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Nefopam 💊
⚠️ Key Safety Points: Nefopam is a non-opioid centrally acting analgesic. Avoid in patients with epilepsy or acute coronary syndromes. Notable side effect: hallucinations.
📖 About
Always refer to the British National Formulary (BNF) for the most up-to-date information on nefopam. Check the BNF link here.
⚙️ Mode of Action
- Centrally acting non-opioid analgesic.
- Inhibits reuptake of serotonin, norepinephrine, and dopamine → enhances descending inhibitory pain pathways.
💊 Indications & Dose
- Moderate pain (alternative when opioids unsuitable):
- Initial: 30–60 mg TDS.
- Elderly: Start with 30 mg TDS to reduce risk of side effects.
- Maintenance: 30–90 mg TDS.
🔗 Interactions & Cautions
- Enhanced sedation with alcohol, opioids, sedatives, or hypnotics.
- Caution in patients with history of urinary retention or angle-closure glaucoma.
- Can cause tachycardia → caution in cardiovascular disease.
🚫 Contraindications
- Convulsive disorders (e.g. epilepsy).
- Acute coronary syndromes (risk of tachycardia/arrhythmias).
❗ Side Effects
- Common: Dry mouth, dizziness, nausea, urinary retention.
- Less common: Blurred vision, confusion, drowsiness, headache, hallucinations.
- Other: Insomnia, sweating, tachycardia, vomiting.
📚 References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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