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Caplacizumab
About: Always check the BNF link here
- Check BNF or equivalent for UpToDate prescribing advice
Mode of action
- Caplacizumab is a monoclonal antibody fragment (nanobody) that binds to von Willebrand factor, thereby inhibiting platelet adhesion.
Indication/Dose
- Prophylaxis of severe persistent allergic asthma
Dose range:You must check with BNF or drug datasheet
| Name | Starting Dose | Frequency | Route |
|---|---|---|---|
| Caplacizumab | Initially 10 mg for 1 dose, given before plasma exchange, followed by (by subcutaneous injection) 10 mg once daily given after each plasma exchange during, and for 30 days after finishing, daily plasma exchange therapy, treatment may be continued after this if there is evidence of unresolved immunological disease. | After each plasma exchange | Route |
Interactions
- Increased risk of bleeding
Cautions
- Avoid if bleeding
Contraindications
- Avoid if bleeding
Side effects
- Stroke, Fatigue, fever, bleeding
References
Revisions
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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