Makindo Medical Notes

📖 Introduction

Urinary incontinence = involuntary loss of urine sufficient to cause social or hygiene problems. Common in older adults, particularly women, and can severely impact quality of life (embarrassment, social withdrawal, ↓ physical activity).

💊 Always review medications – many drugs (e.g. diuretics, opioids, alpha-blockers) can worsen symptoms.

🔎 Types of Urinary Incontinence

• 💨 Stress Incontinence: Leakage with ↑ intra-abdominal pressure (cough, sneeze, exercise).
  • Causes: pelvic floor weakness, childbirth trauma, menopause, obesity, prostate surgery.
  • Management: pelvic floor exercises, weight loss, pessaries, mid-urethral sling surgery, duloxetine.
• ⚡ Urge Incontinence: Sudden strong urge + leakage; often due to overactive bladder.
  • Causes: detrusor overactivity, stroke, Parkinson’s, MS, bladder irritants (caffeine, alcohol), UTI.
  • Management: bladder training, antimuscarinics (oxybutynin, solifenacin), β3 agonist (mirabegron), botulinum toxin, neuromodulation.
• 🔀 Mixed Incontinence: Combination of stress + urge.
  • Causes: pelvic floor weakness + detrusor overactivity.
  • Management: combined therapies, behavioural training, meds, surgery if needed.
• 💧 Overflow Incontinence: Continuous/intermittent dribbling due to incomplete emptying.
  • Causes: bladder outlet obstruction (BPH), diabetic neuropathy, detrusor underactivity, certain drugs.
  • Management: relieve obstruction, intermittent catheterisation, α-blockers (tamsulosin), TURP.
• 🚶 Functional Incontinence: Normal bladder but impaired ability to reach toilet.
  • Causes: arthritis, frailty, dementia, environmental barriers.
  • Management: toilet accessibility, mobility aids, carer assistance, scheduled voiding.

🧠 Teaching Pearl

Any new-onset incontinence in older adults should prompt a review for reversible causes (medications, infection, constipation, delirium). Never assume it’s “just old age.”

⚙️ Etiology & Contributing Factors

• 🧬 Physiological: Age-related pelvic floor weakness, ↓ bladder compliance.
• 🩺 Medical: Neurological disease, diabetes, UTI, prostate enlargement.
• 💊 Medications: Diuretics, opioids, CCBs, sedatives, ACE inhibitors.
• 🍷 Lifestyle: Obesity, smoking, caffeine/alcohol excess.
• 🤰 Obstetric history: Multiple pregnancies, vaginal delivery, pelvic surgery.

👩‍⚕️ Clinical Assessment

• History: onset, triggers, voiding habits, fluid intake, obstetric/gynecological history, meds, QoL impact.
• Exam: abdomen, pelvic exam (women), DRE (men), neurological exam.

🔬 Investigations

• 🧪 Urinalysis (exclude infection, haematuria, glycosuria).
• 📓 Bladder diary (3–7 days).
• 🖥️ Post-void residual (US/catheter).
• 📈 Urodynamics (if refractory or surgical planning).
• 🔎 Cystoscopy if haematuria or suspected pathology.
• 🖼️ Imaging (US/CT/MRI if anatomical cause suspected).

🩺 General Management

• 🏃 Lifestyle: weight loss, smoking cessation, ↓ caffeine/alcohol, manage constipation.
• 💊 Medication review: stop/change offending drugs.
• 🕒 Bladder training: scheduled/delayed voiding.
• 💪 Pelvic floor exercises: taught by physiotherapist or continence nurse.

💡 Condition-Specific Management

• 💨 Stress Incontinence: PFMT, duloxetine, pessaries, sling procedures, bulking agents, artificial sphincter.
• ⚡ Urge Incontinence: bladder training, antimuscarinics, mirabegron, botulinum toxin, neuromodulation.
• 💧 Overflow Incontinence: relieve obstruction, self-catheterisation, α-blockers, 5α-reductase inhibitors, TURP.
• 🚶 Functional Incontinence: toilet access, carer support, mobility aids, cognitive strategies.

💊 Medications That Worsen Incontinence

• 💦 Diuretics: urgency/frequency.
• ⬇️ Alpha-blockers: sphincter relaxation → stress incontinence (women).
• 🚫 Anticholinergics: retention → overflow.
• 💤 Opioids & sedatives: ↓ awareness & mobility.
• 😮‍💨 ACE inhibitors: cough → stress incontinence.
• ☕ Caffeine/alcohol: bladder irritants → urgency.
• ❤️ CCBs: ↓ contractility → retention.
• 🧠 Antipsychotics: impaired mobility/cognition.

🧠 Teaching Pearl

💡 If a patient presents with painless visible haematuria + incontinence, always exclude bladder cancer with urgent cystoscopy (NICE red flag).

✅ Conclusion

Urinary incontinence is multifactorial and common, but not inevitable. Careful assessment, lifestyle changes, physiotherapy, and targeted pharmacological or surgical treatments can restore continence and dramatically improve quality of life.

📚 References

• NICE Guideline NG123 (2019): Urinary Incontinence & Pelvic Organ Prolapse in Women.
• Abrams P, Andersson KE, Apostolidis A, et al. Neurourol Urodyn. 2010;29(1):213-240.
• Wein AJ, Rovner ES. Urology. 2002;60(5 Suppl 1):7-12.
• Gormley EA, Lightner DJ, Vasavada SP. J Urol. 2015;193(5):1572-1580.
• Subak LL, Richter HE, Hunskaar S. J Urol. 2009;182(6 Suppl):S2-S7.
• Lucas MG, Bedretdinova D, Berghmans LC, et al. Eur Urol. 2012;62(6):1130-1142.