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Solifenacin 💊
📖 About
Always check the BNF link here for the latest dosing and safety information.
⚙️ Mode of Action
- Solifenacin is a selective muscarinic receptor antagonist.
- Acts mainly on the bladder detrusor muscle → ↓ involuntary contractions, ↑ bladder capacity, ↓ urgency/frequency.
💊 Indications / Dose
- 💧 Overactive bladder (frequency, urgency, incontinence): 5 mg once daily; may ↑ to 10 mg once daily if tolerated.
🔄 Interactions
- Metabolised by CYP3A4 → caution with potent inhibitors (e.g. ketoconazole, clarithromycin, ritonavir).
- ⚠️ Concomitant use with other antimuscarinics → additive side effects (dry mouth, constipation, urinary retention).
⚠️ Cautions
- 📈 QT prolongation: avoid in patients with known QT prolongation or on other QT-prolonging drugs.
- 🧪 Dose reduction required in significant renal or hepatic impairment.
- 👵 Elderly: ↑ susceptibility to CNS effects (confusion, drowsiness).
⛔ Contraindications
- 💧 Urinary retention.
- 🍽️ Severe GI disease (toxic megacolon, severe UC, GI obstruction).
- 💪 Myasthenia gravis.
- 👁️ Uncontrolled narrow-angle glaucoma.
- Always confirm via BNF.
🤒 Side Effects
- Common: 👄 Dry mouth, 🚽 Constipation, 👓 Blurred vision, 🤢 Dyspepsia/nausea.
- Others: Acid reflux, peripheral oedema, urinary retention.
- CNS (esp. elderly): Drowsiness, dizziness, confusion.
📚 References
- BNF: Solifenacin
- Katzung BG. Basic & Clinical Pharmacology, 15th Ed.
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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