Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Thyrotoxicosis and Hyperthyroidism |Thyroid Storm - Thyrotoxic crisis |Graves Disease (Thyrotoxicosis) |Amiodarone and Thyroid disease |Thyroid Surgery (Thyroidectomy) |Hypothyroidism |Hashimoto's thyroiditis |DeQuervain's thyroiditis |Subacute Thyroiditis |Thyroid nodule |Congenital Hypothyroidism |Thyroid Function Tests and antibodies |Post partum thyroiditis |Sick Euthyroid Syndrome |Thyroid Exam (OSCE) |Thyroid Gland anatomy and Physiology |Thyroid Cancer
| Clinical Condition | TSH (0.2–4.0 mIU/L) | Free T3 | Free T4 (10–20 pmol/L) |
|---|---|---|---|
| 🌡️ Primary thyrotoxicosis | Undetectable | High | High |
| 🔥 T3 thyrotoxicosis | Undetectable | High | Normal |
| ⚡ Subclinical thyrotoxicosis | Low / suppressed | Normal | Normal |
| đź’Š Non-thyroidal illness (sick euthyroid), Amiodarone | Low / variable | Low or high | Low / Normal |
| đź§ Secondary hypothyroidism (pituitary) | Normal / Low | Low | Low |
| ❄️ Primary hypothyroidism | Elevated | Low | Low |
| ⚠️ Subclinical hypothyroidism | Elevated | Normal | Normal |
| Antibody | Target | Associated Conditions | Clinical Significance |
|---|---|---|---|
| 🔆 Thyroid-Stimulating Immunoglobulin (TSI) | TSH Receptor | Graves’ disease | Stimulates receptor → hyperthyroidism, diffuse goitre, ophthalmopathy. |
| 🔄 TRAb (Thyrotropin receptor antibodies) | TSH Receptor | Graves’, Hashimoto’s | May stimulate or block → hyper or hypothyroidism. |
| 🛡️ Anti-TPO (Thyroid Peroxidase antibody) | Thyroid peroxidase enzyme | Hashimoto’s, Graves’ | Marker of autoimmune thyroiditis → indicates tissue destruction. |
| ⚪ Anti-Tg (Thyroglobulin antibody) | Thyroglobulin protein | Hashimoto’s, Graves’ | Seen in chronic thyroiditis; may interfere with thyroglobulin tumour marker tests. |
| 🚫 Blocking TSH receptor antibodies | TSH Receptor | Hypothyroid Graves’, neonatal hypothyroidism | Blocks stimulation → hypothyroidism, can cross placenta. |