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Imipenem (Primaxin) with Cilastin
📖 About
Always check the BNF link here.
- 💊 Imipenem is always co-administered with cilastatin.
- 🛡️ Cilastatin prevents renal degradation of imipenem, prolonging its activity.
⚙️ Action
- 🔒 Cilastatin blocks renal dehydropeptidase I, stopping imipenem inactivation.
- 🦠 Imipenem acts as the broad-spectrum bactericidal antibiotic.
🌍 Activity
- ✅ Gram-positive organisms.
- ✅ Gram-negative organisms.
- ✅ Anaerobes.
💉 Indications & Dosing – Imipenem (Primaxin) with Cilastin (verify with BNF/datasheet)
| Indication | Details |
|---|---|
| 🏥 Severe Infections |
Imipenem + Cilastin (Primaxin)
• Dose: 1–2 g daily • Route: IV infusion • Frequency: Divided into 3–4 doses • Maximum: 4 g/day |
🔄 Interactions
- 📌 See BNF for full details.
⚠️ Cautions
- 🧠 May lower seizure threshold – consider meropenem in patients with epilepsy.
- 💧 Dose adjustment required in renal impairment.
⛔ Contraindications
- 📌 Refer to BNF for full contraindications.
💥 Side Effects
- 🧠 Neurotoxicity, including seizures.
- 🤢 Gastrointestinal: nausea, vomiting, diarrhoea, antibiotic-associated colitis.
- 🌡️ Hypersensitivity: rash, urticaria, Stevens-Johnson syndrome, toxic epidermal necrolysis.
- 🧪 Haematological: positive Coombs test.
- 🩸 Hepatitis, thrombophlebitis at infusion site.
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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