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Mirabegron ๐
Always check the BNF link here for latest guidance.
- โ Use if antimuscarinics are not effective or not tolerated
โ๏ธ Mode of Action
- Mirabegron is a ฮฒ3-adrenergic agonist โ relaxes detrusor muscle โ โ bladder capacity
๐ Indications / Dose
- Overactive bladder with urinary frequency, urgency, urge incontinence
- Mirabegron 50 mg OD (reduce to 25 mg in moderate hepatic or severe renal impairment)
๐ Interactions
- Reduce dose with strong CYP3A4/2D6 inhibitors (e.g. ketoconazole, clarithromycin)
- โก Caution with other QT-prolonging drugs
โ ๏ธ Cautions
- Risk of QT prolongation
- Use lower dose in hepatic or renal impairment
- Monitor BP (may increase)
โ Contraindications
- โ Severe uncontrolled hypertension
- โ Pregnancy
๐ค Side Effects
- โค๏ธ Tachycardia, palpitations, atrial fibrillation
- ๐ฆ UTI
- ๐ฝ๏ธ Dyspepsia
- ๐ Hypertension
- ๐ฃ Pruritus
๐ References
- BNF โ Mirabegron
- NICE CKS: Overactive bladder
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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