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Lansoprazole
ℹ️ About
Always check the BNF link here 📖 for the most up-to-date guidance.
- Oral dispersible “fast-tab” format is useful for patients with swallowing difficulty or feeding tubes.
⚙️ Mode of Action
- Proton Pump Inhibitor (PPI) → irreversibly inhibits the H⁺/K⁺ ATPase in gastric parietal cells, suppressing gastric acid secretion.
💊 Indications & Dose
- Peptic ulcer disease / GORD / oesophagitis: 30 mg once or twice daily orally (PO) or sublingual (SL) for ≥4 weeks.
- Zollinger–Ellison syndrome: 60–120 mg/day in divided doses, titrated to acid suppression.
- Oro-dispersible tablets: 15 mg or 30 mg once daily, dissolve on the tongue if appropriate.
- Can be given via large-bore enteral tube (flush well). ❌ Avoid fine-bore tubes (risk of blockage).
⚠️ Interactions
- PPIs can reduce the antiplatelet effect of clopidogrel (particularly omeprazole, less so lansoprazole). ⚠️
- May increase risk of phenytoin toxicity and alter absorption of other pH-dependent drugs.
- Occasional CNS effects reported (e.g. agitation, dizziness, impotence).
🔎 Cautions
- See BNF — use with care in severe liver disease, osteoporosis risk, and in patients on long-term therapy (risk of hypomagnesaemia, fractures, C. difficile infection).
🚫 Contraindications
- See BNF — hypersensitivity to lansoprazole, other substituted benzimidazoles, or excipients.
❗ Side Effects
- Gastrointestinal: abdominal pain, constipation, diarrhoea, nausea, vomiting.
- Neurological: headache, dizziness, fatigue.
- Rare: hypomagnesaemia, interstitial nephritis, risk of rebound acid hypersecretion on withdrawal.
📚 References
📝 Revisions
- Updated: [insert date]
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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