Makindo Medical Notes"One small step for man, one large step for Makindo" |
|
|---|---|
| Download all this content in the Apps now Android App and Apple iPhone/Pad App | |
| MEDICAL DISCLAIMER: The contents are under continuing development and improvements and despite all efforts may contain errors of omission or fact. This is not to be used for the assessment, diagnosis, or management of patients. It should not be regarded as medical advice by healthcare workers or laypeople. It is for educational purposes only. Please adhere to your local protocols. Use the BNF for drug information. If you are unwell please seek urgent healthcare advice. If you do not accept this then please do not use the website. Makindo Ltd. |
Related Subjects:
|Colorectal cancer
|Colorectal polyps
|Cancer Frequency and Red flags
π Peutz-Jeghers syndrome (PJS) = rare autosomal dominant disorder
π Pigmented mucocutaneous macules + multiple hamartomatous GI polyps.
β οΈ Lifetime cancer risk up to 90% by age 60.
π Summary:
Peutz-Jeghers = π pigmentation + π± GI hamartomatous polyps + 𧬠STK11 mutation.
Think: obstruction, intussusception, bleeding, and β lifetime cancer risk.
Surveillance & genetic counselling are essential.
π About
π Aetiology
π©Ί Clinical Features
π Malignancy Risks in PJS
Organ Associated Cancer
GI tract Colorectal, gastric, small bowel, pancreatic
Reproductive (β) Ovarian (esp. sex cord tumours), cervical, endometrial
Reproductive (β) Testicular Sertoli cell tumours
Other Breast, lung
π§ͺ Investigations
βοΈ Management
β οΈ Complications