Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects:Multiple System Atrophy (MSA) |Parkinson Plus syndromes |Parkinsonism |Idiopathic Parkinson disease |Progressive Supranuclear Palsy |Drug Induced Parkinson disease
| Syndrome | 🔑 Key Features | 🕵️ Diagnostic Clues | 💊 Management |
|---|---|---|---|
| 👀 Progressive Supranuclear Palsy (PSP) | Vertical gaze palsy (↓ gaze early), early backward falls, axial > limb rigidity, frontal lobe dysfunction, early dysarthria & dysphagia. | MRI “Hummingbird sign”; vertical gaze palsy is hallmark. | Poor levodopa response; physio/OT for balance, speech & swallow therapy, supportive MDT care. |
| 🫀 Multiple System Atrophy (MSA) | Early autonomic failure (orthostatic hypotension, incontinence), symmetrical parkinsonism, cerebellar ataxia, dysarthria/dysphagia, pyramidal signs. | MRI “Hot cross bun sign”; autonomic dysfunction is key clue. | Poor levodopa response; midodrine/fludrocortisone for OH, bladder care (catheterisation), physio & supportive rehab. |
| ✋ Corticobasal Degeneration (CBD) | Asymmetric parkinsonism, alien limb phenomenon, cortical sensory loss, dystonia, apraxia, cognitive decline. | Markedly asymmetric limb involvement; poor levodopa response. | Levodopa usually ineffective; physio/OT for limb control, speech therapy, supportive MDT input. |
| 🌙 Lewy Body Dementia (LBD) | Early dementia (attention, visuospatial, executive), recurrent visual hallucinations, fluctuating cognition, parkinsonism, REM sleep behaviour disorder. | Dementia develops within 1 yr of parkinsonism; levodopa may worsen hallucinations. | AChE inhibitors (rivastigmine); avoid antipsychotics ⚠️ (esp. haloperidol); cautious levodopa; melatonin/clonazepam for sleep. |