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Anagrelide 💊
⚠️ For expert haematology use only Always verify dosing and monitoring via the BNF entry for Anagrelide.
📘 About
- Selective platelet-lowering agent used under specialist supervision.
- Refer to the BNF or institutional guidelines for up-to-date prescribing advice.
⚙️ Mode of Action
- Exact mechanism remains incompletely understood.
- Inhibits cyclic AMP phosphodiesterase type III (PDE-III) → reduces megakaryocyte maturation and platelet production.
💊 Indications & Dose
| Name | Typical Dose | Frequency | Route |
|---|---|---|---|
| Anagrelide (for Essential Thrombocythaemia or CML-associated thrombocytosis) | Start at 500 micrograms BD. Titrate gradually to usual dose 1–3 mg/day in divided doses.
Max per dose 2.5 mg; max daily 10 mg. |
BD–TDS | Oral |
🔗 Interactions
- Avoid concurrent use with other PDE-III inhibitors (e.g. milrinone, cilostazol, enoximone).
- Use caution with anticoagulants or antiplatelet agents (↑ bleeding risk).
⚠️ Cautions
- Monitor FBC, U&E, and LFTs regularly during treatment.
- Assess QTc interval; avoid if prolonged or in significant cardiac disease.
- Use with care in renal impairment or heart failure.
🚫 Contraindications
- Moderate to severe hepatic impairment.
- Pregnancy and breastfeeding.
💥 Side Effects
- Haematological: Thrombocytopenia, anaemia.
- Cardiac: Palpitations, tachycardia, arrhythmias, heart failure.
- GI: Nausea, diarrhoea, abdominal pain.
- Other: Headache, dizziness, oedema, dyspnoea, rare interstitial lung disease.
📚 References
- Anagrelide – BNF (NICE)
- MHRA Drug Safety Update; Specialist Haematology protocols.
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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