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Related Subjects: | Chronic Liver Disease | Liver Function Tests | Drug-induced Liver Injury | Liver Biopsy
Drug-induced liver injury (DILI) is a variable condition with manifestations ranging from mild enzyme elevations to acute liver failure. The onset and severity of liver damage from medications can vary, with some drugs causing transient changes in liver tests that do not require discontinuation, while others may lead to severe damage or chronic liver disease.
Side Effect | Associated Drugs | Typical Onset |
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Cholestasis | Chlorpromazine, high-dose oral contraceptive pills. | Often within the first month of treatment. |
Mixed Hepatic/Cholestatic Injury | NSAIDs, Co-Amoxiclav, Statins. | Can occur at any time during treatment. |
Acute Hepatitis | Isoniazid, Rifampicin, Paracetamol (overdose), Methyldopa, Halothane. | Varies, often within weeks to months. |
Non-Alcoholic Steatohepatitis (NASH) | Amiodarone, Tamoxifen, Tetracyclines, Sodium Valproate. | Several months to years with long-term therapy. |
Venous Obstruction (Veno-Occlusive Disease) | Busulfan, Azathioprine. | Weeks to months after treatment initiation. |
Hepatic Fibrosis | Methotrexate (with long-term use). | Years; cumulative dose-related. |
It's crucial for healthcare providers to balance the therapeutic benefits of drugs with their potential hepatotoxic effects, ensuring regular monitoring and prompt management of any signs of liver damage.