Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Ferritin |CEA |ESR |CRP |ALP |LDH |HbA1c |Alpha Fetoprotein |Anti-Hu ab |Biochemical Lab values
| Acute Phase Reactant | Main Role | Clinical Notes |
|---|---|---|
| π§ͺ C-reactive protein (CRP) | Produced by liver in response to IL-6. Marker of inflammation & tissue injury. | Rises rapidly (within 6β8h); useful for infection monitoring. Faster than ESR. |
| π©Έ Fibrinogen | Clotting factor β converted to fibrin. | Elevated fibrinogen prolongs ESR; risk marker for CV disease. |
| π Serum amyloid A (SAA) | Acute inflammation protein, lipid transport, immune modulation. | Massive rise in acute infection; prolonged elevation β amyloidosis. |
| π§² Ferritin | Iron storage protein; sequesters iron from pathogens. | Also rises in HLH, COVID, Stillβs disease (hyperferritinaemia). |
| π‘οΈ Haptoglobin | Binds free Hb β prevents oxidative damage. | β in inflammation; β in haemolysis (consumed). |
| 𧬠Alpha-1 antitrypsin | Protease inhibitor β protects tissues from neutrophil elastase. | Deficiency β emphysema & liver disease; rises with inflammation. |
| β‘ Ceruloplasmin | Copper-binding protein, antioxidant & iron metabolism. | Rises with inflammation; β in Wilsonβs disease. |
| β¬οΈ Negative Acute Phase Reactants (fall during inflammation) | ||
| π§ Albumin | Maintains oncotic pressure; carrier protein. | Falls in inflammation, sepsis, malnutrition; prognostic marker. |
| π Transferrin | Iron transport protein. | Falls during inflammation β helps restrict iron to pathogens. |
| π Transthyretin (Prealbumin) | Transports thyroxine & retinol-binding protein. | Falls in acute inflammation and malnutrition; short half-life β good nutritional marker. |