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Noradrenaline (Norepinephrine) ๐
Related Subjects: Atropine |Acute Anaphylaxis |Basic Life Support |Advanced Life Support |Adrenaline (Epinephrine) |Acute Hypotension |Cardiogenic shock |Distributive Shock |Hypovolaemic or Haemorrhagic Shock |Obstructive Shock |Septic Shock and Sepsis |Shock (General Assessment) |Toxic Shock Syndrome
๐ Noradrenaline (Norepinephrine) is used mainly in the intensive care unit (ICU) and operating theatre setting to counter acute hypotension. It is a powerful vasopressor requiring close monitoring.
โน๏ธ About
Always check the BNF link here ๐ for up-to-date details.
โ๏ธ Mode of Action
- Potent ฮฑ-adrenergic agonist โ vasoconstriction and increased systemic vascular resistance.
- Maintains perfusion to vital organs (renal, mesenteric, cerebral) at low-to-moderate doses.
๐ Indications & Dose
- Shock with low systemic vascular resistance (e.g. septic shock, distributive shock).
- Typical dose: 0.16โ0.33 ml/min (40 mcg base/ml) via central venous line; titrate to response.
- Note: 1 mg Noradrenaline base = 2 mg Noradrenaline acid tartrate.
โ ๏ธ Interactions
- See BNF for full list (risk of arrhythmias with other sympathomimetics, etc.).
๐ Cautions
- Requires continuous arterial BP monitoring.
- Extravasation can cause severe local tissue necrosis.
๐ซ Contraindications
- See BNF (e.g. uncorrected hypovolaemia should be addressed before use).
โ Side Effects
- Arrhythmias ๐
- Peripheral and mesenteric ischaemia ๐ฉธ
- Hypertension if overdosed ๐
๐ References
- BNF โ Noradrenaline/Norepinephrine monograph
๐ Revisions
- Updated: [insert date]
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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