Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Organomegaly = abnormal enlargement of internal organs. Most often involves the liver (hepatomegaly), spleen (splenomegaly), and kidneys (nephromegaly). It is a clinical sign of systemic disease rather than a diagnosis itself. Causes include infection, malignancy, vascular disease, storage disorders, and metabolic conditions.
Cause | Investigations | Management |
---|---|---|
Fatty Liver (NAFLD) 🥓 | LFTs ↑ ALT/AST, US: bright liver, biopsy if severe | Lifestyle modification (weight loss, exercise), control diabetes/lipids, monitor |
Cirrhosis 🍷 | LFTs (↑ bilirubin, ALP), US/CT (nodular), biopsy | Treat cause (alcohol abstinence, antivirals), manage ascites/varices/HE, transplant if advanced |
Hepatocellular carcinoma / Metastases 🎯 | LFTs + AFP, CT/MRI, biopsy | Resection, transplant, chemo/radiotherapy, targeted/palliative therapy |
Hepatitis (Viral/Autoimmune) 🦠 | LFTs ↑ ALT/AST, viral serology, autoimmune markers, biopsy | Antivirals (HBV/HCV), immunosuppressants, monitor for cirrhosis/HCC |
Cause | Investigations | Management |
---|---|---|
Infectious Mononucleosis (EBV) 🤒 | FBC (lymphocytosis), Monospot, EBV serology, US | Supportive (hydration, rest, analgesia), avoid contact sports (rupture risk) |
Haematological Malignancy (Leukaemia, Lymphoma) 🧬 | FBC (cytopenias), marrow/lymph node biopsy, CT/PET staging | Chemo, immunotherapy, radiotherapy, transplant, supportive transfusions |
Portal Hypertension (Cirrhosis) 🩸 | LFTs, Doppler US, endoscopy for varices | Treat liver disease, beta-blockers, variceal banding, TIPS if severe |
Infections (Malaria, Leishmaniasis) 🦟 | Blood smear (malaria), serology/PCR, FBC | Antimalarials (ACT), amphotericin B/antimonials, supportive care |
Cause | Investigations | Management |
---|---|---|
Polycystic Kidney Disease 🥚 | US/CT (multiple cysts), creatinine, genetic testing | BP control (ACEi/ARB), monitor function, dialysis/transplant if ESRD |
Hydronephrosis (Obstruction) 🚰 | US (dilated renal pelvis/ureters), CT/MRI, creatinine | Relieve obstruction (stent/nephrostomy), treat cause (stone/tumour), surgery if severe |
Renal Tumours (Wilms, RCC) 🎗️ | US/CT/MRI, renal function, biopsy/resection | Nephrectomy, chemo/radiotherapy in selected cases, targeted therapy in RCC |