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Cefaclor
โ ๏ธ About 1โ6% of penicillin-sensitive patients will also be allergic to cephalosporins. โ Those with a history of immediate hypersensitivity to penicillin or other beta-lactams should not receive cephalosporins. โ ๏ธ Use with caution in patients with milder penicillin/ฮฒ-lactam sensitivity.
๐ About
Always check the BNF link here.
- ๐ 2nd generation cephalosporin.
- โฌ๏ธ Improved Gram-negative cover.
- โฌ๏ธ Slightly weaker Gram-positive activity compared with 1st generation cephalosporins.
โ๏ธ Action
- ๐ Inhibits peptidoglycan cross-linking โ prevents bacterial cell wall formation.
- ๐ Bactericidal action.
๐ Indications
- ๐ง Urinary tract infections (UTI).
- ๐ซ Chest infections.
- ๐ ENT infections.
- ๐ฉน Skin and soft tissue infections.
- ๐ Dose: 250โ500 mg every 8 hours (PO). Max: 4 g/day.
๐ Dose Range (check BNF / datasheet)
| Name | Dose | Frequency | Route |
|---|---|---|---|
| Cefaclor | 250โ500 mg | TDS | PO (max 4 g/day) |
๐ Interactions
- โ ๏ธ May increase warfarin effect โ monitor INR more closely.
โ ๏ธ Cautions
- ๐ซ Allergy to penicillin or cephalosporins.
- ๐ง Renal impairment (dose adjustment may be needed).
- ๐งช May cause false-positive urine glucose (dipstick).
- ๐งช May cause false-positive Coombsโ test.
โ Contraindications
- Severe hypersensitivity reactions to cephalosporins or penicillin.
๐ฅ Side Effects
- ๐คข GI: diarrhoea, nausea, vomiting, antibiotic-associated colitis.
- ๐ก๏ธ Hypersensitivity: rash, urticaria, StevensโJohnson syndrome, TEN.
- ๐งช Hepatic: hepatitis, cholestatic jaundice.
- ๐ฉธ Haematological: โ WCC, thrombocytopenia, granulocytopenia, aplastic anaemia.
- ๐ง Renal: interstitial nephritis.
- ๐ง Neurological: headache, delirium (rare).
๐ References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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