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Neutrophil Alkaline Phosphatase
Related Subjects: |Neutropenia |Neutrophils |Ferritin |CEA |ESR |CRP |ALP |LDH |HbA1c |Alpha Fetoprotein |Neutrophil Alkaline Phosphatase |Anti-Hu ab |Anti-Yo ab |Anti-SCL70 ab |Prolactin |Liver Function Tests |Biochemical Lab values
About Neutrophil Alkaline Phosphatase (NAP)
- Neutrophil (Leukocyte) Alkaline Phosphatase (NAP): An enzyme found in neutrophils that reflects their functional state.
- Diagnostic Use: Previously used as a diagnostic marker, but its role has largely been replaced by flow cytometry and more advanced hematologic tests.
Causes of Elevated NAP Levels
- Polycythaemia Rubra Vera: Elevated NAP is a common finding.
- Leukaemoid Reaction: A benign, reactive increase in white blood cells often due to infection or inflammation.
- Myelofibrosis: Elevated NAP may be seen as the body attempts to compensate for bone marrow dysfunction.
- Neutrophilia: Increased neutrophil count can lead to elevated NAP levels.
- Essential Thrombocythaemia: NAP levels may be elevated in this myeloproliferative disorder.
- Hodgkin's Disease: Elevated NAP can occur, especially in active disease states.
- Aplastic Anaemia: NAP levels may be elevated due to compensatory mechanisms.
Causes of Low NAP Levels
- Chronic Myeloid Leukaemia (CML): Low NAP is a characteristic finding in CML and may aid in distinguishing it from reactive leukocytosis.
- Acute Myeloid Leukaemia (AML): NAP levels are typically low due to the immature nature of the leukemic cells.
- Paroxysmal Nocturnal Haemoglobinuria (PNH): NAP levels are low due to the underlying stem cell defect affecting hematopoiesis.
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