Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Herpes Varicella-Zoster (Shingles) Infection |Chickenpox Varicella Infection |Varicella Cerebral Vasculopathy |Herpes Viruses |Herpes Zoster Ophthalmicus (HZO) Shingles |MonkeyPox |Mumps |Measles |Rubella (German Measles) |Epstein-Barr Virus infection |Cytomegalovirus (CMV) infections |CMV retinitis infections |Toxoplasmosis
💊 Aciclovir is a life-saving antiviral that treats HSV-1, HSV-2, and Varicella-Zoster. ❌ It is not active against CMV (→ use Ganciclovir instead). ⚠️ Only activated inside infected cells (via viral thymidine kinase), giving it high selectivity.
Indication | Typical Dose |
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🧠 Herpes Simplex Encephalitis | 10 mg/kg IV every 8 hrs for 14–21 days (1 hr infusion) |
🌸 Mild/Moderate Oral or Genital HSV | 200 mg PO 5×/day for 5 days OR 400 mg PO TDS for 3–5 days OR 800 mg PO TDS for 2 days |
🔥 Severe Genital HSV | 5–10 mg/kg IV every 8 hrs for 5 days (1 hr infusion) |
🦠 Varicella Zoster (Shingles/Severe Chickenpox) | 800 mg PO 5×/day for 7 days OR 10 mg/kg IV every 8 hrs for 10–14 days if CNS involved |