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Ivabradine ๐
Related Subjects: Chronic Heart Failure | Heart Failure and Pulmonary Oedema | Loop Diuretics | Entresto Sacubitril with Valsartan | Ivabradine | Furosemide | Angiotensin Converting Enzyme Inhibitors | Cardiac Resynchronisation Therapy (CRT) Pacemaker |
โน๏ธ About
Always check the BNF link here ๐ for the most up-to-date guidance.
โ๏ธ Mode of Action
- Selective โfunny currentโ (If) channel blocker at the sinoatrial (SA) node โ slows pacemaker activity without affecting contractility or blood pressure.
๐ Indications & Dose
- Chronic stable angina in sinus rhythm, LVEF <35%, or intolerance to ฮฒ-blockers.
- Chronic heart failure (NYHA class IIโIV) in sinus rhythm with HR โฅ75 bpm, despite optimal standard therapy.
๐ Dose Range (check BNF for details)
| Name | Dose | Frequency | Route |
|---|---|---|---|
| Ivabradine | 2.5โ5 mg | BD | PO |
โ ๏ธ Interactions
- See BNF - avoid with potent CYP3A4 inhibitors, diltiazem, verapamil.
๐ Cautions
- Avoid if resting HR <60 bpm, or HR <75 bpm in heart failure.
- Contraindicated with diltiazem/verapamil (risk of profound bradycardia).
- Use caution in heart block, long QT syndrome, recent MI, or cardiogenic shock.
๐ซ Contraindications
- See BNF - sinus bradycardia, severe hypotension, sick sinus syndrome, acute decompensated heart failure, pacemaker dependence.
โ Side Effects
- Bradycardia (dose-dependent) ๐
- Atrial fibrillation โก
- Visual phenomena (โphosphenesโ - transient enhanced brightness) ๐
- Dizziness, headache, fatigue (less common).
๐ References
๐ Revisions
- Updated: [insert date]
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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