Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Metabolic acidosis |Aspirin or Salicylates toxicity |Ethylene glycol toxicity |Renal Tubular Acidosis |Lactic acidosis |Tricyclic Antidepressant Toxicity |Opiate Toxicity |Carbon monoxide Toxicity |Benzodiazepine Toxicity |Paracetamol (Acetaminophen) toxicity |Amphetamine toxicity |Beta Blocker toxicity |Calcium channel blockers toxicity |Cannabis toxicity |Cyanide toxicity |Digoxin Toxicity |Ecstasy toxicity |Organophosphate (OP) Toxicity |Toxin elimination by dialysis
๐งช Poisons Eliminated by Haemodialysis & Haemofiltration: Some poisons and drug overdoses can be life-threatening ๐จ. Extracorporeal removal methods โ haemodialysis and haemofiltration โ can clear these toxins effectively. Best suited when toxins are ๐ง water-soluble, โ๏ธ low molecular weight, ๐ฉธ low protein bound, and have a ๐ฆ small volume of distribution.
Extracorporeal toxin removal is considered when a poison is life-threatening, poorly managed by supportive care alone, and has favourable pharmacokinetics (low MW, low protein binding, small Vd, water soluble).
๐ Haemodialysis โ Classic Toxins |
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๐ฉธ Haemofiltration โ Useful Agents |
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๐ก Exam Pearl: Use the mnemonic "MELSIL" for haemodialysis toxins: Methanol, Ethylene glycol, Lithium, Salicylates, Isopropanol, Levels of valproate.