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Related Subjects: |Ferritin |CEA |ESR |CRP |ALP |LDH |HbA1c |Alpha Fetoprotein |Neutrophil Alkaline Phosphatase |Anti-Hu ab |Anti-Yo ab |Anti-SCL70 ab |Prolactin |Liver Function Tests |Biochemical Lab values
Anti-Hu antibody syndrome is a paraneoplastic neurological disorder strongly linked with small cell lung cancer (SCLC). It occurs when the immune system produces anti-Hu antibodies that cross-react with neuron-specific RNA-binding proteins โ leading to widespread neuronal injury. โ ๏ธ It belongs to the spectrum of paraneoplastic syndromes, where immune responses to cancer damage the nervous system rather than the tumour itself.
Symptoms depend on the nervous system regions affected:
Diagnosis relies on both antibody testing and exclusion of other causes:
Therapy is often difficult and response is limited:
Overall prognosis is poor. โณ Neurological deficits are usually permanent and progressive. ๐ Early cancer treatment may prolong survival but reversal of neurological symptoms is rare.