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Cyclizine
Generally avoid in Nausea related to Cardiac patients particularly CCF/ACS.
About: Always check the BNF link here
- An effective and safe medicine needed in a health system
Mode of action
- Piperazine derivative with histamine H1-receptor antagonist activity
- Antimuscarinic action. N-demethylated to inactive norcyclizine
Indications/Dose
- Nausea, Vomiting, Vertigo, Motion sickness, Labyrinthine disorders
- Antiemetic: Adult Cyclizine 50 mg TDS PO/IM/IV or PRN up to 3 times a day, for motion sickness, take 1-2 hours before departure.
- Palliative care: Cyclizine 150 mg/24 hrs SC infusion
Dose range:You must check with BNF or drug datasheet
| Name | Dose | Frequency | Route |
|---|---|---|---|
| Cyclizine | 50 mg | 8-hourly PRN | PO/IV/IM/SC. |
| Cyclizine | 150 mg over 24 hrs | Continuous Syringe driver | For palliation often with opiates |
Interactions
- See BNF
Cautions
- Avoid in those with cardiac disease
- Glaucoma, Prostatism, Pregnancy
- IV dose can cause transient paralysis
- Elderly patients are more susceptible to side-effects
Contraindications
- Avoid in those with cardiac disease
- Avoid in Acute porphyrias
Side effects
- Sedation, Blurred vision, Drowsiness, Anaphylaxis, Angioedema
- Angle-closure glaucoma; arrhythmias
- Paradoxical stimulation (especially with high doses in the elderly)
References
Revisions
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