Cardiorenal Syndromes ✅
  • Cardiorespiratory Arrest
  • Caring for Patients with Dementia
  • Carmustine 💊
  • Caroticocavernous Fistula
  • Carotid Artery Dissection
  • Carotid Body Tumour
  • Carotid Endarterectomy ✅
  • Carotid Sinus Syncope
  • Carotid Web
  • Carotid sinus massage
  • Carpal tunnel syndrome
  • Carvedilol 💊
  • Caspases
  • Castleman's disease
  • Cataract
  • Catheter Related UTI
  • Catheter related Blood stream infection
  • Cauda Equina Syndrome (CES)
  • Caudate Nucleus
  • Causes of Eosinophila
  • Causes of Fatigue
  • Causes of Gradual Visual Loss over weeks and months
  • Causes of Ketoacidosis
  • Causes of Limp in Children
  • Causes of Neck Pain/Stiffness
  • Causes of Precious Puberty in Children
  • Causes of Ptosis
  • Causes of Short Stature in Children
  • Causes of Stroke
  • Causes of Tall Stature in Children
  • Causes of Tremor
  • Causes of Vertigo
  • Causes of a high Erythrocyte Sedimentation rate (ESR)
  • Causes of abnormal Vaginal bleeding
  • Causes of delayed Onset of Puberty in Children ✅
  • Causes of high C reactive protein (CRP)
  • Cavernous angiomas (Cavernomas)
  • Cavernous sinus
  • Cavernous sinus thrombosis
  • Cefaclor 💊
  • Cefalexin 💊
  • Cefotaxime 💊
  • Ceftazidime 💊
  • Ceftriaxone 💊
  • Cefuroxime 💊
  • Celecoxib 💊
  • Cell Adhesion Molecules
  • Cell Biology
  • Cell Cycle
  • Cell Response to Injury
  • Cellulitis and Erysipelas ✅
  • Central Pontine Myelinolysis (Osmotic Demyelination Syndrome) ✅
  • Central Retinal Arterial Occlusion (CRAO)
  • Central Spinal Cord Syndrome
  • Central Venous line Insertion
  • Central and Branch Retinal Vein Occlusion (CRVO/BRVO)
  • Centronuclear Myopathy (CNM)
  • Cerebellar Examination (OSCE)
  • Cerebellar Haemorrhage
  • Cerebellar Ischaemic Stroke
  • Cerebral Amyloid angiopathy (CAA) ✅
  • Cerebral Angiitis
  • Cerebral Angiography
  • Cerebral Angiography and Perfusion
  • Cerebral Arterial Perfusion and Clinical Correlates
  • Cerebral Atrophy vs Hydrocephalus
  • Cerebral Cortex
  • Cerebral Palsy & HIE
  • Cerebral Radiation Vasculopathy
  • Cerebral Salt Wasting
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  • Cerebral Veins 🧠
  • Cerebral Venous Thrombosis (CVT)
  • Cerebral arteritis
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  • Cervical Lymphadenopathy
  • Cervical Smear Results ✅
  • Cervical Spine Immobilisation and Management
  • Cervical cancer
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  • Cervical spondylosis
  • Cetirizine 💊
  • Chalazion
  • Chancroid
  • Change in Bowel habit
  • Change in stool colour
  • Charcot Foot Syndrome (CFS)
  • Charcot Marie Tooth (CMT) disease
  • Chediak Higashi syndrome
  • Chemical Pathology
  • Chemosis
  • Chemotherapeutic Agents
  • Chest Abdomen anatomy
  • Chest Pain
  • Chest Pain in the Emergency Department (OSCE focused) ❤️
  • Chest X Ray Collection
  • Chest X Ray Interpretation
  • Chest drain Insertion (Thoracostomy)
  • Chickenpox Varicella Infection ✅
  • Child Abuse and Safeguarding NHS
  • Child abuse
  • Child-Pugh Score: Child-Pugh Score: Cirrhosis Severity
  • Childhood Vaccination in the UK
  • Childhood Vaccination in the USA
  • Chlamydia Infections
  • Chlamydia psittaci
  • Chlamydia trachomatis
  • Chlamydophila pneumoniae
  • Chlorambucil
  • Chloramphenicol 💊
  • Chlordiazepoxide 💊
  • Chloroquine 💊
  • Chlorphenamine(Chlorpheniramine) 💊
  • Chlorpromazine 💊
  • Cholangiocarcinoma
  • Cholera (Vibrio cholera)
  • Cholestatic Jaundice
  • Cholesteatoma
  • Cholesterol - Lipids
  • Cholesterol Embolisation Syndrome
  • Cholinergic crisis-syndrome
  • Chondrocalcinosis
  • Chorea - Ballismus
  • Choreoacanthocytosis
  • Chorioamnionitis
  • Choriocarcinoma - Malignant Gestational Trophoblastic Disease
  • Chromatin
  • Chronic Bronchitis
  • Chronic Fatigue Syndrome 🧠
  • Chronic Glaucoma
  • Chronic Granulomatous Disease
  • Chronic Hepatitis
  • Chronic Inflammation
  • Chronic Inflammatory Demyelinating polyneuropathy
  • Chronic Interstitial Nephritis
  • Chronic Kidney Disease (CKD) ✅
  • Chronic Liver Disease ✅
  • Chronic Lymphocytic leukaemia (CLL) ✅
  • Chronic Myeloid Leukaemia (CML) ✅
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  • Chronic Visual Loss (OSCE focused)
  • Chronic abdominal pain
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  • Chronic joint pain/stiffness 🦴
  • Chronic mucocutaneous candidiasis
  • Ciclosporin 💊
  • Cimetidine 💊
  • Cinacalcet
  • Ciprofloxacin 💊
  • Circulatory Shock (Volume loss)
  • Cirrhosis
  • Cisatracurium
  • Cisplatin
  • Citalopram 💊
  • Cladribine
  • Clarithromycin 💊
  • Cleft lip or palate
  • Clindamycin 💊
  • Clinical Appearance Collections
  • Clinical Genetics Revision Guide ✅
  • Clinical History Pleuritic Chest Pain 🩺
  • Clinically Isolated Syndrome (CIS) – First Demyelinating Event
  • Clonidine 💊
  • Clopidogrel 💊
  • Clostridioides difficile Infection
  • Clostridium botulinum Infection
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  • Clotrimazole cream 💊
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  • Clozapine 💊
  • Clustered Regularly Interspaced Short Palindromic Repeats CRISPR
  • Co Careldopa (Sinemet)
  • Co-Beneldopa (Madopar)
  • Co-codamol 💊
  • Co-trimoxazole (Trimethoprim + Sulfamethoxazole) 💊
  • CoAmoxiclav (Augmentin) 💊
  • Coagulopathy
  • Coal Worker's Pneumoconiosis
  • Coarctation of the Aorta ✅
  • Cobalt Cardiomyopathy
  • Cocaine Toxicity and Chest pain
  • Cocaine abuse
  • Cocaine toxicity⚠️
  • Coccidioidomycosis
  • Codeine 💊
  • Coding
  • Coeliac disease ✅
  • Cogan Syndrome
  • Colchicine 💊
  • Cold Agglutinin Disease (CAD/AIHA)
  • Collagen
  • Colles’ fracture of the Radius
  • Colloid cyst in the third ventricle
  • Colloids vs Crystalloids
  • Coloboma
  • Colonic (Large bowel) Obstruction
  • Colonoscopy
  • Colorectal polyps ✅
  • Colorectal tumours ✅
  • Colposcopy
  • Comatose Patient (OSCE focused)
  • Combined Oral contraceptive pill (COCP) 💊
  • Common Chromosomal Defects
  • Common Genetic Disorders
  • Common Peroneal Nerve (CPN)
  • Common Problems in Elderly
  • Common Psychiatric Emergencies: Revision ✅
  • Common variable immunodeficiency
  • Commotio cordis
  • Community Acquired Pneumonia 🫁 ✅
  • Comparing Groups
  • Compilers
  • Complement
  • Components of a Eukaryotic Gene
  • Comprehensive Clinical Microbiology Tutorial for Medical Students
  • Comprehensive Geriatric Assessment (CGA)
  • Computer Networking
  • Computer Security
  • Concurrent Programming
  • Confirming Death
  • Confusion (OSCE focused)
  • Congenital Acyanotic Heart Disease
  • Congenital Adrenal hyperplasia
  • Congenital Complete Heart Block
  • Congenital Cyanotic Heart Disease (Children)
  • Congenital Hypothyroidism
  • Congenital Talipes Equinovarus - Clubfoot
  • Congenital abnormalities
  • Conjunctivitis
  • Consent ✅
  • Constipation (Adults) ✅
  • Constipation (Children)
  • Constipation in the Elderly
  • Constrictive Pericarditis ❤️
  • Contact Dermatitis
  • Continuous Ambulatory Peritoneal Dialysis (CAPD)
  • Continuous Positive Airways Pressure (CPAP) ✅
  • Contraception request/advice ✅
  • Conus Medullaris syndrome
  • Cor Pulmonale
  • Cord Prolapse
  • Corneal Abrasion
  • Coronary Interventions
  • Coronary artery bypass graft surgery ✅
  • Coronavirus SARS-CoV-2 (COVID-19) ✅
  • Corticobasal degeneration (Dementia)
  • Corticospinal Tract
  • Corticosteroid-related psychosis 💊
  • Corticosteroids : Uses and Cautions
  • Cotard's Syndrome
  • Cough (Adult)
  • Cough (Child)
  • Cowden Syndrome / PTEN Hamartoma Tumour Syndrome
  • Cowpox (Orthopoxvirus)
  • Coxiella Burnetii Q fever
  • Cramps
  • Craniopharyngioma
  • Creatinine Clearance
  • Creutzfeldt Jakob disease
  • Cri du Chat Syndrome
  • Crimean-Congo haemorrhagic fever
  • Critical Illness Neuromuscular Weakness (CINMW)
  • Critical care Crib Sheets
  • Crohn's disease ✅
  • Croup
  • Crouzon Syndrome
  • Crying baby 👶
  • Cryoprecipitate
  • Cryptococcus neoformans infections (Cryptococcal Infections)
  • Cryptogenic Organising Pneumonia (COP-BOOP)
  • Cryptogenic stroke
  • Cryptography
  • Cryptosporidiosis ✅
  • Crystal arthropathy
  • Cushing disease
  • Cushing syndrome
  • Cushing's Syndrome due to Ectopic ACTH
  • Cutaneous Larva Migrans
  • Cutaneous Warts
  • Cutaneous fungal infections
  • Cyanide toxicity⚠️
  • Cyanosis ❤️
  • Cyclical Vomiting Syndrome
  • Cyclizine
  • Cyclo-oxygenase (COX) enzymes
  • Cyclophosphamide 💊
  • Cycloserine
  • Cys leukotriene receptor antagonists 💊
  • Cystic Fibrosis ✅
  • Cystinosis
  • Cystinuria
  • Cystitis and Urethritis (UTI)
  • Cystoscopy
  • Cytokine Physiology
  • Cytomegalovirus (CMV) Retinitis ✅
  • Cytomegalovirus (CMV) infections
  • D Dimer
  • D-lactic acidosis or D-lactate encephalopathy
  • DNA and RNA
  • DNA replication
  • DNACPR in the Older Person
  • Dabigatran 💊
  • Dalteparin 💊
  • Dandy Walker syndrome
  • Dantrolene 💊
  • Dapagliflozin 💊
  • Darier’s disease (Keratosis Follicularis)
  • Darunavir 💊
  • Data Security and Protection
  • Data Structures
  • Data security awareness
  • Database Management
  • DeQuervain's thyroiditis
  • Death Certificates and Cremation UK
  • Death and dying
  • Decision Making by Clinicians
  • Decompressive Hemicraniectomy
  • Decreased appetite
  • Deep Vein Thrombosis (DVT) ✅
  • Deep brain stimulation
  • Dehydration (Child)
  • Dehydration Adult
  • Delusions
  • Demeclocycline 💊
  • Dementia with Lewy bodies
  • Dementias ✅
  • Demyelinating Diseases
  • Dengue Fever
  • Denosumab (Prolia) 💊
  • Dental Caries
  • Dentatorubral Pallidoluysian Atrophy (DRPLA)
  • Deprivation of Liberty Safeguards (DoLS) ✅
  • Dermatitis Herpetiformis
  • Dermatology Emergencies ✅
  • Dermatology Revision Guide ✅
  • Dermatology terms
  • Dermatomes
  • Dermatomyositis ✅
  • Dermoid cysts
  • Desferrioxamine 💊
  • Desmopressin (DDAVP) 💊
  • Desogestrel (Progestogen Only Pill) 💊
  • Developmental Delay & Abnormal Development in Children
  • Developmental Dislocation (Dysplasia) of the Hip (DDH)
  • Dexamethasone 💊
  • DiGeorge syndrome (22q11.2 deletion syndrome)
  • Diabetes Crib Sheets
  • Diabetes Insipidus (AVP Deficiency)
  • Diabetes Mellitus Type 1 and DKA (children)
  • Diabetes Mellitus Type 1 ✅
  • Diabetes Mellitus Type 2 ✅
  • Diabetes Mellitus Type 3C
  • Diabetes Variable Rate Insulin Infusion
  • Diabetes and Hypertension
  • Diabetes and Pregnancy
  • Diabetes in Children
  • Diabetes: (Autonomic) Neuropathy (DAN)
  • Diabetes: Basics ✅
  • Diabetes: Complications
  • Diabetes: Criteria US and UK
  • Diabetes: Eye Disease
  • Diabetes: Foot Problems
  • Diabetic Amyotrophy ✅
  • Diabetic Eye Disease
  • Diabetic Ketoacidosis (DKA) Adults ✅
  • Diabetic Ketoacidosis (DKA) Children
  • Diabetic nephropathy
  • Diabetic neuropathy
  • Diamond-Blackfan anaemia
  • Diamorphine 💊
  • Diaphragmatic disorders
  • Diarrhoea (Children)
  • Diazepam 💊
  • Didanosine (ddI) 💊
  • Diethylstilbestrol
  • Dieulafoy Lesion
  • Different Forms of Medical Trials and Studies
  • Differential Diagnosis of Malar Rash
  • Differentials of ABC
  • Differentials of Painful thigh
  • Differentiation syndrome
  • Difficulty Swallowing (Dysphagia)
  • Difficulty with breastfeeding
  • Diffuse Alveolar Haemorrhage (DAH)
  • Diffuse Oesophageal spasm
  • Diffuse Parenchymal Lung Disease (DPLD) or Interstitial Lung Disease (ILD)
  • Diffuse large B-cell lymphoma
  • Diffusion Capacity
  • Digoxin Toxicity⚠️
  • Digoxin 💊
  • Digoxin-specific antibody ✅
  • Dihydrocodeine 💊
  • Dilated Cardiomyopathy ✅
  • Diltiazem 💊
  • Diphtheria (Corynebacterium diphtheriae)
  • Diplopia (Double Vision)
  • Dipyridamole 💊
  • Discharges against advice
  • Discoid lupus erythematosus (DLE)
  • Disease prevention/screening
  • Diseases with associated cancers
  • Dislocation Sternoclaivcular joint
  • Disopyramide 💊
  • Disseminated Intravascular Coagulation (DIC)
  • Distal Humerus Fracture
  • Distal Radius Fracture
  • Distributive Shock (Reduced SVR vasodilated)
  • Disulfiram (Antabuse) 💊
  • Diuretics
  • Diverticular disease and Acute Diverticulitis ✅
  • Diving Physiology
  • Dizziness
  • Dobutamine 💊
  • Dog Bites ✅
  • Domestic Violence and Safeguarding NHS
  • Domperidone 💊
  • Donepezil (Aricept) 💊
  • Donovanosis
  • Dopamine Hydrochloride 💊
  • Dopamine agonists 💊
  • Dornase Alpha ✅
  • Dosing Gentamicin
  • Downs syndrome
  • Doxapram 💊
  • Doxazosin (Cardura) 💊
  • Doxepin 💊
  • Doxorubicin (Adriamycin)
  • Doxycycline 💊
  • Driving Advice
  • Drowning ✅
  • Drug Induced Parkinson disease
  • Drug Metabolism
  • Drug Overdose Adults
  • Drug Reaction Eosinophilia Systemic Symptoms (DRESS syndrome)
  • Drug Toxicity Assessment and Management ⚠️
  • Drug induced Lupus Erythematosus
  • Drug induced liver disease
  • Drug overdose children ✅
  • Drugs
  • Drugs to Avoid in Acute Renal failure
  • Drugs to avoid in Liver failure
  • Dry and Wet and Gas Gangrene
  • Dual X-ray absorptiometry (DEXA)
  • Duchenne Muscular Dystrophy
  • Duke’s Criteria for Infective Endocarditis ✅
  • Dulaglutide GLP-1 agonist 💊
  • Duloxetine 💊
  • Duodenal Atresia (Children)
  • Dupuytrens contracture ✅
  • Dural Arteriovenous Malformations
  • Dysmorphic child
  • Dyspepsia (OSCE focused)
  • Dysphagia / Swallowing Problems ✅
  • ECG - Acute Coronary Syndrome ❤️
  • ECG - Artefact
  • ECG - Asystole and P wave Asystole
  • ECG - Bundle Branch Blocks
  • ECG - Calculate the electrical axis
  • ECG - Causes of a Dominant R wave in V1 ❤️
  • ECG - Collection A
  • ECG - Collection B
  • ECG - Heart Block
  • ECG - Hyperkalaemia ❤️
  • ECG - Left Axis Deviation
  • ECG - Left Bundle Branch Block LBBB
  • ECG - Left Ventricular Hypertrophy
  • ECG - Low Voltage Complexes
  • ECG - NSTEMI
  • ECG - Normal 12 Lead
  • ECG - P wave
  • ECG - Pathological Q waves
  • ECG - Potential Errors
  • ECG - QT interval ❤️
  • ECG - Right Axis Deviation
  • ECG - Right Bundle Branch Block RBBB
  • ECG - Right Ventricular Hypertrophy
  • ECG - ST segment changes
  • ECG - ST-T T waves changes
  • ECG - STEMI
  • ECG - Sinoatrial block ❤️
  • ECG - Sinus Bradycardia
  • ECG - The QRS complex
  • ECG - short PR interval
  • ECG Analysis
  • ECG Reading & Interpretation MLA and Exams 🫀
  • ECG/EKG Crib sheets
  • EEG (Electroencephalogram)
  • ENT Emergencies: Revision ✅
  • ENT infections
  • ENT: Common Ear disorders
  • ENT: Common Nose and Throat disorders
  • ENT: Emergenices
  • ENT: Neck lumps and cancer
  • Ear Pain (Otalgia)
  • Ear and Nasal Discharge
  • Eating Disorders
  • Ebola Virus Disease ✅
  • Ebstein anomaly ❤️
  • Echinocytes
  • Ecstasy toxicity⚠️
  • Ectopia lentis (subluxation of the lens)
  • Ectopic Pregnancy
  • Ectropion
  • Eculizumab 💊
  • Eczema/Dermatitis
  • Edoxaban (Lixiana)
  • Edward syndrome (trisomy 18 syndrome)
  • Efavirenz (Sustiva) EFV 💊
  • Ehlers-Danlos syndromes
  • Ehrlichiosis
  • Eikenella corrodens
  • Eisenmenger's syndrome ❤️
  • Elation/elated mood
  • Elbow Dislocation
  • Elder Abuse and Safeguarding
  • Elderly Medicine / Geriatrics Revision Guide ✅
  • Electrical Storm (Recurrent VT/VF)
  • Electrical injury
  • Electrolyte Abnormalities
  • Electron Transport Chain
  • Embryology of Blood and Immune System
  • Embryology of Limb Development
  • Embryology of Nervous system
  • Embryology of Organ Development
  • Emergency Drugs Collection
  • Emergency Medicine Revision Guide✅
  • Emphysema
  • Empty sella syndrome
  • Emtricitabine (Emtriva) FTC 💊
  • Enalapril 💊
  • Encephalocoele
  • Encopresis in Children ✅
  • End of Life Care Prescribing ✅
  • End of Life care in Diabetes
  • End of life care in Head & Neck cancer
  • Endocrine Emergencies: Revision ✅
  • Endocrine: Anatomy Physiology and Pharmacology
  • Endocrinology Revision Guide ✅
  • Endocrinology: Adrenal Disease
  • Endocrinology: Diabetes
  • Endocrinology: Lipids and obesity
  • Endocrinology: NETS and Hypoglycaemia
  • Endocrinology: Pituitary Disease
  • Endocrinology: Reproductive
  • Endocrinology: Sodium and Water disorders
  • Endocrinology: Thyroid disease
  • Endocrinology:: Emergencies
  • Endocrinology::Bone Medicine
  • Endometrial (Uterine) Cancer
  • Endometriosis
  • Endophthalmitis ✅
  • Endoscopic Retrograde Cholangiopancreatography (ERCP)
  • Endothelins
  • Enfuvirtide 💊
  • Enoxaparin Sodium (Clexane-Lovenox) 💊
  • Enoximone 💊
  • Entacapone
  • Enteric Fever (Typhoid/Paratyphoid) ✅
  • Enterococci
  • Enteropathic Spondyloarthritis
  • Entropion
  • Enuresis/Bedwetting in Children ✅
  • Enzyme inducers and inhibitors
  • Enzymes in Humans
  • Eosinophilic Oesophagitis
  • Eosinophilic granulomatosis (Churg Strauss)
  • Ependymoma
  • Epididymitis and Orchitis (Children)✅
  • Epididymitis and Orchitis in Adults
  • Epidural Haematoma
  • Epidural Spinal abscess
  • Epilepsy - Diagnosis
  • Epilepsy - Idiopathic Generalised Epilepsy
  • Epilepsy in Pregnancy
  • Epilepsy ✅
  • Episcleritis
  • Epistaxis
  • Eplerenone 💊
  • Eponymous brainstem strokes
  • Epstein-Barr Virus infection
  • Equality Diversity and Human Rights
  • Equality Diversity and Inclusion
  • Erb Palsy
  • Erectile dysfunction
  • Ergocalciferol (Calciferol) 💊
  • Erlotinib (Tarceva) 💊
  • Erysipelas ✅
  • Erysipelothrix rhusiopathiae
  • Erythema Gyratum Repens
  • Erythema Multiforme ✅
  • Erythema Nodosum
  • Erythema ab Igne
  • Erythrocytes / Red Blood Cells 🩸
  • Erythrodermic Psoriasis
  • Erythromycin 💊
  • Escherichia coli (E. coli)
  • Escitalopram 💊
  • Esomeprazole 💊
  • Essential Hypertension ✅
  • Essential Thrombocythaemia (ET) ✅
  • Essential Tremor
  • Etanercept 💊
  • Ethambutol 💊
  • Ethanol toxicity⚠️
  • Ethanol 💊
  • Ethylene glycol toxicity
  • Etomidate
  • Etravirine (intelence) ETR 💊
  • Euglycaemic Ketoacidosis (euDKA) with SGLT2 Inhibitors
  • Ewing sarcoma
  • Exchange Transfusion
  • Exenatide (Byetta) GLP1 agonist 💊
  • Exercise Physiology
  • Exercise stress test
  • Exploding head syndrome
  • Extradural haemorrhage
  • Extramedullary plasmacytoma
  • Extrapyramidal symptoms
  • Extrinsic Allergic alveolitis (Hypersensitivity Pneumonitis)
  • Eye Collection
  • Eye Trauma
  • Eye infections
  • Eye pain/discomfort
  • Ezetimibe 💊
  • FDG PET/CT Scans
  • Fabry disease
  • Facial Nerve (VII Cranial nerve)
  • Facial and Periorbital Swelling
  • Facial pain
  • Facioscapulohumeral muscular dystrophy
  • Factor V Leiden Deficiency
  • Faecal Calprotectin
  • Faecal Incontinence
  • Failure to thrive or Faltering growth
  • Falls
  • Familial Adenomatous polyposis (FAP) ✅
  • Familial Hyperlipidaemias
  • Familial Mediterranean Fever (FMF) ✅
  • Familial hypocalciuric hypercalcaemia (FHH)
  • Familial/Hereditary Amyloidosis
  • Family Tree (Pedigree)
  • Family history of possible genetic disorder
  • Famotidine 💊
  • Famous Medical Triads
  • Fanconi Anaemia
  • Fanconi Syndrome
  • Farmer's lung
  • Fasciculation
  • Fast Atrial Fibrillation and Rate Control
  • Fat Metabolism
  • Fat embolism ✅
  • Fatal Familial Insomnia (FFI)
  • Fatty acids
  • Febrile convulsion
  • Felodipine (Dihydropyridine)
  • Femoral Hernia
  • Femoral Shaft Fractures
  • Femoral Vein Cannulation
  • Femoral nerve
  • Fentanyl - Fentanil
  • Ferritin
  • Ferrous Fumarate - Gluconate - Sulphate 💊
  • Fertilisation and Formation of Zygote
  • Fetal Alcohol Syndrome
  • Fetal-type Posterior cerebral artery (FTP)
  • Fever - all ages
  • Fever Pyrexia of unknown origin (FUO PUO)
  • Fever in IV Drug User (PUO)
  • Fever in a traveller
  • Fibrinogen
  • Fibromuscular Dysplasia ✅
  • Fibromyalgia ✅
  • Fibrotic Lung Disease
  • Fidaxomicin 💊
  • Fifth Disease (Erythrovirus B19 infection)
  • Finasteride (5 alpha-reductase inhibitor) 💊
  • Fire Safety for NHS Professionals
  • First Seizure
  • First Seizure (OSCE focused)
  • Fissure in Ano
  • Fistulo in Ano
  • Fit Notes in General Practice (UK)
  • Fits/seizures and Epilepsy (Children)
  • Fitz-Hugh Curtis Syndrome
  • Fixed Abnormal Beliefs (Delusions)
  • Flashes and Floaters in the Visual Field
  • Flecainide Acetate 💊
  • Flexor sheath infection (flexor tenosynovitis)
  • Flow Cytometry
  • Flucloxacillin 💊
  • Fluconazole 💊
  • Flucytosine 💊
  • Fludrocortisone 💊
  • Fluid balance status and management
  • Flumazenil (Annexate - Romazicon) 💊
  • Fluoxetine 💊
  • Focal Cortical Dysplasia (FCD)
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Foix-Alajouanine syndrome
  • Folate (Folic) acid (B9) 💊
  • Folate deficiency (B9) ✅
  • Folinic acid (Leucovorin) 💊
  • Follicular lymphoma
  • Folliculitis
  • Fomepizole 💊
  • Fondaparinux 💊
  • Food Intolerance in Children
  • Food borne disease
  • Foot Drop
  • Forearm Fractures
  • Foreign Body in Eye
  • Foscarnet Sodium 💊
  • Fosfomycin
  • Foslevodopa / Foscarbidopa
  • Fosphenytoin 💊
  • Foster Kennedy Syndrome
  • Fourniers gangrene
  • Fractured Clavicle
  • Fractured Neck of Femur/Femoral Neck
  • Fractured Pubic Ramus
  • Fractured Scapula
  • Fractured Shaft Femur
  • Fractured Tibia and Fibula
  • Fractures in Children
  • Fractures of the Upper humerus
  • Fragile X syndrome
  • Frailty an Overview
  • Fraser guidelines and Gillick Competence
  • Free Radicals
  • Fresh Frozen Plasma
  • Friedreichs Ataxia
  • Frontotemporal dementia
  • Full or Complete Blood Count (FBC CBC)
  • Functional organization of a eukaryotic gene
  • Fungi and their infections
  • Furosemide (Frusemide)
  • Fusidic acid 💊
  • Fusobacteria - Tropical ulcer
  • Fusobacterium
  • G protein-coupled receptors
  • GLP-1 Receptor Agonists
  • Gabapentin 💊
  • Galactorrhoea
  • Galactosaemia
  • Galantamine
  • Gallstone ileus
  • Gallstones and biliary colic
  • Gamete intra-fallopian tube transfer (GIFT)
  • Gametogenesis
  • Gamma Glutamyl Transferase (GGT)
  • Gamma hydroxy butyrate (GHB) toxicity⚠️
  • Ganciclovir - Valganciclovir 💊
  • Ganglion Cysts
  • Gardner's syndrome
  • Gardnerella vaginalis
  • Gas Gangrene (Clostridial Myonecrosis)
  • Gastric (MALT) Lymphoma
  • Gastric Cancer ✅
  • Gastric Outlet obstruction (pyloric stenosis) in Adults ✅
  • Gastrinoma
  • Gastro Intestinal Stromal Tumours (GIST)
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  • Gastroenterology Revision Article ✅
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  • Gastroenterology: Gastroenterology Emergencies (Complete)
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  • Geriatric Medicine Syllabus (For Resident Doctors in Training)
  • Gerstmann-Straussler-Scheinker Syndrome (GSS)
  • Gestational Diabetes Mellitus ✅
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  • Glucagonoma
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  • Growth Hormone Deficiency ✅
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  • Haematology Emergencies: Revision ✅
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  • Hierarchy of Evidence-Based Trials
  • High Altitude Physiology
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  • Hirschsprung disease (congenital megacolon)
  • Hirsuitism
  • Histones
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  • Hodgkin Lymphoma ✅
  • Hodgkin vs Non-Hodgkin Lymphoma:
  • Holt-Oram syndrome
  • Holter monitor (tape) 24-72 h
  • Homocystinuria
  • Hookworm
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  • Horseshoe Kidney
  • Hospital acquired Pneumonia HAP ✅
  • Hospital-acquired infections
  • How does a CPU work
  • How to Read and Analyze a Medical Paper
  • Human Herpesvirus 6A (HHV-6A)
  • Human Leukocyte Antigen (HLA) and its Role in Disease Associations
  • Human Metabolism
  • Human albumin solution (HAS)
  • Human papilloma virus infection
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  • Humeral Fractures ✅
  • Hunter's syndrome (MPS-2)
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  • Hyphaema (US Hyphema)
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  • Hypoglossal Nerve (Cranial Nerve XII)
  • Hypoglycaemia
  • Hypogonadism
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  • Hypokalaemia
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  • Hypomagnesaemia ✅
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  • Hypopituitarism (Pituitary Failure)
  • Hypospadias
  • Hypothermia✅
  • Hypothyroidism ✅
  • Hypoxia - Reacting to Low Oxygen Saturations
  • Hypoxic-Ischaemic Encephalopathy
  • ICH Classification and Severity Scores
  • ID: HIV, viral hepatitis and blood-borne viruses
  • ID: How Infection Happens
  • ID: Sepsis, fever and serious bacterial infections
  • IHD: Chronic stable angina ✅
  • IL-12 receptor deficiency
  • IV Immunoglobulin (IVIG) 💊
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  • Ibuprofen 💊
  • Icatibant 💊
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  • Idiopathic Arthritis in Adults
  • Idiopathic Fascicular Left Ventricular Tachycardia
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  • IgA Nephropathy (Berger's disease)
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  • Images - Spot diagnoses
  • Imaging for the MLA#1
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  • Immobility
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  • Immune Thrombocytopenic Purpura (ITP) 🩸
  • Immune response
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  • Immunoglobulin G4-related disease (IgG4-RD)
  • Immunoglobulins and their role in Immunity
  • Impetigo
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  • Indinavir (IND)
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  • Infection screening in Septic patient ✅
  • Infectious Colitis
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  • Infectious Diseases Revision Guide ✅
  • Infectious Mononucleosis (EBV Most Often)
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  • Insomnia - unable to sleep issues
  • Insulin Degludec (Tresiba)
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  • Insulin Physiology
  • Insulin Pumps
  • Insulinoma
  • Interferon Beta 💊
  • Intermittent Claudication
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  • Internal Jugular vein Cannulation
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  • Internuclear Ophthalmoplegia
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  • Intestinal Ischaemia
  • Intestinal obstruction (Children)
  • Intestinal obstruction and Ileus
  • Intra Aortic Balloon Pump
  • Intraabdominal abscess
  • Intrauterine death ✅
  • Intravascular large B-cell lymphoma (IVLBCL)
  • Intravenous Iron Replacement
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  • Intraventricular haemorrhage (neonates)
  • Introduction to Anaesthetics 💤
  • Introduction to Hormones
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  • Intubation and Mechanical Ventilation
  • Intussusception in Adults
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  • Investigations
  • Iodine Physiology
  • Iodine deficiency Goitre
  • Ipratropium Bromide (Atrovent) 💊
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  • Iritis (Anterior Uveitis)
  • Iron Salts 💊
  • Iron Studies
  • Iron Studies
  • Iron deficiency Anaemia 🩸
  • Iron toxicity⚠️
  • Irritable bowel syndrome ✅
  • Ischaemic Colitis
  • Ischaemic Heart Disease: Decubitus Angina
  • Ischaemic Stroke
  • Ischaemic Strokes in the Pons
  • Ischaemic heart disease (Complete Includes ACS management)
  • Isoniazid 💊
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  • Isosorbide Dinitrate 💊
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  • Isotretinoin (Accutane) 💊
  • Ispaghula Husk (Fybogel) 💊
  • Ivabradine 💊
  • Ivermectin
  • Jansen Disease
  • Janus kinase 2
  • Jaundice
  • Java Programming
  • Jervell and Lange-Nielsen syndrome
  • Job Syndrome (Hyper IgE syndrome)
  • Jugular Venous pressure
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  • Juvenile Dermatomyositis
  • Juvenile Idiopathic Arthritis (Stills Disease)
  • Juvenile Myoclonic epilepsy (JME)
  • Kallmanns syndrome
  • Kaposi sarcoma (KS)
  • Karnofsky performance status scale
  • Kawasaki disease
  • Keloids
  • Kennedy Syndrome (Spinal and Bulbar Muscular Atrophy (SBMA))
  • Keratoacanthoma
  • Keratoconus
  • Kernicterus
  • Ketamine bladder
  • Ketamine 💊
  • Ketoconazole 💊
  • Ketones
  • Klebsiella pneumonia
  • Kleine Levin Syndrome
  • Klinefelter Syndrome
  • Klumpke palsy
  • Knee Joint Structure and Form
  • Koebner phenomenon
  • Kugelberg-Welander Syndrome (Spinal Muscular Atrophy Type III)
  • Kuru
  • Kwashiorkor
  • L-Thyroxine (T4) 💊
  • Labetalol (Trandate) 💊
  • Labour and Complications
  • Labyrinthitis and Vestibular Neuronitis
  • Lac operon
  • Lacerations
  • Lacerations
  • Lactate
  • Lactate dehydrogenase (LDH)
  • Lactic acidosis
  • Lactobacillus acidophilus
  • Lactose Intolerance
  • Lactulose 💊
  • Lacunar Stroke Syndromes
  • Lady Windermere syndrome
  • Lambert-Eaton syndrome (LEMS)
  • Lamivudine (3TC) 💊
  • Lamotrigine 💊
  • Langerhans cell histiocytosis (LCH)
  • Language and Dysphasia
  • Lansoprazole 💊
  • Lanthanum
  • Large for Gestational Age (LGA)
  • Larva Currens (Strongyloides stercoralis)
  • Lassa haemorrhagic fever (LHF)
  • Lateral Medullary Syndrome
  • Law and Mental Health (UK)
  • Law and Mental Health (USA)
  • Laxatives 💊
  • Le Fort Fractures
  • Lead toxicity
  • Learning (Intellectual) disability
  • Leber hereditary optic neuropathy (LHON)
  • Lecanemab (Leqembi)
  • Leflunomide (Arava) 💊
  • Left Ventricular Outflow Tract (LVOT) Tachycardia
  • Legal definition of Blindness
  • Legionella Pneumophila
  • Leishmaniasis (Cutanenous and Visceral)
  • Lemierre's syndrome
  • Lenalidomide (Revlimid)
  • Length Dependent Polyneuropathy
  • Lennox-Gastaut syndrome
  • Lenticulostriate branch occlusion
  • Leprosy (Hansen’s disease)
  • Leptin
  • Leptomeningeal Metastases
  • Leptospira interrogans
  • Leptospirosis (Weil's Disease) (Notifiable)
  • Leriche syndrome (aortoiliac occlusive disease)
  • Lesch-Nyhan syndrome
  • Leukaemia
  • Leukoariosis
  • Leukocoria (White Pupillary Reflex) 👁️
  • Leukocyte alkaline phosphatase
  • Leukocytoclastic vasculitis
  • Leukotrienes
  • Levetiracetam (Keppra) 💊
  • Levobupivacaine
  • Levodopa 💊
  • Levomepromazine
  • Levosimendan 💊
  • Lhermitte Duclos Disease
  • Li Fraumeni syndrome
  • Lichen Planus ✅
  • Liddle's syndrome
  • Lidocaine(Lignocaine) 💊
  • Lightning strike
  • Limb Weakness
  • Limb girdle dystrophy
  • Limbic Encephalitis
  • Linagliptin (Trajenta) 💊
  • Linezolid
  • Liothyronine Sodium L-Triiodothyronine (T3) 💊
  • Lipid emulsion therapy - Intralipid 💊
  • Lipoatrophy
  • Lipoprotein lipase deficiency
  • Liraglutide (Victoza) 💊
  • Lisinopril 💊
  • Listerial Meningitis
  • Listeriosis
  • Lithium toxicity⚠️
  • Lithium 💊
  • Livedo Reticularis ✅
  • Liver Biopsy
  • Liver Examination (OSCE)
  • Liver Transplantation
  • Liver abscess ✅
  • Liver disease in Pregnancy
  • Local Anaesthetics for Suturing or other Procedures
  • Localisation of cortical function
  • Locked in Syndrome
  • Lofepramine 💊
  • Loffler's syndrome (Pulmonary Eosinophilia)
  • Loin Pain
  • Long COVID
  • Long QT syndrome (LQTS) Congenital
  • Long chain acyl-CoA dehydrogenase deficiency
  • Long term Oxygen therapy (LTOT)
  • Loop diuretics 💊
  • Loperamide 💊
  • Lopinavir 💊
  • Loratadine 💊
  • Lorazepam 💊
  • Losartan 💊
  • Loss of Libido
  • Loss of red reflex
  • Louse-Borne vs Tick-Borne Relapsing Fever
  • Louse-borne relapsing fever
  • Low CSF pressure Headache
  • Low Mood and Affective Disorders - Depression
  • Lower Gastrointestinal Bleeding ✅
  • Lower Limb Fractures
  • Lower Limb Fractures and Injuries
  • Lower Limb Neurology (OSCE)
  • Lower Limb Soft Tissue Injuries
  • Lower respiratory tract infection (Child)
  • Lown Ganong Levine Syndrome (LGL) AVRT
  • Lugol iodine 💊
  • Lumbar and Sacrum anatomy and function
  • Lumbar puncture
  • Lumbrosacral Radiculopathy
  • Lump in Groin
  • Lung Abscess
  • Lung Cancer ✅
  • Lung Empyema
  • Lung Transplant
  • Lupus Nephritis
  • Lupus Vulgaris
  • Lyme disease
  • Lymphadenopathy
  • Lymphocytes
  • Lymphocytic Hypophysitis
  • Lymphogranuloma Venereum (LGV)
  • Lymphoproliferative Disorders
  • Lyonization (X-Inactivation)
  • Lysergic acid diethylamide (LSD) Toxicity
  • Lysosomal storage diseases
  • MCAD Deficiency (Medium-Chain Acyl-CoA Dehydrogenase Deficiency)
  • MELAS
  • MR cholangiopancreatography (MRCP)
  • Macrocytic anaemia 🩸
  • Macroglossia
  • Macrophage activation syndrome (MAS)
  • Magnesium Physiology
  • Magnesium Sulphate - Sulfate
  • Magnetic resonance cholangiopancreatography
  • Magnetic resonance imaging
  • Major Disaster Plan
  • Major Histocompatibility complex
  • Malabsorption - small intestine ✅
  • Malaria
  • Malaria Falciparum (Cerebral Malaria) ✅
  • Male Urethral Catheterisation
  • Malignant Ascites
  • Malignant Breast Disease
  • Malignant Hyperparathyroidism due to PTHrP
  • Malignant Hyperpyrexia (Malignant Hyperthermia)
  • Malignant Hypertension
  • Malignant MCA syndrome ✅
  • Malignant Melanoma ✅
  • Malignant pleural mesothelioma
  • Mallet Finger
  • Mallory-Weiss Tear
  • Malnutrition Adults and the Elderly
  • Malnutrition Universal Screening Tool
  • Malnutrition universal screening tool (MUST)
  • Management of Bites
  • Mannitol
  • Mantle cell lymphoma
  • Maple Syrup Urine disease
  • Marantic Endocarditis
  • Marasmus
  • Maraviroc (Celsentri) 💊
  • Marburg virus disease
  • Marchiafava Bignami syndrome
  • Marfan syndrome
  • Marginal Keratitis 👁️
  • Marginal Zone Lymphoma
  • Mask-Related Acne (Maskne)
  • Massive Haemorrhage and Massive Transfusion Protocol (MTP)
  • Mastoiditis
  • Maths and Physics Crib Sheets
  • Maturity Onset Diabetes of the Young (MODY)
  • McArdles disease (type V)
  • McCune Albright syndrome
  • Measles (notifiable)
  • Mebeverine 💊
  • Mechanical Thrombectomy for Ischaemic Stroke
  • Meckel diverticulum ✅
  • Meconium
  • Median Nerve
  • Medical Licensing Assessment Content Map (GMC)
  • Medical Tweetorial Links
  • Medical conditions affecting the Teeth
  • Medication Sick-Day Rules
  • Medullary Sponge kidney
  • Medulloblastoma
  • Mefenamic acid 💊
  • Mefloquine (Larium)
  • Megaloblastic anaemia 🩸
  • Melaena
  • Melatonin
  • Melioidosis (Burkholderia pseudomallei)
  • Memantine Hydrochloride 💊
  • Membranous Glomerulonephritis
  • Memory Loss
  • Menetrier disease
  • Menieres disease
  • Meningioma
  • Menkes Disease
  • Menopause and Menopausal Problems 🌸 ✅
  • Menstrual cycle
  • Menstrual problems
  • Mental Capacity Act 2005
  • Mental Health Act 1983
  • Mental capacity concerns
  • Mental health problems in pregnancy or postpartum 🤰
  • Mercaptopurine 💊
  • Meropenem 💊
  • Mesalazine (Aminosalicylate) 💊
  • Mesangiocapillary Glomerulonephritis
  • Mesenteric Ischaemia
  • Mesenteric adenitis
  • Mesial temporal lobe epilepsy
  • Metabolic Syndrome X ✅
  • Metabolic acidosis
  • Metabolic alkalosis
  • Metachromic leukodystrophy
  • Metastatic Adenocarcinoma
  • Metastatic Calcification
  • Metastatic bone disease
  • Metastatic disease
  • Metformin 💊
  • Methaemoglobinaemia
  • Methanol Toxicity
  • Methicillin Resistant Staphylococcus Aureus ✅
  • Methodone 💊
  • Methods to reduce toxin absorption
  • Methotrexate 💊
  • Methylcellulose 💊
  • Methylprednisolone
  • Methylthioninium chloride (Methylene blue)
  • Metoclopramide 💊
  • Metolazone 💊
  • Metoprolol 💊
  • Metronidazole (Flagyl) 💊
  • Metyrapone (Metopirone) 💊
  • Miconazole 💊
  • Microangiopathic Haemolytic anaemia
  • Microbiology and Assessment of Streptococcus
  • Microcytic anaemia 🩸
  • Microscopic Polyangiitis✅
  • Microscopic colitis
  • Microstomia
  • Microtubules
  • Midazolam
  • Middle East Resp Syndrome (MERS) Coronavirus
  • Midodrine 💊
  • Mifepristone
  • Migraine✅
  • Miliary (Disseminated) Tuberculosis
  • Miller-Fisher syndrome
  • Milrinone
  • Milwaukee shoulder syndrome
  • Mini Mental State Examination (MMSE)
  • Minimal Change Disease Glomerulonephritis
  • Minocycline 💊
  • Minoxidil 💊
  • Mirabegron 💊
  • Mirizzi syndrome
  • Mirtazapine 💊
  • Mirvetuximab soravtansine (Elahere)
  • Miscarriage
  • Misoprostol 💊
  • Misplaced Nasogastric tube insertion
  • Mitochondria
  • Mitochondrial diseases
  • Mitosis and Meiosis
  • Mitral Regurgitation (Incompetence)
  • Mitral Stenosis ✅
  • Mitral Stenosis vs Regurgitation
  • Mitral Valve prolapse ❤️
  • Mittelschmerz
  • Mixed Connective Tissue Disease (MCTD)
  • Mobility aids
  • Modified Oxford Handicap Scale (MOHS)
  • Modified Rankin Score
  • Modified Valsalva
  • Molecular Structures for Medicine
  • Molluscum contagiosum
  • MonkeyPox (MPOX)
  • Monoclonal gammopathy Undetermined significance
  • Monocytes 🩸
  • Monogenic diabetes
  • Monosodium glutamate (MSG) syndrome
  • Montelukast 💊
  • Montreal Cognitive Assessment (MOCA)
  • Moraxella catarrhalis
  • Morphine Sulphate 💊
  • Morphological Blood film abnormalities and variants
  • Mosquito borne diseases
  • Most Common Cancers in the UK & Red Flags
  • Motor End Plate
  • Motor Neuron Disease (MND-ALS)
  • Moyamoya disease
  • Muckle Wells syndrome
  • Multifocal Atrial Tachycardia
  • Multifocal Motor Neuropathy with Conduction block
  • Multiple Antithrombotics Anticoagulants
  • Multiple Crib sheets
  • Multiple Endocrine Neoplasia type 1 (MEN1)
  • Multiple Endocrine Neoplasia type II (MEN2)
  • Multiple Myeloma
  • Multiple Organ Dysfunction Syndrome
  • Multiple Pregnancy
  • Multiple Sclerosis (MS) ✅
  • Multiple System Atrophy (MSA)
  • Mumps (Notifiable)
  • Muscle Pain Myalgia
  • Muscular Dystrophies
  • Musculocutaneous nerve
  • Musculoskeletal deformities
  • Musculoskeletal deformities
  • Myasthenia Gravis ✅
  • Mycophenolate mofetil 💊
  • Mycoplasma pneumoniae 🫁
  • Mycoplasmas
  • Mycosis Fungoides (Sezary Syndrome)
  • Myelin Oligodendrocyte Glycoprotein (MOG) & MOG Antibody-Associated Disease (MOGAD)
  • Myelodysplastic syndrome (Myelodysplasia) 🩸
  • Myelofibrosis 🩸
  • Myelopathy (Disorder of Spinal cord)
  • Myeloproliferative disorders ✅
  • Myeloproliferative vs Lymphoproliferative Disorders
  • Myobacterium avium Complex Infection
  • Myocardial perfusion
  • Myoclonus
  • Myoglobin
  • Myotomes
  • Myotonic dystrophy - Dystrophia myotonica
  • Myxoedema coma
  • N-Acetylcysteine (Parvolex) 💊
  • NICE Guidance Part 1 ✅
  • NICE Guidance Part 2 ✅
  • NICE Guidance Part 3 ✅
  • NICE and other guidelines links
  • NICE and other guidelines links✅
  • NSAID toxicity⚠️
  • Nail disorders Table
  • Naloxone (Narcan) Opiate antagonist 💊
  • Naproxen
  • Narcolepsy
  • Narrow Complex Tachycardia ❤️
  • Nasal Discharge
  • Nasal Obstruction
  • Nasal polyps
  • Natalizumab (Tysabri) 💊
  • National Early Warning Score NEWS 2 Score
  • National Institutes of Health Stroke Scale (NIHSS)
  • Natural Language processing
  • Neck Swellings by Triangle
  • Necrotising Enterocolitis
  • Necrotising fasciitis
  • Needlestick injury and PEP
  • Nefopam 💊
  • Neisseria meningitidis (Meningococcus)
  • Nelson Syndrome
  • Nemaline myopathy
  • Neomycin 💊
  • Neonatal Abstinence Syndrome NAS
  • Neonatal Jaundice
  • Neonatal Lupus Erythematosus
  • Neonatal death or cot death
  • Neonatal death or cot death
  • Neonatal meningitis
  • Neostigmine 💊
  • Nephritic vs Nephrotic syndrome
  • Nephroblastoma (Wilm's tumour)
  • Nephrology Revision Guide ✅
  • Nephrotic Syndrome in Children ✅
  • Nephrotic syndrome in Adults
  • Nephrotoxic drugs
  • Nerve conduction studies
  • Neuroanatomy Images
  • Neuroblastoma
  • Neurocysticercosis (Taenia solium a pork parasite)
  • Neuroferrinopathy
  • Neurofibromatosis Type 1
  • Neurofibromatosis Type 2
  • Neuroleptic Malignant Syndrome
  • Neurological Examination - Cortical Functions
  • Neurological Examination - Motor
  • Neurological Examination - Speech&Language
  • Neurological Sensory Examination (OSCE)
  • Neurological examination - Eyes
  • Neurological or ENT Examination - Nystagmus
  • Neurological signs
  • Neurology Chapter
  • Neurology Crib Sheets
  • Neurology Revision Guide ✅
  • Neurology: Basics
  • Neurology: Dementia and Cognition Disorders (Complete)
  • Neurology: Emergencies
  • Neurology: Epilepsy
  • Neurology: Headache and Facial Pain
  • Neurology: Localisation and Investigation
  • Neurology: Movement Disorders
  • Neurology: Multiple Sclerosis and inflammatory disease
  • Neurology: Neuromuscular disease
  • Neurology: Oncology and Hydrocephalus
  • Neurology: Spine and Sleep Disorders
  • Neurology: Stroke Emergencies (Complete)
  • Neuromuscular weakness
  • Neuromyelitis Optica (Devic's disease)
  • Neuropathic Pain Management
  • Neuropathic pain
  • Neuroscience - Vision and Eye movements
  • Neuroscience of Memory
  • Neurosurgery
  • Neurotransmitters
  • Neutropenia
  • Neutropenic Sepsis
  • Neutrophil Alkaline Phosphatase
  • Neutrophils
  • Nevirapine (Viramune) NEV-NVP 💊
  • New Headache (OSCE focused)
  • New Onset Weakness (OSCE focused)
  • Newborn Bloodspot (Heel Prick) Screening
  • Niacin deficiency (Pellagra Vitamin B3)
  • Nicardipine (Cardene)
  • Nicorandil 💊
  • Niemann-Pick disease
  • Nifedipine 💊
  • Night sweats
  • Nikolsky's sign
  • Nimodipine (Nimotop) 💊
  • Nipple Discharge
  • Nirsevimab (Beyfortus)
  • Nitrates
  • Nitric Oxide
  • Nitrofurantoin 💊
  • Nitrous oxide use and abuse
  • Nizatidine 💊
  • Nocardia
  • Noise induced hearing loss
  • Non Alcoholic Fatty Liver Disease MASLD and MASH
  • Non Convulsive Status Epilepticus
  • Non Hodgkin Lymphoma ✅
  • Non gonococcal urethritis
  • Non invasive ventilation (NIV)
  • Non steroidal anti inflammatory drugs (NSAIDs) 💊
  • Non-Arteritic Anterior Ischaemic Optic Neuropathy 👁️
  • Non-accidental injury
  • Non-accidental injury (children)
  • Noonan syndrome
  • Noradrenaline (Norepinephrine) 💊
  • Normal Distribution
  • Normal Pressure Hydrocephalus
  • Normal Saline 0.9% ✅
  • Normal pregnancy and Antenatal care
  • Normocytic anaemia
  • Norovirus
  • Nortriptyline 💊
  • Norwegian Scabies ✅
  • Nosocomial infections
  • Notifiable disease and organisms UK
  • Nucleotides
  • Nutrition in Infants Breastfeeding
  • Nystatin 💊
  • OSCE Abdominal Examination
  • OSCE Ascites Examination
  • OSCE Blood pressure
  • OSCE Breast Anatomy Exam
  • OSCE Cardiac History Taking
  • OSCE Causes of Male Infertility
  • OSCE Cranial nerves and examination
  • OSCE Dysphagia Swallowing
  • OSCE Ear Examination
  • OSCE Examination of Visual Fields
  • OSCE Examining for Finger Clubbing
  • OSCE Examining the Arterial Pulse
  • OSCE Examining the Jugular Venous Pressure (JVP)
  • OSCE Eye Examination
  • OSCE Failure to Thrive
  • OSCE Gastroenterology History taking
  • OSCE Inguinal Examination
  • OSCE Jaundice
  • OSCE Leg Pain & Swelling
  • OSCE Lower Limb Neurological Examination
  • OSCE Male Genital exam
  • OSCE Monocular loss of vision
  • OSCE Neurological Examination - Cognition
  • OSCE Neurological Examination Face
  • OSCE Neurology - History taking
  • OSCE Rectal Bleeding
  • OSCE Respiratory - History Taking
  • OSCE Shoulder exam
  • OSCE Station Hearing Loss
  • OSCE Station – Melaena
  • OSCE Testicular/Scrotal Examination
  • OSCE Thyroid Exam
  • OSCE Unintentional Weight Loss
  • OSCE Upper Limb Neurology Examination
  • Obesity
  • Obesity and Pregnancy
  • Object orientated programming
  • Obsessive-Compulsive disorder
  • Obstetric definitions
  • Obstetrics
  • Obstetrics Emergencies: Revision✅
  • Obstetrics and Gynaecology Revision Guide ✅
  • Obstetrics: Antenatal Care
  • Obstetrics: Complications
  • Obstetrics: Medical Problems
  • Obstetrics: Obstetrics: Emergencies
  • Obstetrics: Post Natal Care
  • Obstructive Lung Diseases
  • Obstructive Shock (Mechanical Obstruction)
  • Obstructive Sleep Apnoea
  • Occupational Lung Disease
  • Octreotide 💊
  • Oculomotor Nerve (Cranial Nerve III)
  • Oesophageal Carcinoma
  • Oesophageal Perforation - Rupture
  • Oesophageal Variceal Bleeding
  • Oesophagogastroduodenoscopy (OGD/EGD)
  • Olanzapine 💊
  • Older Patient with Swallowing Problems
  • Olecranon Fracture
  • Olfactory Nerve (Cranial Nerve I)
  • Oligodendroglioma
  • Olmersartan 💊
  • Olsalazine (Aminosalicylate) 💊
  • Omalizumab
  • Omeprazole 💊
  • Onchocerciasis
  • Oncogenic viruses
  • Oncology Revision Guide ✅
  • Oncology: Breast and Gynae Cancers
  • Oncology: Emergencies
  • Oncology: Principles
  • Oncology: Skin Cancer
  • Oncology: Urology and Genital cancers
  • Ondansetron 💊
  • Ophthalmic Emergencies: Revision ✅
  • Ophthalmic Nerve
  • Ophthalmology Basics Cataract Glaucoma
  • Ophthalmology Exam Lists
  • Ophthalmology Revision Guide ✅
  • Ophthalmology: Neuro-ophthalmology
  • Ophthalmology: Paediatrics
  • Ophthalmology: Red emergencies
  • Ophthalmology: Retinal Visual Loss
  • Opiates 💊
  • Opicapone 💊
  • Opioid/Opiate toxicity⚠️
  • Opsonisation
  • Optic Nerve (Cranial Nerve II) and tract
  • Optic Neuritis
  • Optic atrophy
  • Optics Pathway
  • Oral Aphthous Ulcers
  • Oral Candidiasis
  • Oral Leukoplakia
  • Orbital Cellulitis vs Preorbital Cellulitis
  • Orf (Contagious Ecthyma)
  • Organism and sensitivities
  • Organomegaly
  • Organophosphate (OP) Toxicity
  • Orphenadrine
  • Orthopaedics Revision Guide ✅
  • Orthostatic Hypotension
  • Orthostatic Hypotension
  • Oseltamivir - Tamiflu 💊
  • Osteoarthritis
  • Osteochondroma
  • Osteogenesis Imperfecta
  • Osteogenic sarcoma (Osteosarcoma)
  • Osteomalacia
  • Osteomyelitis ✅
  • Osteonecrosis of the jaw
  • Osteopetrosis
  • Osteoporosis ✅
  • Otitis Externa (Malignant)
  • Otitis Media
  • Otosclerosis
  • Ottawa rules for ankle and foot x-ray
  • Ovarian Cancer
  • Ovarian Cyst
  • Ovarian Torsion
  • Overlap Syndrome
  • Oxford / Bamford Classification
  • Oxford Hip Score ✅
  • Oxford community stroke project (Bamford)
  • Oxidation and Reduction for Medical Students
  • Oxybutynin (Ditropan) 💊
  • Oxycodone (Oxycontin-Oxynorm) 💊
  • Oxygen delivery devices
  • Oxygenation and Ventilation
  • Oxytetracycline 💊
  • POEMS syndrome
  • Pabrinex 💊
  • Pacemakers
  • Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections
  • Paediatric Crib Sheets
  • Paediatric emergencies
  • Paediatrics
  • Paediatrics Revision Guide ✅
  • Paediatrics: Gastro Surgery
  • Paediatrics: Growth Development
  • Paediatrics: Infections
  • Paediatrics: Neonatology
  • Paediatrics: Renal Endocrine
  • Paediatrics:Neurology MSK
  • Pagets (Bone) disease
  • Pain Management : Acute & Chronic
  • Pain on inspiration
  • Painful Sexual Intercourse (Dyspareunia)
  • Painful Shoulder syndromes
  • Painful swollen leg
  • Palliation - Nausea Dyspnoea Secretions Pain
  • Palliation prescribing
  • Palliative Care Revision Article ✅
  • Palliative: End of Life Care
  • Palliative: Symptoms Management
  • Pallor
  • Palpitations
  • Pamidronate (Bisphosphonate) 💊
  • Panayiotopoulos Syndrome in Children
  • Pancoast tumour (Cancer)
  • Pancreatic Cancer
  • Pancytopenia
  • Panic Disorder
  • Panton-Valentine leucocidin toxin
  • Pantoprazole 💊
  • Pantothenate Kinase–Associated Neurodegeneration
  • Papilloedema
  • Paracetamol (Acetaminophen) toxicity⚠️
  • Paracetamol (Acetaminophen) 💊
  • Paracoccidioidomycosis
  • Paradoxical embolisation
  • Paraneoplastic Limbic Encephalitis (Dementia)
  • Paraneoplastic cerebellar degeneration
  • Paraphimosis (urological emergency)
  • Paraquat toxicity⚠️
  • Parkinson Plus syndromes
  • Parkinson disease
  • Parkinsonism
  • Parkinsonism–hyperpyrexia syndrome
  • Paronychia
  • Parotitis
  • Paroxetine 💊
  • Paroxysmal Nocturnal Haemoglobinuria
  • Pasteurella multocida
  • Patau syndrome (trisomy 13)
  • Patellar Bursitis
  • Patent Ductus arteriosus (PDA) ❤️
  • Patent Foramen Ovale (PFO)
  • Pathological Gaits 🚶‍♂️
  • Pathological bone fracture
  • Patient on Anticoagulant and Antiplatelet Therapy
  • Patients who refuse treatment or lack capacity
  • Patiromer 💊
  • Pattern Recognition Receptors
  • Pectus Excavatum
  • Pegvisomant 💊
  • Pelvic Abscess
  • Pelvic Inflammatory Disease ✅
  • Pelvic Mass
  • Pelvic Pain
  • Pelvic fractures
  • Pemphigoid Gestationis (Herpes Gestationis) ✅
  • Pemphigus Vulgaris
  • Penetrating Abdominal Trauma ✅
  • Penicillamine 💊
  • Penicillin Allergy
  • Penicillins 💊
  • Penile Cancer
  • Peptic ulcer disease (PUD) and gastritis in Children
  • Peptic ulcer disease and Gastritis in Adults
  • Percutaneous Endoscopic Gastrostomy (PEG) procedure:
  • Pergolide
  • Perianal abscesses and fistulae ✅
  • Perianal symptoms
  • Pericardial Disease
  • Pericardial Effusion and Tamponade ✅
  • Perimesencephalic Subarachnoid haemorrhage ✅
  • Perindopril 💊
  • Perinephric abscess
  • Perioperative Anticoagulation
  • Perioperative Medicine ✅
  • Peripheral Arterial Disease (PAD) ✅
  • Peripheral Nerve Palsies
  • Peripheral nerve injuries/palsies (Children)
  • Peripheral neuropathy
  • Peripheral oedema and ankle swelling
  • Peripherally inserted central catheters (PICC)
  • Peritonitis
  • Peritonsillar Abscess (Quinsy) ✅
  • Pernicious anaemia
  • Personality Disorders
  • Personality, eating and neurodevelopmental disorders
  • Perthes disease (Osteochondritis of the Hip)
  • Petechial Rash in Adult or Child
  • Pethidine
  • Peutz-Jeghers syndrome
  • Peyronie’s Disease
  • Phaeochromocytoma
  • Phagocytes
  • Pharmacokinetic
  • Pharmacokinetics
  • Pharmacology in the Elderly
  • Pharyngeal arch derivatives
  • Pharyngitis
  • Phenobarbital sodium
  • Phenoxymethylpenicillin (Penicillin V) 💊
  • Phentolamine 💊
  • Phenylketonuria (PKU)
  • Phenytoin (Dilantin) 💊
  • Philadelphia chromosome
  • Phimosis
  • Phobic disorders
  • Phocomelia and Thalidomide
  • Phosphorus/Phosphate
  • Phthiriasis palpebrarum ✅
  • Physical Education
  • Physics of flow for Medical students
  • Picolax - Citrafleet 💊
  • Pilonidal Abscess (sinus) ✅
  • Pinta (Treponema carateum)
  • Pioglitazone (Thiazolidinediones) 💊
  • Pituitary Apoplexy
  • Pituitary Tumours
  • Pityriasis or Tinea versicolor infections
  • Pityriasis rosea
  • Pivmecillinam (a penicillin antibiotic) 💊
  • Placenta praevia
  • Placental abruption
  • Plantar fasciitis
  • Plasmapheresis
  • Plasmids
  • Platelets
  • Pleural effusion
  • Pleural tap (thoracentesis)
  • Pneumococcal meningitis ✅
  • Pneumoconiosis ✅
  • Pneumocystis jirovecii pneumonia
  • Pneumonia in Children
  • Pneumonia 🩺 (OSCE focused)
  • Poisoning
  • Poisons eliminated Haemodialysis - perfusion
  • Poliomyelitis
  • Polyarteritis nodosa (PAN)
  • Polyarticular arthritis
  • Polycystic Ovary syndrome
  • Polycythaemia
  • Polycythaemia Vera (Primary Polycythaemia) ✅
  • Polydipsia (thirst)
  • Polymerase chain reaction
  • Polymorphic light eruption
  • Polymyalgia Rheumatica
  • Polymyositis
  • Polypharmacy and STOPP/START criteria
  • Polyuria
  • Polyuria and Thirst (OSCE focused)
  • Pontiac fever (Legionella Pneumophila)
  • Pontine-Midbrain haemorrhage ✅
  • Popliteal Artery Aneurysm
  • Porphyria Cutanea Tarda (PCT)
  • Porphyria Testing
  • Portal Hypertension
  • Positron and Single photon Emission Tomography
  • Post Falls Assessment
  • Post Menopausal Bleeding
  • Post Partum Thyroiditis
  • Post Polio Syndrome (PPS)
  • Post Streptococcal/Infectious Glomerulonephritis
  • Post Stroke Epilepsy (PSE)
  • Post-Traumatic Stress Disorder (PTSD)
  • Post-exposure prophylaxis with Immunoglobulins
  • Post-operative surgical care and complications
  • Post-transplant lymphoproliferative disorders (PTLDs)
  • Posterior Reversible Encephalopathy Syndrome (PRES)
  • Posterior circulation
  • Postmenopausal Bleeding (OSCE focused)
  • Postnatal Depression
  • Postpartum Haemorrhage ✅
  • Postpartum Psychosis
  • Postprandial hypotension
  • Postural Orthostatic Tachycardia Syndrome (POTS)
  • Post‑fall management: Concerns for the On‑Call Team
  • Potassium Physiology
  • Pralidoxime 💊
  • Pramipexole (Mirapexin) 💊
  • Prasugrel 💊
  • Pravastatin 💊
  • Praziquantel
  • Prazosin 💊
  • Pre-Operative Assessment
  • Pre-eclampsia, Gestational Hypertension
  • Prednisolone 💊
  • Prednisone 💊
  • Pregabalin 💊
  • Pregnancy risk assessment
  • Premature Menopause
  • Prematurity
  • Premed Anatomy
  • Premed Pathology 🔬
  • Premed Pharmacology
  • Premedical Biochemistry
  • Premedical Immunology 🧠
  • Premedical Microbiology 🧫
  • Presbyacusis(Presbycusis)
  • Prescribing in Pregnancy
  • Pressure sores or ulcers
  • Preterm labour
  • Prevotella (Bacteroides) melaninogenica
  • Priapism ✅
  • Primaquine
  • Primary Biliary Cholangitis
  • Primary CNS Lymphoma (PCNSL)
  • Primary Familial Brain Calcification (PFBC) Fahr Syndrome
  • Primary Open-Angle Glaucoma (POAG)
  • Primary Pulmonary Hypertension
  • Primary Sclerosing Cholangitis
  • Primary amoebic meningoencephalitis (PAM)
  • Primary and Secondary Hypoparathyroidism ✅
  • Primary ciliary dyskinesia and Kartagener's syndrome
  • Primary hyperaldosteronism (Conn's syndrome)
  • Primary progressive aphasia (Dementia)
  • Probenecid 💊
  • Procalcitonin (PCT) 🧪
  • Prochlorperazine (Stemetil) 💊
  • Procyclidine
  • Progressive Multifocal Leukoencephalopathy (PML)
  • Progressive Supranuclear Palsy (PSP)
  • Prolactin
  • Prolactinoma ✅
  • Propafenone 💊
  • Propantheline 💊
  • Propionibacterium
  • Propofol 💊
  • Propranolol 💊
  • Propylthiouracil 💊
  • Prostate cancer✅
  • Prosthetic Metal and Tissue Valves
  • Protamine Sulfate 💊
  • Protein C Deficiency ✅
  • Protein S Deficiency
  • Protein Synthesis
  • Protein losing enteropathy
  • Protein metabolism
  • Protein p53
  • Proteus
  • Prothrombin 20210A mutation
  • Prothrombin Complex Concentrates (Octaplex and Beriplex) 💊
  • Prothrombin time and Coagulation 🩸
  • Prothrombotic Hypercoagulable disorders
  • Proximal myopathy
  • Prucalopride
  • Pruritis
  • Pruritis ani
  • Psammoma bodies 🌀
  • Pseudo(pseudo)hypoparathyroidism
  • Pseudomonas infection (Pseudomonas aeruginosa)
  • Psoriasis
  • Psoriatic arthritis ✅
  • Psychiatric emergencies
  • Psychiatry Revision Guide✅
  • Psychiatry: Alcohol, drugs and addiction
  • Psychiatry: Anxiety, stress and somatic disorders
  • Psychiatry: Mood disorders
  • Psychiatry: Psychosis and schizophrenia
  • Psychiatry: Safeguarding
  • Psychiatry: assessment, treatment and the law
  • Psychogenic Polydipsia
  • Pubertal Development
  • Pubic Lice (Pediculosis Pubis)
  • Pulmonary Alveolar Proteinosis
  • Pulmonary Arteriovenous malformation
  • Pulmonary Arteriovenous malformation
  • Pulmonary Embolism 🫁
  • Pulmonary Eosinophilia and CXR changes
  • Pulmonary Haemorrhage
  • Pulmonary Hypertension
  • Pulmonary Regurgitation ❤️
  • Pulmonary Stenosis ❤️
  • Pulmonary-renal syndromes ✅
  • Pulmonry Embolism in Pregnancy 🤰
  • Pulse oximetry
  • Pupils : Relative Afferent pupillary defect (RAPD)
  • Purpura
  • Purpura Fulminans
  • Putamen and Globus Pallidus
  • Putaminal Haemorrhage
  • Pyloric Stenosis Children
  • Pyoderma gangrenosum ✅
  • Pyonephrosis
  • Pyrazinamide 💊
  • Pyridostigmine 💊
  • Pyroglutamic acidosis
  • Pyruvate Kinase deficiency
  • Python Programming
  • QRISK3 (OSCE focused) ❤️
  • Quetiapine 💊
  • Quinine toxicity⚠️
  • Quinine 💊
  • RFS Rib fracture score
  • ROSIER scale
  • Rabies
  • Radial Head and Neck Fractures
  • Radial Ulnar and Median Palsy of the Hand
  • Radial nerve
  • Radiation exposure
  • Radicular syndromes
  • Radiculopathies
  • Radioactive iodine (I 131)
  • Radiofrequency Catheter Ablation
  • Radiologically Inserted Gastrostomy (RIG) Procedure
  • Radiology for finals
  • Raised intracranial pressure (ICP)
  • Raloxifene 💊
  • Raltegravir 💊
  • Ramipril 💊
  • Ramsay Hunt syndrome
  • Ranitidine 💊
  • Ranolazine 💊
  • Rapid Sequence Intubation (RSI)
  • Rapidly Progressive Glomerulonephritis (RPGN)
  • Rasagiline 💊
  • Rasburicase
  • Rate limiting steps in metabolism
  • Raynaud's Phenomenon Primary and Secondary
  • Reactive Arthritis
  • Rectal Foreign Body
  • Rectal Pain (Proctalgia)
  • Rectal Prolapse ✅
  • Rectal examination (OSCE)
  • Red Blood Cell Maturation
  • Red cell aplasia
  • Reduced/change in fetal movements
  • Refeeding syndrome
  • Referring to Level 2 or 3 care (ITU ICU HDU)
  • Reflex anoxic attacks in Children
  • Refractive Errors
  • Refsum disease
  • Regular Broad Complex Tachycardia ❤️
  • Rehabilitation in a Nutshell of older patients
  • Relapsing Polychondritis
  • Remdesvir (Veklury)
  • Renal Artery Stenosis Renovascular Disease
  • Renal Emergencies: Revision ✅
  • Renal Papillary Necrosis
  • Renal Replacement Therapy (RRT)
  • Renal Top Tips
  • Renal Transplantation
  • Renal Tubular Acidosis (RTA)
  • Renal Vein Thrombosis ✅
  • Renal cell carcinoma ✅
  • Renal syndromes
  • Renal: Basics
  • Renal: Chronic Kidney Disease
  • Renal: Dialysis and Transplant
  • Renal: Emergencies
  • Renal: Glomerular Disease
  • Renal: Tubular Inherited Stones (Complete)
  • Renin and Aldosterone Renin ratio (ARR)
  • Renin-angiotensin system
  • Respiratory Examination (OSCE)
  • Respiratory : Airways Disease
  • Respiratory : Interstitial Lung disease
  • Respiratory : Investigations
  • Respiratory : Lung Cancer
  • Respiratory Acidosis
  • Respiratory Alkalosis
  • Respiratory Arrest
  • Respiratory Crib Sheets
  • Respiratory Disease Investigations
  • Respiratory Distress Syndrome (Neonates)
  • Respiratory Emergencies: Revision✅
  • Respiratory Failure
  • Respiratory Revision Guide ✅
  • Respiratory Spirometry and Flow Volume Loops
  • Respiratory: Basics
  • Respiratory: Emergencies
  • Respiratory: Infections
  • Respiratory: Pulmonary Vascular Disease
  • Respiratory: Sleep and Breathing (Complete)
  • Restless legs syndrome
  • Restriction enzymes
  • Restrictive Cardiomyopathy
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  • Download the amazing global Makindo app: ✅ Means NICE/National Guidelines 2026 compliant Android | Apple
    MEDICAL DISCLAIMER: Educational use only. Not for diagnosis or management. See below for full disclaimer.

    Cardiology: History and Examination

    🩺 Cardiac history and examination — most cardiac diagnoses are made, or strongly suspected, from the history. The examination then confirms the likely problem, judges how severe it is, and looks for complications such as heart failure or endocarditis. This chapter covers each symptom, a step-by-step examination, how to recognise the common valve lesions, and how to present your findings.
    Your four questions for every patient: Is this cardiac, and is it dangerous right now? What is the likely cause (ischaemia, valve, rhythm, muscle, pericardium)? How severe is it — symptoms, signs of heart failure, complications? What are the risk factors and the impact on the person's life?


    Approach to the Cardiac History
    • Introduce yourself, confirm identity, gain consent, and ask open questions first ("Tell me what's been happening").
    • Presenting complaint — in the patient's words.
    • History of presenting complaint — explore each symptom (see below), then ask about the other key cardiac symptoms:
      • Chest pain or tightness.
      • Breathlessness — on exertion, lying flat (orthopnoea), waking at night (paroxysmal nocturnal dyspnoea).
      • Palpitations.
      • Dizziness, blackouts or falls.
      • Ankle swelling.
      • Fatigue and reduced exercise tolerance.
      • Calf pain on walking (claudication).
    • Systems review — fever and weight loss (endocarditis), cough and haemoptysis, symptoms of thyroid disease, anaemia, stroke or TIA.
    • Ideas, concerns and expectations — chest pain is frightening; ask what the patient thinks is going on.
    • Summarise back to the patient and check you've understood.

    💡 Clinical Pearl: For any symptom, ask "What can you do now that you could do before, and what stops you?" Exercise tolerance in real terms (stairs, distance to the shops) tells you more about severity than any scale.

    Chest Pain
    • Use SOCRATES — Site, Onset, Character, Radiation, Associations, Time course, Exacerbating and relieving factors, Severity.
    • Angina (cardiac ischaemia):
      • Central chest tightness, heaviness, pressure or a "band" (patients often deny "pain").
      • Radiates to the left arm, both arms, jaw, neck or back.
      • Brought on by exertion, emotion, cold or heavy meals; relieved by rest or GTN within about 5 minutes.
      • Typical angina (NICE CG95) has all three — constricting discomfort in the chest, neck, shoulders, jaw or arms; precipitated by exertion; relieved by rest or GTN within 5 minutes. Atypical — two of three. Non-anginal — one or none.
    • Acute coronary syndrome — similar pain but at rest, lasting over 15 minutes, or increasing in frequency or severity (unstable angina); with sweating, nausea, breathlessness, fear. Older people, women and people with diabetes may have atypical or no pain (breathlessness, collapse, confusion).
    • Other important causes:
      • Aortic dissection — sudden, tearing or ripping pain radiating to the back, maximal at onset; hypertension, Marfan syndrome.
      • Pericarditis — sharp central pain, worse lying flat and on breathing in, better sitting forward; recent viral illness.
      • Pulmonary embolism — pleuritic pain with sudden breathlessness, haemoptysis; risk factors for VTE.
      • Pneumothorax — sudden one-sided pleuritic pain and breathlessness.
      • Pneumonia — pleuritic pain, fever, productive cough.
      • Oesophageal — burning, related to meals or lying down, acid taste; oesophageal spasm can mimic angina and respond to GTN.
      • Musculoskeletal — localised, reproduced by pressing or moving; but tenderness doesn't exclude ACS.
      • Anxiety — with hyperventilation and tingling; a diagnosis of exclusion.
      • Shingles — burning dermatomal pain before the rash.

    ⚠️ Safety Pearl: Never let a "typical" musculoskeletal or indigestion story stop you from doing an ECG in someone with chest pain and risk factors. ACS, dissection and PE can all present atypically.

    Breathlessness
    • Onset and course — sudden (PE, pneumothorax, acute pulmonary oedema, arrhythmia), over days (pneumonia, decompensated heart failure), over months (chronic heart failure, valve disease, lung disease, anaemia).
    • Exertional breathlessness — how far can they walk on the flat, how many stairs?
    • Orthopnoea — breathless lying flat; ask "How many pillows do you sleep on, and why?" (pulmonary congestion — heart failure, but also severe COPD, obesity, diaphragm weakness).
    • Paroxysmal nocturnal dyspnoea — waking from sleep gasping, needing to sit up or go to a window; fairly specific for left heart failure.
    • Associated features — ankle swelling, weight gain (fluid), cough with pink frothy sputum (pulmonary oedema), wheeze ("cardiac asthma"), chest pain, palpitations, fatigue.
    • Non-cardiac causes — COPD, asthma, interstitial lung disease, anaemia, obesity and deconditioning, thyroid disease, anxiety, neuromuscular disease.
    • Grade it — NYHA class (see Grading Symptoms).
    Palpitations
    • Ask the patient to tap out the rhythm — fast and regular, fast and irregular, or "missed" or extra beats.
    • Key questions:
      • How do they start and stop — suddenly (re-entrant SVT, VT) or gradually (sinus tachycardia, anxiety)?
      • How long do they last, and how often?
      • Triggers — exercise (catecholaminergic arrhythmias, VT in cardiomyopathy), caffeine, alcohol ("holiday heart" AF), stress, standing up, lying on the left side (ectopics).
      • Terminating manoeuvres — breath-holding, straining or cold water stopping them suggests SVT.
      • Associated symptoms — chest pain, breathlessness, dizziness, syncope (red flag), polyuria afterwards (atrial stretch — SVT, AF).
    • Common patterns:
      • Ectopic beats — "missed beat then a thump", worse at rest and lying down; usually benign.
      • SVT — sudden onset of rapid regular palpitations in a young person, stopped by vagal manoeuvres.
      • AF — irregular, often with breathlessness or reduced exercise tolerance; older people, hypertension, alcohol, thyroid disease.
      • VT — fast palpitations with dizziness or collapse in someone with heart disease (previous MI, cardiomyopathy).
    • Ask about — thyroid symptoms, anaemia, caffeine, energy drinks, alcohol, recreational drugs (cocaine, amphetamines), medicines (salbutamol, levothyroxine, QT-prolonging drugs), family history of sudden death.
    Syncope and Dizziness
    • Syncope is transient loss of consciousness from reduced brain blood flow, with rapid, full recovery. Get an eyewitness account — what did they look like, how long, any jerking, colour?
    • Before — what were they doing (standing, exertion, turning the head, passing urine, coughing), any warning (light-headed, hot, nauseated, vision greying — vasovagal), palpitations or chest pain?
    • During — pale (cardiac or vasovagal), brief jerks are common in syncope; prolonged rhythmic jerking, tongue biting (side of tongue), and cyanosis suggest a seizure.
    • After — quick recovery suggests syncope; prolonged confusion suggests a seizure; injury suggests no warning (more worrying).
    • Patterns:
      • Vasovagal — triggers (standing, heat, pain, blood), prodrome, young people; benign.
      • Orthostatic — on standing; drugs, dehydration, autonomic failure; older people.
      • Situational — cough, micturition, defecation, swallowing.
      • Carotid sinus hypersensitivity — turning the head, shaving, tight collar; older people.
      • Cardiac — during exertion (aortic stenosis, HCM, arrhythmias), while lying down, with palpitations or chest pain, without warning, with known heart disease or a family history of sudden death.
    • Dizziness — distinguish light-headedness (presyncope — cardiovascular) from vertigo (spinning — vestibular) and unsteadiness (neurological).

    ⚠️ Safety Pearl: Collapse during exercise, collapse while lying down, or collapse with a family history of sudden death under 40 is cardiac until proven otherwise. Do an ECG and seek urgent cardiology advice.

    Swelling and Other Symptoms
    • Ankle swelling — both legs (heart failure, nephrotic syndrome, liver disease, drugs — amlodipine and other calcium channel blockers, NSAIDs, steroids, pregabalin) versus one leg (DVT, cellulitis, Baker's cyst, venous obstruction). Ask about weight gain (fluid), abdominal swelling (ascites), and swelling of the sacrum in bedbound patients.
    • Fatigue — common in heart failure and on beta-blockers; also anaemia, thyroid disease, depression, sleep apnoea.
    • Claudication — cramping calf, thigh or buttock pain on walking, relieved by rest within minutes; peripheral arterial disease (a marker of coronary disease). Rest pain at night relieved by hanging the leg down — critical limb ischaemia.
    • Fever, sweats and weight loss — think of infective endocarditis in anyone with a murmur, prosthetic valve, device or injecting drug use.
    • Cough and haemoptysis — pulmonary oedema (pink frothy sputum), mitral stenosis, PE.
    • Stroke or TIA symptoms — AF, endocarditis, PFO, LV thrombus.
    • Hoarse voice — rarely, an enlarged left atrium or aortic aneurysm compresses the left recurrent laryngeal nerve (Ortner's syndrome).
    Past, Drug, Family and Social History
    • Past medical history:
      • Previous MI, angina, stents (when, which vessel), CABG, valve surgery (mechanical or tissue valve), pacemaker or ICD, heart failure, AF, rheumatic fever in childhood, congenital heart disease.
      • Risk factors — hypertension, diabetes, high cholesterol, CKD, stroke or TIA, peripheral arterial disease.
      • Other — thyroid disease, sleep apnoea, autoimmune disease (SLE, rheumatoid arthritis), HIV, previous chemotherapy or chest radiotherapy (cardiotoxicity).
    • Drug history:
      • Cardiac drugs — and adherence.
      • Anticoagulants and antiplatelets (bleeding risk, procedures).
      • Drugs that cause or worsen heart problems — NSAIDs (heart failure, hypertension), steroids, calcium channel blockers (oedema), QT-prolonging drugs, thyroxine, decongestants, anthracyclines and trastuzumab.
      • Over-the-counter and herbal products; recreational drugs (cocaine, amphetamines, anabolic steroids).
      • Allergies — including contrast and aspirin.
    • Family history — premature coronary disease (a first-degree relative: men under 55, women under 65), sudden unexplained death under 40, cardiomyopathy, inherited arrhythmias, familial hypercholesterolaemia, aortic disease or dissection.
    • Social history:
      • Smoking (pack-years) and vaping; alcohol (units a week); recreational drugs.
      • Diet, physical activity, weight.
      • Occupation — driving (especially bus and lorry licences — DVLA rules), pilots, work involving heights or heavy machinery.
      • Home circumstances, stairs, carers, mobility and daily activities.
    Grading Symptoms
    ClassNYHA (heart failure breathlessness)CCS (angina)
    INo limitation of ordinary activityAngina only with strenuous or prolonged exertion
    IISlight limitation — symptoms with ordinary activity (e.g. hills, stairs)Slight limitation — walking fast, uphill, climbing stairs quickly
    IIIMarked limitation — symptoms with less than ordinary activity (e.g. walking on the flat)Marked limitation — walking 1–2 blocks or one flight of stairs at a normal pace
    IVSymptoms at rest or with any activityAngina with any physical activity, or at rest
    Preparing for the Examination
    • WIPER:
      • Wash your hands.
      • Introduce yourself and check identity.
      • Permission (consent) and offer a chaperone.
      • Expose the chest appropriately (preserve dignity — cover when not examining).
      • Reposition — sitting at 45 degrees, head supported, neck relaxed.
    • Ask about pain before touching.
    • Order — end of the bed, hands, pulses and BP, face and neck (JVP, carotids), precordium (inspect, palpate, auscultate), back of the chest, abdomen if relevant, legs.
    General Inspection
    • From the end of the bed — comfortable or distressed; breathless at rest or when undressing; colour (pallor, central cyanosis, flushed cheeks); sweating; body habitus (obesity, cachexia — "cardiac cachexia" in advanced heart failure).
    • Around the bed — oxygen, GTN spray, inhalers, fluid charts, urine bottles, mobility aids, a walking stick, IV lines, ECG monitor.
    • Scars — midline sternotomy (CABG or valve surgery), left lateral thoracotomy (mitral valvotomy, coarctation repair, PDA ligation), infraclavicular pacemaker or ICD scar, leg scars from vein harvest (CABG), groin or wrist puncture sites.
    • Syndromic features — Marfan syndrome (tall, long limbs — aortic root dilatation, mitral prolapse), Down syndrome (AVSD), Turner syndrome (coarctation, bicuspid valve), Noonan syndrome (pulmonary stenosis).
    • Audible click of a mechanical valve.
    Hands
    • Temperature — cool peripheries in low output states or shock; warm in high-output states.
    • Capillary refill — press the nail bed for 5 seconds; normal is under 2 seconds.
    • Peripheral cyanosis — blue fingers (poor perfusion, cold).
    • Clubbing — loss of the nail-bed angle (Schamroth's window test): cyanotic congenital heart disease, infective endocarditis, atrial myxoma, plus lung and gut causes.
    • Splinter haemorrhages — endocarditis (also trauma — more than a few is significant).
    • Janeway lesions (painless red macules on the palms) and Osler's nodes (painful nodules on the finger pulps) — endocarditis.
    • Tendon xanthomas (knuckles, Achilles) — familial hypercholesterolaemia.
    • Nicotine staining — smoking.
    • Koilonychia or pale palmar creases — anaemia.
    • Arachnodactyly (long fingers) — Marfan syndrome.
    • Tremor, sweaty palms — thyrotoxicosis (AF, high-output state).
    Pulse
    • Radial pulse — rate (count for 30 seconds, or a full minute if irregular) and rhythm:
      • Regular.
      • Regularly irregular — sinus arrhythmia (varies with breathing), second-degree heart block, regular ectopics (bigeminy).
      • Irregularly irregular — AF (or frequent ectopics). In AF the apex rate can exceed the radial rate (pulse deficit).
    • Radio-radial delay or different volumes — subclavian stenosis, aortic dissection, coarctation (proximal to the left subclavian).
    • Radio-femoral delay — coarctation of the aorta (check in young people with hypertension).
    • Collapsing pulse — feel the radial with your palm and raise the arm (after checking for shoulder pain): a forceful tapping pulse that quickly falls away — aortic regurgitation, PDA, high-output states (anaemia, thyrotoxicosis, pregnancy, AV fistula).
    • Carotid pulse — assess the character and volume (one side at a time; listen for a bruit first):
      • Slow-rising, low-volume — aortic stenosis.
      • Bisferiens (two peaks) — mixed aortic valve disease, HCM.
      • Jerky — HCM.
      • Small volume — low cardiac output, shock.
      • Bounding — CO2 retention, sepsis, high-output states.
      • Pulsus alternans — strong and weak beats alternating — severe LV failure.
      • Pulsus paradoxus — the pulse weakens on breathing in (systolic fall over 10 mmHg) — cardiac tamponade, severe asthma or COPD, constriction.
    Blood Pressure
    • Measure BP (both arms at first assessment); a difference over 15 mmHg is abnormal (subclavian stenosis, dissection, coarctation).
    • Wide pulse pressure (systolic minus diastolic, e.g. 170/40) — aortic regurgitation, high-output states, stiff arteries in older people.
    • Narrow pulse pressure — severe aortic stenosis, tamponade, low cardiac output.
    • Lying and standing BP — in falls, syncope and dizziness (orthostatic hypotension: fall of 20 mmHg systolic or 10 diastolic within 3 minutes).
    • Technique and thresholds are covered in the Cardiac Investigations chapter.
    Face, Eyes and Mouth
    • Eyes:
      • Conjunctival pallor — anaemia.
      • Xanthelasma (yellow eyelid plaques) and corneal arcus under 50 — hyperlipidaemia.
      • Conjunctival petechiae and Roth spots (retinal haemorrhages with pale centres on fundoscopy) — endocarditis.
      • Hypertensive retinopathy on fundoscopy.
      • Lens dislocation (upward) — Marfan syndrome.
    • Face — malar flush (purple-red cheeks — mitral stenosis, low output), puffy face (hypothyroidism), signs of thyroid eye disease.
    • Mouth — central cyanosis (blue tongue and lips — right-to-left shunt, severe lung disease), dental hygiene (endocarditis source), high-arched palate (Marfan syndrome), dehydration.
    Jugular Venous Pressure
    • What it shows: The pressure in the right atrium — a window on the right side of the heart and fluid status.
    • How to assess:
      • Patient at 45 degrees, head turned slightly to the left, neck relaxed.
      • Look for the pulsation of the internal jugular vein between the two heads of sternocleidomastoid, rising towards the earlobe.
      • Measure the vertical height of the top of the pulsation above the sternal angle — normal is under 3–4 cm.
    • Venous or arterial? The JVP:
      • Has a double waveform (two peaks per heartbeat — "a" and "v" waves).
      • Is not palpable and can be occluded by gentle pressure at the base of the neck.
      • Changes with position (rises lying flat, falls sitting up) and with breathing (falls on inspiration).
      • Rises with abdominal pressure (hepatojugular reflux — a sustained rise suggests right heart failure).
    • Raised JVP — right heart failure, fluid overload, tricuspid regurgitation, PE, pulmonary hypertension, tamponade, constrictive pericarditis. Fixed, raised and non-pulsatile — superior vena cava obstruction.
    • Waveform abnormalities:
      • Large "v" waves — tricuspid regurgitation (may pulse the earlobes).
      • Cannon "a" waves — atria contracting against a closed tricuspid valve: complete heart block (irregular cannon waves), VT.
      • Absent "a" waves — AF.
      • Kussmaul's sign (JVP rises on inspiration) — constrictive pericarditis, restrictive cardiomyopathy, RV infarction, tamponade (less often).
    • Low JVP (not visible lying flat) — dehydration, hypovolaemia.
    Precordium — Inspection and Palpation
    • Inspect — scars, pacemaker or ICD box, chest wall deformity (pectus excavatum, carinatum — Marfan syndrome), visible apex pulsation.
    • Apex beat — the lowest and most lateral point where the pulsation is felt; normally the 5th intercostal space, mid-clavicular line.
      • Displaced (laterally or downwards) — LV dilatation (heart failure, mitral or aortic regurgitation, dilated cardiomyopathy). Also shifted by chest wall deformity, pneumothorax, effusion or lung collapse.
      • Heaving (forceful, sustained) — pressure overload with LV hypertrophy: aortic stenosis, hypertension, HCM.
      • Thrusting (forceful, not sustained, displaced) — volume overload: aortic or mitral regurgitation.
      • Tapping — palpable first heart sound — mitral stenosis.
      • Double impulse — HCM.
      • Impalpable — obesity, emphysema, pericardial effusion, dextrocardia (check the right side).
    • Parasternal heave — place the heel of your hand left of the sternum; a lift suggests RV hypertrophy (pulmonary hypertension, pulmonary stenosis, mitral stenosis) or a large left atrium.
    • Thrills — palpable murmurs (grade 4 or more) — feel over each valve area with your palm. For example, aortic stenosis (aortic area), VSD (left sternal edge).
    Heart Sounds
    • Auscultation areas (listen with the diaphragm, then the bell):
      • Mitral — apex (5th intercostal space, mid-clavicular line).
      • Tricuspid — lower left sternal edge (4th–5th intercostal space).
      • Pulmonary — 2nd intercostal space, left sternal edge.
      • Aortic — 2nd intercostal space, right sternal edge.
    • Time sounds against the carotid pulse — S1 is just before the pulse; S2 just after.
    • First heart sound (S1) — closure of the mitral and tricuspid valves:
      • Loud — mitral stenosis, tachycardia, short PR.
      • Soft — mitral regurgitation, long PR, poor LV function.
      • Variable — AF, complete heart block.
    • Second heart sound (S2) — closure of the aortic (A2) and pulmonary (P2) valves:
      • Soft or absent A2 — severe aortic stenosis.
      • Loud P2 — pulmonary hypertension.
      • Normal splitting — widens on inspiration.
      • Wide splitting — RBBB, pulmonary stenosis.
      • Fixed splitting (doesn't change with breathing) — ASD.
      • Reversed splitting (splits on expiration) — LBBB, severe aortic stenosis.
    • Prosthetic valves — mechanical valves produce a crisp metallic click (opening and closing); loss of the click suggests valve thrombosis — an emergency.
    Murmurs
    • Describe a murmur systematically:
      • Timing — systolic (with the pulse) or diastolic; ejection (crescendo–decrescendo) or pansystolic.
      • Site where loudest.
      • Radiation — to the carotids (aortic stenosis), axilla (mitral regurgitation).
      • Grade (Levine, out of 6) — 1 barely audible; 2 soft; 3 moderate, no thrill; 4 loud with a thrill; 5 heard with the stethoscope edge on the chest; 6 heard with the stethoscope off the chest.
      • Pitch and quality — harsh, blowing, rumbling.
      • Effect of manoeuvres (below).
    • Manoeuvres:
      • Left lateral position, breath out, listen at the apex with the bell — mitral stenosis (low-pitched mid-diastolic rumble).
      • Sitting forward, breath held in expiration, listen at the left sternal edge with the diaphragm — aortic regurgitation (early diastolic murmur).
      • Inspiration makes right-sided murmurs louder; expiration makes left-sided murmurs louder.
      • Valsalva or standing makes the murmurs of HCM and mitral valve prolapse louder (other murmurs get quieter); squatting does the opposite.
    • Systolic murmurs:
      • Ejection systolic — aortic stenosis, aortic sclerosis (no radiation, normal pulse), pulmonary stenosis, HCM, ASD (flow), innocent flow murmurs (pregnancy, anaemia, fever, children).
      • Pansystolic — mitral regurgitation (apex to axilla), tricuspid regurgitation (left sternal edge, louder on inspiration, large v waves), VSD (left sternal edge, often loud with a thrill).
      • Late systolic — mitral valve prolapse (after a mid-systolic click).
    • Diastolic murmurs — always pathological:
      • Early diastolic — aortic regurgitation, pulmonary regurgitation (Graham Steell murmur in pulmonary hypertension).
      • Mid-diastolic — mitral stenosis, Austin Flint murmur (severe aortic regurgitation), atrial myxoma.
    • Continuous — PDA ("machinery" murmur under the left clavicle), AV fistula; venous hum in children (disappears lying down).
    • Innocent murmurs — soft (grade 1–2), systolic, short, no radiation, normal heart sounds, no symptoms, normal ECG; anything else needs an echo.
    Added Sounds
    • Third heart sound (S3) — early diastole, low-pitched ("Ken-tuck-y"); rapid ventricular filling: heart failure, mitral regurgitation; can be normal in young people, athletes and pregnancy.
    • Fourth heart sound (S4) — late diastole, before S1 ("Ten-nes-see"); atria pushing into a stiff ventricle: LVH, hypertension, aortic stenosis, HCM, acute MI. Never heard in AF (no atrial contraction).
    • Gallop rhythm — S3 or S4 with tachycardia.
    • Opening snap — early diastole, high-pitched, after S2 — mitral stenosis (pliable valve).
    • Ejection click — early systole — bicuspid aortic valve, pulmonary stenosis.
    • Mid-systolic click — mitral valve prolapse.
    • Pericardial rub — scratchy, "creaking leather" sound, best sitting forward — pericarditis (may come and go).
    • Pericardial knock — early diastolic — constrictive pericarditis.
    • Tumour plop — rare — left atrial myxoma.
    Lungs, Abdomen and Legs
    • Lung bases (sit the patient forward) — fine inspiratory crackles (pulmonary oedema), dullness and reduced breath sounds (pleural effusions — often bilateral in heart failure), wheeze.
    • Sacral oedema — check in people lying in bed (fluid collects at the lowest point).
    • Abdomen (if relevant) — tender, enlarged liver (congestion), pulsatile liver (severe tricuspid regurgitation), ascites, splenomegaly (endocarditis), abdominal aortic aneurysm (expansile pulsatile mass), renal bruits.
    • Legs:
      • Pitting oedema — press for 10 seconds; note how far up it goes (ankles, shins, knees, thighs).
      • Peripheral pulses (femoral, popliteal, posterior tibial, dorsalis pedis).
      • Vein harvest scars (CABG), varicose veins, signs of DVT, skin changes of arterial or venous disease, ulcers.
    Peripheral Vascular Examination
    • Inspect — colour (pale, dusky, mottled), hair loss, shiny skin, ulcers (arterial — toes, heels, punched out; venous — gaiter area), gangrene, amputations, scars from bypass surgery.
    • Palpate — temperature (compare both sides), capillary refill, all pulses (radial, brachial, carotid, femoral, popliteal, posterior tibial, dorsalis pedis), abdominal aorta.
    • Auscultate — bruits over the carotids, abdominal aorta, renal arteries, femoral arteries.
    • Buerger's test — raise the leg: pallor at a low angle (under 20 degrees) suggests severe ischaemia; then hang it down — slow reddening ("sunset foot") confirms it.
    • ABPI — ankle–brachial pressure index with a Doppler: 0.9–1.3 normal; under 0.9 peripheral arterial disease; under 0.5 severe; over 1.3 calcified arteries (diabetes, CKD).
    • Acute limb ischaemia — the 6 Ps: Pain, Pallor, Pulselessness, Perishing cold, Paraesthesia, Paralysis — a vascular emergency.
    Completing and Presenting
    • To complete the examination, say you would:
      • Check observations (heart rate, BP lying and standing, respiratory rate, oxygen saturations, temperature).
      • Do a 12-lead ECG.
      • Fundoscopy (hypertension, endocarditis).
      • Urine dipstick (haematuria in endocarditis, proteinuria in hypertension).
      • Peripheral vascular examination if relevant.
      • Arrange tests — echo, chest X-ray, bloods (see the Cardiac Investigations chapter).
    • Thank the patient, help them dress, wash your hands.
    • Presenting — a clear structure:
      • "Mr X is a 72-year-old man who is comfortable at rest."
      • Positive findings first — "He has a slow-rising, low-volume pulse, a narrow pulse pressure, a heaving, undisplaced apex, and a harsh grade 3 ejection systolic murmur loudest at the aortic area radiating to the carotids, with a soft second heart sound."
      • Relevant negatives — "There are no signs of heart failure or endocarditis."
      • Summary and diagnosis — "These findings are consistent with severe aortic stenosis."
      • Differential, severity, cause and complications — "Signs of severity are... The likely cause at his age is calcific degeneration."
      • Next steps — "I would like to do an ECG and arrange an echocardiogram."

    💡 Clinical Pearl: When presenting a murmur, always add the four things examiners want: the likely lesion, signs of severity, the likely cause, and any complications (heart failure, AF, endocarditis).

    Signs of Heart Failure
    • Left-sided (pulmonary congestion) — breathlessness, orthopnoea, PND; tachypnoea, bibasal fine crackles, pleural effusions, S3 gallop, displaced apex, pulsus alternans in severe disease.
    • Right-sided (systemic congestion) — raised JVP, positive hepatojugular reflux, peripheral pitting oedema, sacral oedema, tender hepatomegaly, ascites, weight gain.
    • Low output — cool peripheries, prolonged capillary refill, low BP, narrow pulse pressure, confusion, oliguria.
    • Look for the cause — previous MI (scars, Q waves), valve disease (murmur), AF, hypertension, alcohol, thyroid disease, cardiomyopathy.
    • Warm/cold and wet/dry — a quick bedside way to classify acute heart failure: "warm and wet" (congested, perfused — diuretics), "cold and wet" (congested, poorly perfused — cardiogenic shock).
    Valve Lesions at a Glance
    LesionKey signsSigns of severity
    Aortic stenosisSlow-rising pulse; heaving undisplaced apex; harsh ejection systolic murmur, aortic area, radiating to the carotids; ejection click if bicuspidNarrow pulse pressure; soft or absent S2; late-peaking murmur; S4; reversed splitting; LV failure; symptoms (angina, syncope, breathlessness)
    Aortic sclerosisEjection systolic murmur in an older personNormal pulse, normal S2, no radiation — benign but a marker of cardiovascular risk
    Aortic regurgitationCollapsing pulse; wide pulse pressure; displaced, thrusting apex; early diastolic murmur at the left sternal edge (sitting forward, in expiration)Very wide pulse pressure; Austin Flint mid-diastolic murmur; heart failure; eponymous signs (de Musset's head nodding, Quincke's nail bed pulsation, Corrigan's visible carotid pulse)
    Mitral stenosisMalar flush; AF; tapping apex; loud S1; opening snap; mid-diastolic rumble at the apex (bell, left lateral position)Opening snap closer to S2; longer murmur; signs of pulmonary hypertension (loud P2, parasternal heave)
    Mitral regurgitationDisplaced, thrusting apex; soft S1; pansystolic murmur at the apex radiating to the axilla; S3Displaced apex; S3; signs of heart failure; AF; pulmonary hypertension
    Mitral valve prolapseMid-systolic click then a late systolic murmur; louder on standing or ValsalvaProgression to pansystolic murmur (more regurgitation)
    Tricuspid regurgitationLarge v waves in the JVP; pulsatile liver; pansystolic murmur at the lower left sternal edge, louder on inspirationAscites, oedema; usually secondary to pulmonary hypertension or a dilated RV; IV drug users (endocarditis)
    Pulmonary stenosisEjection systolic murmur at the pulmonary area, louder on inspiration; ejection clickParasternal heave; soft P2; Noonan syndrome
    VSDLoud, harsh pansystolic murmur at the left sternal edge, often with a thrillSmaller defects are louder; Eisenmenger syndrome (cyanosis, clubbing) if untreated
    ASDFixed split S2; soft ejection systolic flow murmur at the pulmonary areaParasternal heave; AF; signs of pulmonary hypertension
    HCMJerky pulse; double apical impulse; ejection systolic murmur at the left sternal edge, louder on standing or Valsalva; S4Family history of sudden death; syncope; heart failure
    PDAContinuous "machinery" murmur under the left clavicle; collapsing pulseEisenmenger syndrome (differential cyanosis — blue toes, pink fingers)
    Signs of Endocarditis
    • Suspect in anyone with fever and a murmur (new or changed), especially with a prosthetic valve, device, previous endocarditis, congenital heart disease or injecting drug use.
    • Signs:
      • Fever, malaise, weight loss.
      • Murmur — new regurgitant murmur (valve destruction).
      • Hands — splinter haemorrhages, Janeway lesions, Osler's nodes, clubbing (subacute).
      • Eyes — conjunctival petechiae, Roth spots.
      • Splenomegaly.
      • Microscopic haematuria (glomerulonephritis or emboli).
      • Embolic events — stroke, limb ischaemia, septic pulmonary emboli (right-sided endocarditis).
      • Heart failure (valve destruction), new heart block (aortic root abscess).
    • Next steps — three sets of blood cultures from different sites before antibiotics (if stable), urgent echo (TTE then TOE), urine dipstick, ECG (PR prolongation); see the Pericardial Disease and Endocarditis chapter.
    Special Situations
    • Cardiac tamponade — Beck's triad: low BP, raised JVP, muffled heart sounds; plus tachycardia and pulsus paradoxus — urgent echo and pericardiocentesis.
    • Aortic dissection — tearing pain to the back, unequal arm pulses or BP (difference over 20 mmHg), new early diastolic murmur (aortic regurgitation), neurological deficit — urgent CT aorta.
    • Cardiogenic shock — hypotension, cold clammy peripheries, confusion, oliguria, pulmonary oedema.
    • Constrictive pericarditis — raised JVP with Kussmaul's sign, pericardial knock, ascites and oedema out of proportion, hepatomegaly; previous TB, radiotherapy or cardiac surgery.
    • Pregnancy — normal findings include a faster heart rate, a soft ejection systolic flow murmur, an S3, mild ankle oedema and lower BP in mid-pregnancy; diastolic murmurs and severe breathlessness are abnormal.
    • Older people — aortic sclerosis is common; symptoms are often atypical (falls, confusion, fatigue); check lying and standing BP; review medications.
    • Children — innocent murmurs are very common (Still's murmur, venous hum); check femoral pulses (coarctation) and look for signs of heart failure (poor feeding, sweating, faltering growth) — see the Paediatric Respiratory and Cardiac chapter.
    Signs at a Glance
    SignThink of
    Slow-rising pulse, narrow pulse pressureAortic stenosis
    Collapsing pulse, wide pulse pressureAortic regurgitation (or high-output state)
    Irregularly irregular pulseAtrial fibrillation
    Radio-femoral delayCoarctation of the aorta
    Pulsus paradoxusCardiac tamponade, severe asthma
    Pulsus alternansSevere LV failure
    Raised, non-pulsatile JVPSVC obstruction
    Large v waves, pulsatile liverTricuspid regurgitation
    Cannon a wavesComplete heart block, VT
    Kussmaul's signConstrictive pericarditis, restrictive cardiomyopathy, RV infarction
    Malar flushMitral stenosis
    Tapping apex, loud S1, opening snapMitral stenosis
    Heaving, undisplaced apexLV hypertrophy (aortic stenosis, hypertension, HCM)
    Displaced, thrusting apexLV dilatation (mitral or aortic regurgitation, cardiomyopathy)
    Parasternal heave, loud P2Pulmonary hypertension
    Fixed split S2Atrial septal defect
    Reversed split S2LBBB, severe aortic stenosis
    S3Heart failure (normal in young people and pregnancy)
    S4Stiff LV (hypertension, aortic stenosis, HCM) — never in AF
    Mid-systolic click then late systolic murmurMitral valve prolapse
    Murmur louder on Valsalva or standingHCM or mitral valve prolapse
    Continuous machinery murmurPatent ductus arteriosus
    Pericardial rub, best sitting forwardPericarditis
    Splinter haemorrhages, Osler's nodes, Janeway lesions, Roth spotsInfective endocarditis
    Tendon xanthomas, corneal arcus under 50Familial hypercholesterolaemia
    Loss of mechanical valve clickValve thrombosis — emergency
    Spot the Diagnosis
    ClueDiagnosis
    Central chest tightness on exertion relieved by rest within 5 minutesTypical angina
    Sudden tearing chest pain to the back with unequal arm BPsAortic dissection
    Sharp chest pain, worse lying flat, better sitting forward, with a scratchy soundAcute pericarditis
    Wakes at night gasping, sleeps on four pillows, swollen anklesLeft and right heart failure
    Sudden regular fast palpitations stopped by blowing into a syringeSVT
    Collapse while running in a 19-year-old whose uncle died suddenlyHCM or inherited arrhythmia
    Collapse on standing from bed in a man on tamsulosinOrthostatic hypotension
    Ankle swelling after starting amlodipineCalcium channel blocker oedema
    Midline sternotomy and a vein harvest scar on the legPrevious CABG
    Sternotomy with a metallic click on auscultationMechanical valve replacement
    Tall man with long fingers, high-arched palate and early diastolic murmurMarfan syndrome with aortic regurgitation
    Young hypertensive woman with radio-femoral delayCoarctation of the aorta
    Malar flush, AF, loud S1, mid-diastolic murmur at the apexMitral stenosis
    Pansystolic murmur at the apex radiating to the axillaMitral regurgitation
    Ejection systolic murmur in an 85-year-old with normal pulse and S2, no radiationAortic sclerosis
    Low BP, raised JVP, quiet heart sounds after chest traumaCardiac tamponade (Beck's triad)
    Fever, new murmur and splinter haemorrhages in an injecting drug userInfective endocarditis
    Murmur that gets louder when the patient stands up from squattingHCM
    Exam-style Scenarios

    1. A 74-year-old man has become breathless on exertion and fainted twice while walking uphill. His pulse is slow-rising, BP 118/86, apex undisplaced and heaving, with a harsh ejection systolic murmur radiating to the carotids and a quiet S2.
    Answer: Severe aortic stenosis (symptomatic).

    • Severity signs — slow-rising pulse, narrow pulse pressure, soft S2, exertional syncope.
    • Likely cause — calcific degeneration (bicuspid valve in younger people).
    • Next — ECG, urgent echo, cardiology referral for valve replacement (TAVI or surgery); no exercise testing.

    2. A 55-year-old woman has a collapsing pulse, BP 168/48, a displaced thrusting apex and an early diastolic murmur at the left sternal edge, loudest sitting forward in expiration.
    Answer: Aortic regurgitation.

    • Severity — very wide pulse pressure, displaced apex, Austin Flint murmur, heart failure.
    • Causes — aortic root dilatation (hypertension, Marfan syndrome), bicuspid valve, endocarditis, rheumatic disease, dissection (acute).
    • Next — echo; look for endocarditis signs; check for Marfan features.

    3. A 68-year-old woman originally from Bangladesh has an irregularly irregular pulse, malar flush, a tapping apex, a loud S1 and a low rumbling mid-diastolic murmur at the apex, heard best with the bell in the left lateral position.
    Answer: Mitral stenosis with AF (likely rheumatic).

    • Severity — opening snap close to S2, long murmur, signs of pulmonary hypertension.
    • Complications — AF, stroke (anticoagulation with warfarin in moderate–severe mitral stenosis), pulmonary hypertension.
    • Next — ECG, echo; anticoagulation; consider valvotomy or replacement.

    4. A 70-year-old man with breathlessness has a raised JVP at 8 cm, bibasal crackles, pitting oedema to the knees, a displaced apex and a gallop rhythm.
    Answer: Congestive (left and right) heart failure.

    • Look for the cause — previous MI, valve disease, AF, hypertension, alcohol.
    • Next — ECG, NT-proBNP, chest X-ray, bloods, echo.
    • Treat congestion with loop diuretics; monitor weight and kidney function.

    5. A 32-year-old man who injects heroin has a fever of 39 °C, a pansystolic murmur at the left lower sternal edge that is louder on inspiration, and large v waves in the JVP.
    Answer: Right-sided (tricuspid) infective endocarditis.

    • Three sets of blood cultures before antibiotics; urgent echo (TTE, then TOE if needed).
    • Chest X-ray (septic pulmonary emboli); urine dipstick; ECG.
    • Empirical antibiotics per local endocarditis protocol; Staph aureus is the commonest organism; harm reduction and BBV testing.
    Key Points
    • The history makes most cardiac diagnoses: chest pain, breathlessness, palpitations, syncope, swelling.
    • Typical angina: constricting chest discomfort, brought on by exertion, relieved by rest or GTN within 5 minutes.
    • Exertional syncope, syncope lying down, or a family history of sudden death under 40 — cardiac until proven otherwise.
    • Ask palpitating patients to tap out the rhythm; sudden onset and offset suggests SVT.
    • Grade breathlessness with NYHA and angina with CCS.
    • Examine in order: end of bed, hands, pulse, BP, face, JVP, precordium, back, legs.
    • JVP: double waveform, non-palpable, occludable, varies with position and breathing; normal under 3–4 cm above the sternal angle.
    • Apex: heaving (pressure overload) versus displaced and thrusting (volume overload).
    • Time murmurs against the carotid pulse; grade them out of 6 (grade 4 has a thrill).
    • Mitral stenosis — bell, left lateral, expiration; aortic regurgitation — diaphragm, sitting forward, expiration.
    • Diastolic murmurs are always pathological.
    • Aortic stenosis severity: slow-rising pulse, narrow pulse pressure, soft S2, late-peaking murmur, symptoms.
    • HCM and mitral prolapse murmurs get louder on standing or Valsalva.
    • Fever plus a murmur — think endocarditis: blood cultures before antibiotics.
    • Beck's triad (low BP, raised JVP, quiet heart sounds) — tamponade.
    • Present positive findings, relevant negatives, diagnosis, severity, cause, complications and next steps.
    Guidelines and Further Reading
    • NICE CG95: Recent-onset chest pain of suspected cardiac origin
    • NICE CG109: Transient loss of consciousness ("blackouts") in over 16s
    • NICE NG106: Chronic heart failure in adults
    • ESC/EACTS Guidelines for the management of valvular heart disease
    • ESC Guidelines for the management of endocarditis
    • DVLA: Assessing fitness to drive — cardiovascular disorders
    • Geeky Medics and BMJ OSCE resources: Cardiovascular examination
    • BNF — for current doses

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