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Ibuprofen 💊
ℹ️ About
Always check the BNF link here 📖 for full prescribing information.
- Use the lowest effective dose for the shortest duration possible ⏳.
⚙️ Mode of Action
- Non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid.
- Inhibits COX-1 and COX-2 enzymes → reduced prostaglandin synthesis → analgesic, anti-inflammatory, and antipyretic effects.
- First launched in the UK in 1969 🇬🇧.
💊 Indications & Dose
| Indication | Dose / Frequency | Route |
|---|---|---|
| Analgesia, anti-inflammatory | 200–600 mg every 8 h (max 2.4 g/day in divided doses) | PO |
| Migraine | 400–800 mg stat | PO |
⚠️ Interactions
- See BNF - interactions include anticoagulants, antiplatelets, corticosteroids, SSRIs, ACE inhibitors/diuretics (↑ risk of GI bleed, renal impairment, or reduced antihypertensive efficacy).
🔎 Cautions
- Risk of GI ulceration and bleeding with long-term NSAID use. 🩸
- Consider gastric protection (PPI or misoprostol 200 mcg QDS - but note diarrhoea risk 💩).
- Use cautiously in elderly patients and those with cardiovascular risk.
🚫 Contraindications
- Active or previous GI bleeding/ulceration.
- Renal impairment, AKI, CKD, or severe liver disease.
- Severe illness where risk of AKI is high (e.g. sepsis, dehydration).
- NSAID-exacerbated asthma.
❗ Side Effects
- GI: nausea, vomiting, diarrhoea, peptic ulcer, GI bleed.
- Renal: AKI, electrolyte disturbance.
- Respiratory: bronchospasm in NSAID-sensitive asthma.
- Skin: rash, hypersensitivity reactions.
- Cardiovascular: ↑ risk of thrombotic events (MI, stroke) with long-term/high-dose use ❤️.
📚 References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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