Makindo Medical Notes"One small step for man, one large step for Makindo" |
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Related Subjects: |Inclusion Body Myositis |Inflammatory Myopathies |Polymyositis |Dermatomyositis
Feature | π Polymyositis | πΈ Dermatomyositis | π§ Inclusion Body Myositis |
---|---|---|---|
Sex | β β₯ β | β β₯ β | β β₯ β |
Age | Usually adults | Any age (children & adults) | > 50 years |
Onset | Acute / insidious | Acute / insidious | Slow, insidious |
Distribution of Weakness | Proximal β₯ distal | Proximal β₯ distal | Selective β finger flexors & quadriceps |
Course | Often rapid | Often rapid | Gradual, progressive |
Serum CK | ββ Very high | ββ Very high | Normal / mild β (β€12-fold) |
EMG | Myopathic Β± neurogenic | Myopathic Β± neurogenic | Myopathic Β± neurogenic |
Response to Tx | Good π | Good π | Poor π |
Skin Changes | No β | Yes β (heliotrope rash, Gottronβs papules) | No β |
Malignancy Risk | No β | Yes β (paraneoplastic association) | No β |
Biopsy | Intrafascicular CD8+ T cell infiltrates | Perifascicular atrophy + CD4+/B-cell infiltrates | Endomysial CD8+ T cells + rimmed vacuoles |