| Download the amazing global Makindo app: Android | Apple | |
|---|---|
| MEDICAL DISCLAIMER: Educational use only. Not for diagnosis or management. See below for full disclaimer. |
Indapamide 💊
Always check the BNF here for up-to-date prescribing advice.
- ✔️ Refer to the BNF or equivalent (e.g., NICE, local guidelines) for safe and current use.
⚙️ Mode of Action
- Indapamide is a thiazide-like diuretic.
- Blocks sodium reabsorption in the proximal segment of the distal convoluted tubule (DCT).
- Increases delivery of sodium to the distal nephron.
- Aldosterone-sensitive Na⁺/K⁺ pump ➝ enhanced potassium and hydrogen ion excretion.
📋 Indications & Standard Dose
- Hypertension: Indapamide 2.5 mg OD (usually in the morning).
🔄 Interactions
- Often combined with ACE inhibitors or ARBs to reduce hypokalaemia risk.
- NSAIDs may reduce antihypertensive effect.
- May increase lithium levels ➝ toxicity risk.
⚠️ Cautions
- Diabetes mellitus (may worsen glycaemic control).
- Gout (may increase uric acid, precipitate attacks).
- Nephrotic syndrome.
- Systemic lupus erythematosus (SLE).
⛔ Contraindications
- Severe renal or hepatic impairment.
- Refractory hypokalaemia or hyponatraemia.
- Known hypersensitivity to thiazide/thiazide-like diuretics.
⚡ Side Effects
- Metabolic: ⬆️ calcium, glucose, urate; ⬇️ chloride, bicarbonate, potassium, magnesium, sodium.
- Acute gout.
- Haematological: ↓ granulocytes, WCC, platelets (rare).
- Skin: Rashes, photosensitivity.
- Hepatic: Cholestatic jaundice (rare).
- Pulmonary: Pneumonitis (very rare).
📚 References
📝 Revisions
- Last updated: August 2025
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
|
|
Categories
- A Level
- About
- Acute Medicine
- Anaesthetics and Critical Care
- Anatomy
- Anatomy and Physiology
- Biochemistry
- Book
- Cardiology
- Collections
- CompSci
- Crib Sheets
- Dental
- Dermatology
- Differentials
- Drugs
- ENT
- Education
- Electrocardiogram
- Embryology
- Emergency Medicine
- Endocrinology
- Ethics
- Foundation Doctors
- GCSE
- Gastroenterology
- General Practice
- Genetics
- Geriatric Medicine
- Guidelines
- Gynaecology
- Haematology
- Hepatology
- Immunology
- Infectious Diseases
- Infographic
- Investigations
- Lists
- Mandatory Training
- Medical Students
- Microbiology
- Nephrology
- Neu
- Neurology
- Neurosurgery
- Nutrition
- OSCE
- OSCEs
- Obstetrics
- Obstetrics Gynaecology
- Oncology
- Ophthalmology
- Oral Medicine and Dentistry
- Orthopaedics
- Paediatrics
- Palliative
- Pathology
- Pharmacology
- Physiology
- Procedures
- Psychiatry
- Public Health
- Radiology
- Renal
- Respiratory
- Resuscitation
- Revision
- Rheumatology
- Statistics and Research
- Stroke
- Surgery
- Toxicology
- Trauma and Orthopaedics
- USMLE
- Urology
- Vascular Surgery