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Related Subjects: |Thyrotoxicosis and Hyperthyroidism |Thyroid Storm - Thyrotoxic crisis |Graves Disease (Thyrotoxicosis) |Amiodarone and Thyroid disease |Thyroid Surgery (Thyroidectomy) |Hypothyroidism |Hashimoto's thyroiditis |DeQuervain's thyroiditis |Subacute Thyroiditis |Thyroid nodule |Congenital Hypothyroidism |Thyroid Function Tests and antibodies |Post partum thyroiditis |Sick Euthyroid Syndrome |Thyroid Exam (OSCE) |Thyroid Gland anatomy and Physiology |Thyroid Cancer
| Clinical Condition | TSH (0.2โ4.0 mIU/L) | Free T3 | Free T4 (10โ20 pmol/L) |
|---|---|---|---|
| ๐ก๏ธ Primary thyrotoxicosis | Undetectable | High | High |
| ๐ฅ T3 thyrotoxicosis | Undetectable | High | Normal |
| โก Subclinical thyrotoxicosis | Low / suppressed | Normal | Normal |
| ๐ Non-thyroidal illness (sick euthyroid), Amiodarone | Low / variable | Low or high | Low / Normal |
| ๐ง Secondary hypothyroidism (pituitary) | Normal / Low | Low | Low |
| โ๏ธ Primary hypothyroidism | Elevated | Low | Low |
| โ ๏ธ Subclinical hypothyroidism | Elevated | Normal | Normal |
| Antibody | Target | Associated Conditions | Clinical Significance |
|---|---|---|---|
| ๐ Thyroid-Stimulating Immunoglobulin (TSI) | TSH Receptor | Gravesโ disease | Stimulates receptor โ hyperthyroidism, diffuse goitre, ophthalmopathy. |
| ๐ TRAb (Thyrotropin receptor antibodies) | TSH Receptor | Gravesโ, Hashimotoโs | May stimulate or block โ hyper or hypothyroidism. |
| ๐ก๏ธ Anti-TPO (Thyroid Peroxidase antibody) | Thyroid peroxidase enzyme | Hashimotoโs, Gravesโ | Marker of autoimmune thyroiditis โ indicates tissue destruction. |
| โช Anti-Tg (Thyroglobulin antibody) | Thyroglobulin protein | Hashimotoโs, Gravesโ | Seen in chronic thyroiditis; may interfere with thyroglobulin tumour marker tests. |
| ๐ซ Blocking TSH receptor antibodies | TSH Receptor | Hypothyroid Gravesโ, neonatal hypothyroidism | Blocks stimulation โ hypothyroidism, can cross placenta. |