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Ovarian hyperstimulation syndrome 🚨 🩺
For education and revision only. Check current NICE/BNF, specialist guidance and local NHS policy before clinical use. Newly added V19 material has not received independent clinical sign-off.
Ovarian hyperstimulation syndrome (OHSS) follows ovarian stimulation and causes increased vascular permeability with third spacing, haemoconcentration and thrombotic risk.
Recognise
- Recent IVF/ovarian stimulation, rapidly increasing abdominal distension or pain, ascites, nausea and reduced urine output.
- Severe disease: dyspnoea, oliguria, hypotension, electrolyte disturbance, renal injury or thrombosis.
Immediate management
- Contact the fertility unit and gynaecology urgently; assess observations, fluid balance, urine output, weight, abdominal findings and VTE risk.
- Investigations and IV fluid decisions require specialist supervision; overaggressive fluid administration can worsen third spacing.
- Consider thromboprophylaxis and admission using current specialist severity criteria; exclude ectopic pregnancy, torsion and sepsis.
Clinical reasoning: The core physiology is capillary leak, so an oedematous patient may be intravascularly depleted.
Related Makindo topics
UK sources / further reading: RCOG OHSS guideline (2026)
| The content on this website is provided for educational and informational purposes only to support exam preparation (e.g., MLA, MRCP, USMLE) and learning. This is NOT medical advice, diagnosis, treatment, or professional guidance. It does not replace consultation with a qualified healthcare professional, official guidelines (e.g., NICE, GMC, BNF), or supervised clinical practice. Always verify information with current, authoritative sources. Makindo and its contributors accept no liability for any reliance on this content, including errors, omissions, or any resulting harm, loss, or consequences. By using this site, you agree to these terms. |
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