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Pabrinex
⚠️ Important: Always give Pabrinex/Thiamine before glucose (IV/PO). Giving glucose first can precipitate Wernicke’s encephalopathy in deficient patients. Be prepared to manage anaphylaxis — resuscitation facilities must be available. If not available consider in high patients IV Thiamine 400 mg three times daily for 3 days should be prescribed and should be given by infusion over 30 minutes.
💊 About
- Check the BNF here before prescribing.
- Pabrinex provides rapid replacement of thiamine (B1) and other essential water-soluble vitamins.
- Used in acute deficiency states, especially in high-risk groups such as alcohol dependence and severe malnutrition.
🎯 Indications
- Suspected or proven thiamine deficiency.
- Alcohol dependence (prevention of Wernicke–Korsakoff syndrome).
- Malnutrition, prolonged poor dietary intake, or refeeding risk.
- Hyperemesis gravidarum.
- Beriberi and other B-vitamin deficiency states.
💉 Dosing (Typical Adult Regimens)
- Prophylaxis in at-risk patients: Pabrinex IV/IM once daily for 3–5 days, then switch to oral thiamine 100 mg TDS.
- Suspected Wernicke’s encephalopathy: Pabrinex 2 pairs of vials IV TDS for at least 3–5 days. Continue oral thiamine afterwards.
- Administration: Dilute 1 ampoule of No. 1 + 1 ampoule of No. 2 in 100 mL NS or 5% glucose. Infuse over 30 minutes, then flush with 100 mL NS/5% glucose.
⚠️ Side Effects
- Anaphylaxis (rare but potentially life-threatening) — always give in a monitored setting.
- Other reactions: flushing, rash, wheeze, urticaria.
💉 Composition
- Ampoule No. 1 (5–10 mL): Thiamine 250–500 mg, Riboflavin 4–8 mg, Pyridoxine 50–100 mg.
- Ampoule No. 2 (5–10 mL): Ascorbic acid 500–1000 mg, Nicotinamide 160–320 mg, Glucose 1000–2000 mg.
📚 References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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