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Sodium Zirconium Cyclosilicate
About: Always check the BNF link here for the most up-to-date prescribing advice.
- Non-absorbed cation-exchange compound that selectively binds potassium in the GI tract.
- Onset of action: about 1 hour ⏱️ (faster than patiromer).
- Always verify prescribing advice in the BNF or drug datasheet before use.
⚙️ Mode of Action
- Acts as a selective potassium binder in the gastrointestinal tract.
- Exchanges sodium and hydrogen ions for potassium, increasing faecal potassium excretion.
📌 Indication
- Treatment of hyperkalaemia.
💉 Dosing (check BNF for confirmation)
- Acute Hyperkalaemia: 10 g PO every 8 hours for up to 72 hours.
- Maintenance/Ongoing Hyperkalaemia: 5–10 g PO once daily.
🔄 Interactions
- Can reduce absorption of other oral medicines → give other drugs ≥ 2 hours before or after SZC.
⚠️ Cautions
- Fluid overload and oedema risk (due to sodium content).
- Patients with heart failure, hypertension, or CKD — monitor closely.
🚫 Contraindications
- Severe constipation, bowel obstruction, or impaction.
- History of hypersensitivity to the drug or excipients.
❗ Side Effects
- Fluid imbalance, oedema, peripheral swelling.
- Constipation, nausea.
- Hypokalaemia if excessive dosing.
📚 References
- BNF – Sodium Zirconium Cyclosilicate
- Renal and hyperkalaemia management guidelines.
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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