Iodine Physiology

Related Subjects: |Heme |Globins |Iodine

🧂 Introduction: Iodine is an essential trace element 🧬 required for the production of thyroid hormones (T₃ and T₄), which regulate metabolism, growth, and development throughout life. Because the body cannot make iodine, it must come from diet. Adequate iodine keeps the thyroid healthy 🦋, supports brain development 🧠, and maintains normal metabolic balance ⚖️ in every stage of life.

🌊 Sources of Iodine

🥗 Dietary Sources

Iodine content in food depends on the iodine in the soil, water, and fertilizers used — and varies by geography 🌍.

• 🐚 Marine Sources (Richest)
  • Seaweed & Marine Algae: Kelp, nori, wakame, kombu — extremely rich (can contain several thousand µg per serving).
  • Fish & Shellfish: Cod, tuna, salmon, shrimp, lobster — typically 50–150 µg per portion.
  • Sea Salt: Naturally low and inconsistent compared with iodized salt.
• 🥛 Dairy & Eggs
  • Milk, yogurt, and cheese contain 50–90 µg per serving (from iodine-enriched feed and sanitizers).
  • Eggs supply ~25 µg each, mostly in the yolk.
• 🌾 Plant Foods
  • Beans, potatoes, and grains provide modest amounts depending on soil iodine.
  • Plant foods alone rarely meet requirements unless grown in iodine-rich regions.
• 🧂 Fortified Foods
  • Iodized Salt: The most reliable source — about 45–75 µg per gram. Global salt iodization has prevented millions of cases of goiter and cretinism.
  • Some breads and cereals are also fortified in national programs.

📏 Recommended Daily Intake

• 👶 Infants 0–12 m — 110–130 µg/day
• 🧒 Children 1–8 y — 90 µg/day
• 👦 👧 9–13 y — 120 µg/day
• 🧑 Adults 14 + — 150 µg/day
• 🤰 Pregnancy — 220 µg/day
• 🤱 Lactation — 290 µg/day

⚙️ Absorption & Transport

• Iodine is ingested mainly as iodide (I⁻) or iodate (IO₃⁻); iodate is reduced to iodide before absorption.
• Absorption occurs rapidly in the stomach and small intestine — 90–95% efficiency within 1 hour ⏱️.
• Circulates in plasma as free iodide (~0.1–0.5 µg/dL), shared between thyroid uptake and renal excretion 🚽.

🦋 Thyroid Uptake & Storage

• The thyroid traps iodide via the sodium-iodide symporter (NIS) on follicular cells — concentrating it 20–50× plasma levels.
• Pendrin moves iodide into the follicular lumen for hormone synthesis.
• About 70–80% of total body iodine (15–20 mg) is stored in the thyroid; the rest in salivary glands, stomach, and mammary tissue.
• Stores can sustain hormone production for weeks during low intake.

🔬 Iodine in Thyroid Hormone Synthesis

• 🧪 Step 1 — Oxidation: Iodide → iodine by thyroid peroxidase (TPO) + H₂O₂.
• ⚗️ Step 2 — Iodination: Iodine attaches to tyrosine residues in thyroglobulin forming MIT & DIT.
• 🔗 Step 3 — Coupling: Two DIT → T₄; MIT + DIT → T₃ ✨.
• 📦 Step 4 — Release: TSH stimulates uptake of colloid, lysosomal cleavage, and release of free T₃/T₄ into blood.
• ♻️ Unused MIT & DIT are deiodinated and recycled 🔁.

🧩 Peripheral Conversion

• ~80% of circulating T₃ is formed by peripheral deiodination of T₄ in liver, kidney, and muscle.
• D1 & D2 activate (T₄→T₃); D3 inactivates (T₄→rT₃). T₃ is 3–4× more potent 💥 than T₄.

⚡ Functions of Thyroid Hormones

• 🔥 Metabolism: Raises basal metabolic rate (+60–100%), increases O₂ use and heat production.
• 🍞 Carbohydrates: Boost glucose absorption and gluconeogenesis.
• 🥩 Proteins: Stimulate synthesis; excess causes catabolism.
• 💧 Lipids: Promote lipolysis and lower LDL cholesterol.
• 🧠 Growth & Development: Crucial for brain myelination, bone growth, and fetal neurodevelopment — deficiency → cretinism.
• ❤️ Cardiovascular: ↑ HR & contractility; ↓ PVR → ↑ cardiac output; sensitises β-receptors to catecholamines.
• 🌡️ Thermoregulation: Stimulates brown-fat thermogenesis and maintains body temperature.
• 💩 GI System: Increases gut motility (→ diarrhoea if ↑ ; constipation if ↓ ).
• 🫁 Respiration: Increases ventilatory drive to match metabolic demand.

🧠 Regulation of Thyroid Function

• TRH (Hypothalamus) → stimulates TSH (Pituitary) → stimulates Thyroid to release T₄/T₃. This is the HPT axis 🔄.
• High T₃/T₄ feed back to inhibit TRH & TSH (negative feedback loop).
• Excess iodide temporarily blocks TPO (Wolff–Chaikoff effect) ⚠️ — protective mechanism against thyrotoxicosis.

🏥 Clinical Relevance

⚠️ Iodine Deficiency

• ⬇ Iodine → ⬇ T₄ → ↑ TSH → thyroid enlargement (goiter).
• Severe deficiency in pregnancy → fetal brain damage and cretinism 🧠❌.
• ~2 billion people worldwide remain at risk 🌍.
• 💊 Prevention: iodized salt, supplements for pregnancy, iodine fortified foods.

🐢 Hypothyroidism

• Symptoms → fatigue, cold intolerance, weight gain, bradycardia, dry skin, constipation, low mood.
• Common causes: Hashimoto’s thyroiditis (autoimmune), iodine deficiency, thyroid surgery or radioiodine therapy.
• 🧪 Labs: High TSH + low T₄.
• 💊 Treatment: Lifelong levothyroxine replacement + monitor TSH.

🚀 Hyperthyroidism

• Symptoms → weight loss, heat intolerance, anxiety, palpitations, tremor, diarrhoea, insomnia.
• Causes: Graves’ disease (autoimmune TSH-receptor stimulation), toxic nodules, thyroiditis.
• 🧪 Labs: Low TSH + high T₄/T₃.
• 💊 Treatment: Antithyroid drugs (methimazole/PTU), radioiodine therapy, or surgery ± β-blockers for symptom control.

🧬 Thyroid Nodules & Cancer

• Common (>50% population); 95% benign.
• Malignant types 📊 → Papillary (80%), Follicular (10–15%), Medullary (3–5%), Anaplastic (<2%).
• Investigate with ultrasound + fine-needle aspiration biopsy (FNA).
• Treatment → Surgery ± Radioiodine ± TSH suppression with high-dose T₄.

👩‍🍼 Special Populations

• 🤰 Pregnancy → iodine needs ↑ 50%; maternal hypothyroidism can impair fetal neurodevelopment.
• 👶 Infants → newborn screening for congenital hypothyroidism prevents mental impairment.
• 👵 Elderly → thyroid disease often presents atypically (e.g. “apathetic thyrotoxicosis”).

💥 Iodine Excess & Toxicity

• Usually from supplements or contrast agents.
• May cause temporary hypothyroidism (Wolff–Chaikoff) or hyperthyroidism (Jod–Basedow phenomenon).
• Safe upper limit ≈ 1100 µg/day for adults.

🌍 Public Health & Prevention

• 🧂 Universal Salt Iodization = most cost-effective strategy (20–40 mg/kg salt).
• Over 120 countries implemented → huge drop in goiter and cretinism rates 🎉.
• 📈 Monitoring via median urinary iodine (100–199 µg/L adults; 150–249 µg/L pregnant women).

🩵 Summary

In summary: Iodine is tiny but mighty 🧠🔥 — without it, the thyroid cannot make the hormones that govern metabolism, growth, and neural development. From seaweed to salt and from TSH to thyroxine, its journey is a masterclass in endocrine precision. Ensuring adequate iodine intake is one of public health’s greatest success stories — and still a priority for global well-being 🌍❤️.