Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |OSCE Eye Exam |OSCE Ear Exam |OSCE Abdominal Exam |OSCE Ascites Exam |OSCE Jaundice Exam |OSCE Testicular Exam |OSCE Inguinal Exam |OSCE Upper limb Neurology |OSCE Lower limb Neurology |OSCE Face Neurology
π‘ Clinical Pearl: Always be ready to suggest differentials and investigations. First-line tests π LFTs, bilirubin, FBC. Imaging π Abdominal ultrasound. In older patients with pronounced jaundice: β Painful jaundice β gallstone in CBD (choledocholithiasis). β Painless jaundice β cancer of head of pancreas (classic exam favourite). π οΈ Management: ERCP for stone removal or stenting for obstruction.
Category | Cause | Mechanism | Key Features |
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Pre-hepatic | Haemolytic Anaemia | β RBC breakdown β unconjugated bilirubin | Anaemia, dark urine, splenomegaly, β reticulocytes |
Hepatic | Viral Hepatitis | Hepatocyte injury β impaired conjugation | RUQ pain, malaise, jaundice, β ALT/AST |
Alcoholic Hepatitis | Alcohol-induced hepatocellular damage | Tender hepatomegaly, AST:ALT > 2, jaundice | |
Drug-Induced | Medication hepatotoxicity | Jaundice + systemic features, temporal drug link | |
Gilbertβs Syndrome | UGT deficiency β mild unconjugated rise | Intermittent jaundice triggered by stress/fasting | |
Post-hepatic | Choledocholithiasis | CBD obstruction by gallstone | Dark urine, pale stools, pruritus, biliary colic |
Pancreatic Ca (Head) | Tumour compressing CBD | Painless jaundice, weight loss, Courvoisierβs sign | |
Cholangiocarcinoma | Bile duct malignancy | Progressive jaundice, itching, pale stools |