Makindo Medical Notes"One small step for man, one large step for Makindo" |
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🚨 Emergency tip: Always consider urgent Prothrombin Complex Concentrate (PCC) for any intracranial bleed on Warfarin with INR >1.5. 👉 Always give with IV Vitamin K. Seek urgent haematology advice.
Always check the BNF link here.
| Indication | Details |
|---|---|
| 🩸 Warfarin / VKA Reversal |
PCC
• INR 2–6 → 25 units/kg IV • INR >6 → 50 units/kg IV • Always give with Vitamin K 5 mg IV |
| 🧠 Intracerebral Bleed (Warfarin / Xa inhibitors) |
PCC 50 units/kg IV stat (max 3,000 units)
⚠️ Do not delay for INR result |
| 💉 Administration |
• Slow IV infusion via syringe pump
• Start 1 mL/min → increase to max 3 mL/min as tolerated • Infusion may take ~30 min 🔄 Re-check INR at 6 h and re-dose only on haematology advice |