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Dosing Gentamicin
📋 Quick Guide – Gentamicin Once Daily Dosing
| 💉 Gentamicin (OD dosing protocol) | |
|---|---|
| 1 | ⚖️ Determine weight – Use Ideal Body Weight (IBW) if BMI >30 (gentamicin does not distribute into adipose). – Treatment course should not exceed 7 days without microbiology advice. |
| 2 |
🧪 Estimate Creatinine Clearance (CrCl)
(140 – age) × weight (kg) × 1.23 (men) (140 – age) × weight (kg) × 1.04 (women)⚠️ Use IBW if obese. |
| 3 |
💊 Dosing (round down to nearest 40 mg):
|
| 4 |
🧬 Monitor trough level (24 h after 1st dose):
|
| 5 | ⚠️ Do not prescribe in advance: – Never write up “48-hourly gentamicin” → risk of being given 24-hourly in error. – Prescribe on a daily review basis only. |
| 6 | 💧 Administration: Infuse in 100 mL 0.9% sodium chloride over 30 minutes. |
💡 Clinical Pearls: – Gentamicin is highly nephrotoxic & ototoxic → monitor renal function closely. – Always document indication & planned duration. – In sepsis, ensure first dose is given immediately (don’t wait for levels).
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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