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Amlodipine 💊
🦵 The commonest problem with this agent is ankle oedema, which may necessitate changing therapy, as oedema responds poorly to leg elevation or diuretics.
💊 About: Always check the BNF link here
- Acts mainly peripherally on vascular smooth muscle, less on the heart.
⚙️ Mechanism
- 🔹 Dihydropyridine class of calcium channel blocker (CCB).
- 🩸 Vasodilator effect on vascular smooth muscle.
- 💓 Claimed to have no significant negative inotropic effect.
🎯 Indications / Dose
- 💊 Hypertension, Angina, Vasospasm: 5–10 mg PO once daily (ON).
🔄 Interactions
- ⚠️ Additive effect with other antihypertensives (risk of hypotension).
- 💊 With statins: reduce simvastatin from 40 mg → 20 mg due to interaction (use atorvastatin if concerned).
⛔ Contraindications
- 📉 Hypotension.
- 🫀 Significant aortic stenosis.
- 🧬 Acute porphyria.
⚠️ Side Effects
- 💩 Constipation, fatigue.
- ❤️ Reflex tachycardia.
- 😳 Facial flushing, headache.
- 🦵 Ankle oedema (common), leg ulcers (rare).
📚 References
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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