Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Assesment of the Causes of Breast tenderness/pain (Mastalgia) |BRCA genes (Familial Breast Cancer) |Breast Anatomy and Examination (OSCE) |Breast Cancer |Breast Fibroadenoma |Breast Lumps: Clinical Approach and Considerations |Mastitis and breast abscess
| Category | Key Points |
|---|---|
| 𧬠Genetic | BRCA1/2, TP53, PTEN mutations β impaired DNA repair |
| βοΈ Reproductive / Hormonal | Early menarche, late menopause, nulliparity, HRT β prolonged oestrogen exposure |
| π· Lifestyle | Obesity, alcohol, smoking, sedentary habits β β oestrogen, oxidative stress |
| β’οΈ Radiation | Chest irradiation <30 yrs (e.g. Hodgkinβs therapy) β DNA breaks |
| π‘οΈ Protective | Breastfeeding, exercise, healthy diet β β lifetime oestrogen exposure |
Teaching Pearl: Only 5β10% are hereditary (BRCA carriers); most are sporadic.
| Condition | Typical Features |
|---|---|
| Fibroadenoma | Young women, firm, mobile βbreast mouseβ |
| Breast cyst | Smooth, fluctuant, cyclical changes |
| Fibrocystic disease | Lumpy, rope-like, worse premenstrually |
| Mastitis / Abscess | Painful, erythematous, lactation-related |
| Fat necrosis | Post-trauma, irregular, mimics cancer |
| Subtype | Features |
|---|---|
| Luminal A | ER+/PR+, HER2β, low Ki-67 β most common; good prognosis; endocrine therapy works well |
| Luminal B | ER+, often HER2+, high Ki-67 β more aggressive; needs endocrine Β± chemo Β± HER2 therapy |
| HER2-Enriched | ERβ/PRβ/HER2+ β aggressive but responds to trastuzumab/pertuzumab |
| Triple-Negative (TNBC) | ERβ/PRβ/HER2β β common in young/BRCA1; poor prognosis but chemo-sensitive |