Makindo Medical Notes"One small step for man, one large step for Makindo" |
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MEDICAL DISCLAIMER: The contents are under continuing development and improvements and despite all efforts may contain errors of omission or fact. This is not to be used for the assessment, diagnosis, or management of patients. It should not be regarded as medical advice by healthcare workers or laypeople. It is for educational purposes only. Please adhere to your local protocols. Use the BNF for drug information. If you are unwell please seek urgent healthcare advice. If you do not accept this then please do not use the website. Makindo Ltd. |
๐ Substance | ๐ What it shows | โ ๏ธ Why it matters | ๐ฉบ Use/Indication |
---|---|---|---|
Carboxyhaemoglobin | Hb bound to CO | Carbon monoxide poisoning | CO poisoning diagnosis/monitoring |
Digoxin | Cardiac glycoside | Narrow therapeutic index โ arrhythmias | AF, heart failure |
Ethanol | Competitive ADH substrate | Antidote in methanol/ethylene glycol poisoning | Toxic alcohol ingestion |
Iron | Essential mineral | Toxic in overdose โ shock, liver failure | Iron OD, haemochromatosis |
Lithium | Mood stabiliser | Neuro-renal toxicity if high | Bipolar disorder |
Methanol | Toxic alcohol | Blindness, metabolic acidosis | Industrial/antifreeze poisoning |
Paracetamol | Analgesic | Dose-dependent hepatotoxicity | Pain, fever |
Salicylate | Aspirin | Mixed acidโbase disorder, tinnitus | Pain, antiplatelet |
โ ๏ธ Poison | ๐ก๏ธ Antidote |
---|---|
Paracetamol | N-acetylcysteine |
Opioids | Naloxone |
Benzodiazepines | Flumazenil |
Digoxin | Digoxin Fab fragments |
Iron/Aluminium | Deferoxamine |
Beta-blockers | Atropine, glucagon |
CCBs | Atropine, calcium gluconate, high-dose insulin |
Organophosphates | Atropine + pralidoxime |
Cyanide | Hydroxocobalamin, sodium thiosulfate |
Methanol / Ethylene glycol | Fomepizole or ethanol |
Warfarin | Vitamin K1 (phytomenadione) |
๐ก Exam Pearl: Always think ABCDE first, then drug-specific antidotes. A negative paracetamol level does not rule out staggered ingestion โ always treat if uncertain.