Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Idiopathic Pulmonary Fibrosis |Diffuse Parenchymal Lung disease |Asbestos Related Lung disease |Sarcoidosis |Coal Worker's Pneumoconiosis |Silicosis |Farmer's Lung |Cryptogenic Organising Pneumonia (COP-BOOP) |Extrinsic Allergic alveolitis (Hypersensitivity) |Byssinosis |Pneumoconiosis |Cor Pulmonale
| Feature | Simple CWP | Progressive Massive Fibrosis (PMF) |
|---|---|---|
| Pathology | Accumulation of coal dust in macrophages → small fibrotic nodules | Coalescence of nodules into large fibrotic masses (>1 cm) |
| Symptoms | Often asymptomatic, may have mild cough/dyspnoea | Severe exertional dyspnoea, chronic cough, weight loss, fatigue |
| Chest X-ray / HRCT | Multiple small rounded opacities (≤1 cm), upper lobe predominance | Large confluent fibrotic masses, distortion of lung architecture, emphysema |
| Pulmonary function | May be normal or show mild obstructive/restrictive pattern | Marked restrictive defect, reduced DLCO, progressive hypoxaemia |
| Complications | Usually minimal; can progress slowly even after exposure stops | Pulmonary hypertension, cor pulmonale, increased TB risk |
| Prognosis | Often benign course if exposure ceases | Poor prognosis, progressive respiratory disability |
| Management | Dust avoidance, smoking cessation, surveillance | Supportive care: LTOT, vaccination, pulmonary rehab, palliative approach in advanced cases |